The mitochondrial impairment, oxidative stress and neurodegeneration connection: reality or just an attractive hypothesis?

abstract：:Recently, two large multigene families of putative G-protein-linked receptors that are expressed in distinct subpopulations of neurones in the vomeronasal organ have been identified. These receptors probably mediate pheromone detection. The most surprising aspects of these findings are that there are so many receptors...

journal_title：Trends in neurosciences

authors： Tirindelli R,Mucignat-Caretta C,Ryba NJ

更新日期：1998-11-01 00:00:00

abstract：:Several theories have proposed possible functions of adult neurogenesis in learning processes on a systems level, such as the avoidance of catastrophic interference and the encoding of temporal and contextual information, and in emotional behavior. Under the assumption of such functionality of new neurons, the questio...

journal_title：Trends in neurosciences

authors： Kempermann G

更新日期：2008-04-01 00:00:00

abstract：:To understand the role of a gene in adult behavior, it is necessary to control its expression in four dimensions: space and time. Two recent papers describe implementation of different but related technologies that now provide this missing element in fly behavioral research. ...

journal_title：Trends in neurosciences

authors： Leung B,Waddell S

更新日期：2004-09-01 00:00:00

abstract：:Recent results shed new light on how some nervous systems can regenerate after injury while others cannot. Until recently, it was widely believed that the main difference between systems that regenerate and those that do not lies in the normal state of their permissiveness to the regenerating axons. Thus, while nonreg...

journal_title：Trends in neurosciences

authors： Sivron T,Schwartz M

更新日期：1994-07-01 00:00:00

abstract：:How should evolution and development build the brain to be capable of flexible and generative cognition? I wish to put forth a 'power-of-two'-based wiring logic that provides the basic computational principle in organizing the microarchitecture of cell assemblies that would readily enable knowledge and adaptive behavi...

journal_title：Trends in neurosciences

authors： Tsien JZ

更新日期：2015-11-01 00:00:00

abstract：:The proportional relation between circulating vasopressin concentration and plasma osmolality is fundamental for body fluid homeostasis. Although changes in the sensitivity of this relation are associated with pathophysiological conditions, central mechanisms modulating osmoregulatory gain are unknown. Here, we review...

journal_title：Trends in neurosciences

authors： Prager-Khoutorsky M,Bourque CW

更新日期：2010-02-01 00:00:00

abstract：:Korsakoff's disease is an amnesic syndrome associated with midline diencephalic and brain stem pathology. A number of neurochemical systems course through or near the loci of brain lesions found postmortem in Korsakoff patients, which has stimulated studies to learn whether these systems are implicated in amnesia. Dat...

journal_title：Trends in neurosciences

authors： McEntee WJ,Mair RG

更新日期：1990-08-01 00:00:00

abstract：:An abundance of experimental literature has established that gonadal steroid hormones are responsible for the sexual differentiation of neural circuitry, mediating a variety of reproductive behaviors and physiological mechanisms. These same hormones regulate the expression of reproductive function in the adult and may...

journal_title：Trends in neurosciences

authors： Simerly RB

更新日期：1990-03-01 00:00:00

abstract：:Information that is congruent with existing knowledge (a schema) is usually better remembered than less congruent information. Only recently, however, has the role of schemas in memory been studied from a systems neuroscience perspective. Moreover, incongruent (novel) information is also sometimes better remembered. H...

journal_title：Trends in neurosciences

authors： van Kesteren MT,Ruiter DJ,Fernández G,Henson RN

更新日期：2012-04-01 00:00:00

abstract：:Many behavioral responses are completed too quickly for the underlying sensory processes to rely on estimation of neural firing rates over extended time windows. Theoretically, first-spike times could underlie such rapid responses, but direct evidence has been lacking. Such evidence has now been uncovered in the human...

journal_title：Trends in neurosciences

authors： VanRullen R,Guyonneau R,Thorpe SJ

更新日期：2005-01-01 00:00:00

abstract：:One of the major problems of living in a rich visual environment is deciding which particular object or location should be chosen for complete processing or attention; that is, deciding which object is most salient at any particular time. The pulvinar has enlarged substantially during evolution, although little has pr...

