Abstract:
:In many neurological and psychiatric disorders, including Alzheimer's disease and schizophrenia, symptoms are present that appear to reflect an essential absence of normal movement, cognition and emotional states. These negative symptoms might reflect fundamental impairments in basic brain mechanisms that underlie goal-directed behaviour. Knowledge of the pathology and pathophysiology of these diseases, combined with evidence from basic science, offers opportunities for understanding the neurobiological basis of goal-directed behaviour, particularly the interaction between limbic structures and striato-thalamo-cortical circuits. The study of patients with negative symptoms also provides opportunities for testing cognitive models of goal-directed behaviour, and eventually to map such models onto the neurobiology of both normal and abnormal behaviour.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Brown RG,Pluck Gdoi
10.1016/s0166-2236(00)01626-xsubject
Has Abstractpub_date
2000-09-01 00:00:00pages
412-7issue
9eissn
0166-2236issn
1878-108Xpii
S0166-2236(00)01626-Xjournal_volume
23pub_type
杂志文章,评审abstract::Serotonin is an important neuromodulator associated with a wide range of physiological effects in the central nervous system. The exact mechanisms whereby serotonin influences brain development are not well understood, although studies in invertebrate and vertebrate model organisms are beginning to unravel a regulator...
journal_title:Trends in neurosciences
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journal_title:Trends in neurosciences
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doi:10.1016/s0166-2236(02)02241-5
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abstract::Rhythmical brain activity around 5Hz can be observed in the prefrontal cortex under conditions requiring high levels of cognitive control. However, its temporal dynamics are still elusive. A recent research paper (Cooper et al. Neuroimage 2019;189:130-140) provides evidence that the temporal evolution of this frontal-...
journal_title:Trends in neurosciences
pub_type: 评论,杂志文章
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abstract::Recent results shed new light on how some nervous systems can regenerate after injury while others cannot. Until recently, it was widely believed that the main difference between systems that regenerate and those that do not lies in the normal state of their permissiveness to the regenerating axons. Thus, while nonreg...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/0166-2236(94)90056-6
更新日期:1994-07-01 00:00:00
abstract::Most neurons are generated during development and are not replaced during adulthood, even if they are lost to injury or disease. However, it is firmly established that new neurons are generated in the dentate gyrus of the hippocampus of almost all adult mammals, including humans. Nevertheless, many questions remain re...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2015.07.005
更新日期:2015-09-01 00:00:00
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journal_title:Trends in neurosciences
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更新日期:1995-07-01 00:00:00
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journal_title:Trends in neurosciences
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doi:10.1016/s0166-2236(02)02145-8
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journal_title:Trends in neurosciences
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2015.01.001
更新日期:2015-02-01 00:00:00
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/0166-2236(93)90043-l
更新日期:1993-01-01 00:00:00
abstract::Purinergic receptors, represented by several families, are arguably the most abundant receptors in living organisms and appeared early in evolution. After slow acceptance, purinergic signalling in both peripheral and central nervous systems is a rapidly expanding field. Here, we emphasize purinergic co-transmission, m...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2008.10.001
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journal_title:Trends in neurosciences
pub_type: 杂志文章
doi:10.1016/0166-2236(92)90006-t
更新日期:1992-11-01 00:00:00
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2007.05.001
更新日期:2007-07-01 00:00:00
abstract::Brain dynamic changes associated with schizophrenia are largely equivocal, with interpretation complicated by many factors, such as the presence of therapeutic agents and the complex nature of the syndrome itself. Evidence for a brain-wide change in individual network oscillations, shared by all patients, is largely e...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2017.04.003
更新日期:2017-06-01 00:00:00
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journal_title:Trends in neurosciences
pub_type: 杂志文章
doi:10.1016/s0166-2236(00)01747-1
更新日期:2001-03-01 00:00:00
abstract::Recent studies of the iconic fall migration of monarch butterflies have illuminated the mechanisms behind their southward navigation while using a time-compensated sun compass. Skylight cues, such as the sun itself and polarized light, are processed through both eyes and are probably integrated in the brain's central ...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2010.04.004
更新日期:2010-09-01 00:00:00
abstract::Huntington's disease is an inherited neurodegenerative disorder, the cause of which is unknown. Excitotoxicity, mitochondrial dysfunction and oxidative stress are all likely to contribute to the striatal cell death that occurs in this disorder. There are accumulating data indicating that under specific circumstances, ...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(00)01568-x
更新日期:2000-06-01 00:00:00
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
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abstract::In 1983 Libet et al. demonstrated that brain activity associated with a voluntary act precedes conscious experience of the intention to act by several hundred milliseconds. The implication that it is the brain, rather than 'free will', that initiates voluntary acts has been discussed ever since by philosophers and law...
journal_title:Trends in neurosciences
pub_type: 评论,杂志文章
doi:10.1016/j.tins.2018.04.009
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journal_title:Trends in neurosciences
pub_type: 杂志文章
doi:10.1016/s0166-2236(02)02161-6
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abstract::Dendrites of pyramidal neurons are complex, electrically active structures that can produce local and global Ca(2+) compartments. Recent studies indicate that dendrites of cortical GABAergic interneurons are also highly specialized, and that different subtypes vary in their morphology, in their intrinsic and synaptic ...
journal_title:Trends in neurosciences
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doi:10.1016/j.tins.2005.01.005
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abstract::The current dominant model of binaural sound localization proposes that the lateral position of a sound source is determined by the position of maximal activation within an array of binaural coincidence-detector neurons that are tuned to different interaural time differences (ITDs). The tuning of a neuron for an ITD i...
journal_title:Trends in neurosciences
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doi:10.1016/S0166-2236(03)00140-1
更新日期:2003-07-01 00:00:00
abstract::Lyme disease is of interest to the neurologist and neuroscientist for a variety of reasons. As more arthropod hosts throughout the world are infected with the causative organism, Borrelia burgdorferi, the illness in humans is becoming more prevalent; in addition, recognition of the disease in humans and susceptible an...
journal_title:Trends in neurosciences
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journal_title:Trends in neurosciences
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abstract::No therapy exists to slow down or prevent Parkinson's disease (PD), a debilitating neurodegenerative disorder. Neurotrophic factors (NTFs) emerged as promising disease-modifying agents in PD and are currently under clinical development. We argue that efforts in three research areas must converge to harness the full th...
journal_title:Trends in neurosciences
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更新日期:2011-02-01 00:00:00
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journal_title:Trends in neurosciences
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更新日期:2002-05-01 00:00:00
abstract::The 'thrifty gene hypothesis' posits that evolution preferentially selects physiological mechanisms that optimize energy storage to increase survival under alternating conditions of abundance and scarcity of food. Recent experiments suggest that endocannabinoids - a class of lipid-derived mediators that activate canna...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
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更新日期:2012-07-01 00:00:00
abstract::The molecular nature of the metabotropic GABA(B) receptor was for some time a mystery, however it was recently discovered that two related G-protein-coupled receptors have to heterodimerize to form the functional GABA(B) receptor at the cell surface. This review discusses the most recent findings in the rapidly expand...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
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更新日期:2001-05-01 00:00:00