journal_title：Trends in neurosciences

authors： Robinson DL,Petersen SE

更新日期：1992-04-01 00:00:00

abstract：:Tsao et al. have recently used functional magnetic resonance imaging to compare processing for moving stereoscopic forms in macaque and human brains. Most humans exhibited activation in a swath of lateral occipital areas, extending into the intraparietal sulcus, with a limited version of the same pattern in monkeys. H...

journal_title：Trends in neurosciences

authors： Tyler CW

更新日期：2004-03-01 00:00:00

abstract：:The complex issue of translating the planning of arm movements into muscle forces is discussed in relation to the recent discovery of structures in the spinal cord. These structures contain circuitry that, when activated, produce precisely balanced contractions in groups of muscles. These synergistic contractions gene...

journal_title：Trends in neurosciences

authors： Bizzi E,Giszter SF,Loeb E,Mussa-Ivaldi FA,Saltiel P

更新日期：1995-10-01 00:00:00

abstract：:Imagine the decisions you might make while playing a simple game like 'matching pennies'. At each play, you and your opponent, say the mathematician John vonNeumann, each lay down a penny heads or tails up. If both pennies show the same side, vonNeumann wins, if not, you win. Before each play, you have the subjective ...

journal_title：Trends in neurosciences

authors： Glimcher PW

更新日期：2001-11-01 00:00:00

abstract：:A large body of evidence suggests that neural plasticity contributes to learning and disease. Recent studies suggest that cortical map plasticity is typically a transient phase that improves learning by increasing the pool of task-relevant responses. Here, I discuss a new perspective on neural plasticity and suggest h...

journal_title：Trends in neurosciences

authors： Kilgard MP

更新日期：2012-12-01 00:00:00

abstract：:In mature rodents, whisker-related patterns are known to be present in three levels of the brain: the brainstem trigeminal nuclei, the ventrobasal thalamus and the somatosensory cortex. These patterns have been demonstrated using neuroanatomical tracing techniques, histological and histochemical staining methods and e...

journal_title：Trends in neurosciences

authors： Waite PM,Marotte LR,Leamey CA,Mark RF

更新日期：1998-06-01 00:00:00

abstract：:The number of neuroscientists in Europe is large enough to match that of the neuroscientific community in North America. However, the degree of cohesiveness in the former is hampered by, among other things, the lack of a common language, the existence of geopolitical boundaries, and the dearth of pan-European funding ...

journal_title：Trends in neurosciences

authors： Singer W

更新日期：1994-08-01 00:00:00

abstract：:In their 1994 paper, Monyer et al. described unique functional properties and cell type-specific expression of NMDA receptor (NMDAR) GluN2 subunits, suggesting that the roles of NMDAR vary across brain regions and throughout development. This influential work not only provided insight into how molecular diversity impa...

journal_title：Trends in neurosciences

authors： Swanger SA,Traynelis SF

更新日期：2018-08-01 00:00:00

abstract：:Genetic studies have identified several of the genes associated with malformations of cortical development which might disrupt each of the main stages of cell proliferation and specification, neuronal migration and late cortical organization. The largest malformation groups, focal cortical dysplasia, heterotopia and p...

journal_title：Trends in neurosciences

authors： Guerrini R,Dobyns WB,Barkovich AJ

更新日期：2008-03-01 00:00:00

abstract：:Lyme disease is of interest to the neurologist and neuroscientist for a variety of reasons. As more arthropod hosts throughout the world are infected with the causative organism, Borrelia burgdorferi, the illness in humans is becoming more prevalent; in addition, recognition of the disease in humans and susceptible an...

journal_title：Trends in neurosciences

authors： Pachner AR

更新日期：1989-05-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTLs) with a CD8(+) phenotype have the potential to recognize and attack major histocompatibility complex (MHC) class I-expressing brain cells. Most brain cells, including neurons, can be stimulated to present peptides to CD8(+) CTLs by MHC class I molecules, and are susceptible to CTL-mediate...

journal_title：Trends in neurosciences

authors： Neumann H,Medana IM,Bauer J,Lassmann H

更新日期：2002-06-01 00:00:00

abstract：:The vertebrate neuromuscular junction (NMJ), a peripheral synapse formed between motoneuron and skeletal muscle, is characterized by a protracted postnatal period of maturation and life-long maintenance. In neuromuscular disorders such as congenital myasthenic syndromes (CMSs), disruptions of NMJ maturation and/or mai...

journal_title：Trends in neurosciences

authors： Shi L,Fu AK,Ip NY

更新日期：2012-07-01 00:00:00

abstract：:Antisocial aggression is a widespread and expensive social problem. Although aggressive behaviors and temperament are highly heritable, clinical and trait associations for the most promising candidate gene for aggression, MAOA, have been largely inconsistent. We suggest that limitations inherent to that approach might...

journal_title：Trends in neurosciences

authors： Buckholtz JW,Meyer-Lindenberg A

更新日期：2008-03-01 00:00:00

abstract：:Active feedback mechanisms in the ears of mammals amplify and tune the auditory response to sound stimuli, allowing these organisms to enjoy both exquisite sensitivity and sharp frequency selectivity. A requisite component of this feedback pathway has recently been identified. Targeted deletion of pres, the gene that ...

journal_title：Trends in neurosciences

authors： Géléoc GS,Holt JR

更新日期：2003-03-01 00:00:00

abstract：:Axonal transport is critical for neuronal homeostasis and relies on motor complexes bound to cargoes via specific adaptors. However, the mechanisms responsible for the spatiotemporal regulation of axonal transport are not completely understood. A recent study by Liao et al. contributes to filling this gap by reporting...

journal_title：Trends in neurosciences

authors： Fratta P,Birsa N,Tosolini AP,Schiavo G

更新日期：2020-01-01 00:00:00

abstract：:A general assay for evaluating functional interactions between ligands and G-protein-coupled receptors within minutes has been developed. The system uses the principles employed by animals such as reptiles, amphibians and fish to control their colors. In nature, activation of G-protein-coupled receptors expressed by s...

journal_title：Trends in neurosciences

authors： Lerner MR

更新日期：1994-04-01 00:00:00

abstract：:Previous studies have demonstrated that oligodendrocytes in the spinal cord and brainstem originate from restricted domains of ventral neuroepithelium under the influence of sonic hedgehog protein (SHH). However, the origin of oligodendrocytes in the telencephalon, the most anterior part of the CNS, has not been estab...

journal_title：Trends in neurosciences

authors： Qi Y,Stapp D,Qiu M

更新日期：2002-05-01 00:00:00

abstract：:Intensive mapping of the essential cerebellar brain circuits for Pavlovian eyeblink conditioning appeared relatively complete by 2000, but new data indicate the need for additional differentiation of cerebellar regions and mechanisms coding delay and trace conditioning. This is especially important, as trace condition...

journal_title：Trends in neurosciences

authors： Woodruff-Pak DS,Disterhoft JF

更新日期：2008-02-01 00:00:00

abstract：:How does an extracellular guidance molecule direct multiple growth cones to different positions? The answer is important for understanding the development of complex neural connections. UNC-6 is a member of the netrin family of guidance proteins. It has phylogenetically conserved domains that mediate its different gui...

journal_title：Trends in neurosciences

authors： Wadsworth WG

更新日期：2002-08-01 00:00:00

abstract：:In many neurological and psychiatric disorders, including Alzheimer's disease and schizophrenia, symptoms are present that appear to reflect an essential absence of normal movement, cognition and emotional states. These negative symptoms might reflect fundamental impairments in basic brain mechanisms that underlie goa...

journal_title：Trends in neurosciences

authors： Brown RG,Pluck G

更新日期：2000-09-01 00:00:00