Abstract:
:Antisocial aggression is a widespread and expensive social problem. Although aggressive behaviors and temperament are highly heritable, clinical and trait associations for the most promising candidate gene for aggression, MAOA, have been largely inconsistent. We suggest that limitations inherent to that approach might be overcome by using multimodal neuroimaging to characterize neural mechanisms of genetic risk. Herein, we detail functional, structural and connectivity findings implicating the low-expressing allele of the MAOA u-VNTR (MAOA-L) in adversely prejudicing information processing within a corticolimbic circuit composed of amygdala, rostral cingulate and medial prefrontal cortex. We propose that the MAOA-L, by causing an ontogenic excess of 5-hydroxytryptamine, labilizes critical neural circuitry for social evaluation and emotion regulation (the 'socioaffective scaffold'), thereby amplifying the effects of adverse early-life experience and creating deleterious sociocognitive biases. Our construct provides a neurobiologically consistent model for gene-environment interactions in impulsive aggression.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Buckholtz JW,Meyer-Lindenberg Adoi
10.1016/j.tins.2007.12.006subject
Has Abstractpub_date
2008-03-01 00:00:00pages
120-9issue
3eissn
0166-2236issn
1878-108Xpii
S0166-2236(08)00039-8journal_volume
31pub_type
杂志文章abstract::In the central nervous system (CNS) the function of retinoic acid, the active metabolite of vitamin A, is best understood from its action in guiding embryonic development; as development comes to completion, retinoic acid signaling declines. However, it is increasingly recognized that this signaling mechanism does not...
journal_title:Trends in neurosciences
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journal_title:Trends in neurosciences
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journal_title:Trends in neurosciences
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journal_title:Trends in neurosciences
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journal_title:Trends in neurosciences
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journal_title:Trends in neurosciences
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doi:10.1016/j.tins.2009.01.004
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journal_title:Trends in neurosciences
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doi:10.1016/j.tins.2011.08.005
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journal_title:Trends in neurosciences
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doi:10.1016/0166-2236(94)90171-6
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doi:10.1016/j.tins.2012.04.006
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pub_type: 杂志文章,评审
doi:10.1016/j.tins.2007.05.001
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doi:10.1016/j.tins.2011.07.004
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pub_type: 杂志文章,评审
doi:10.1016/j.tins.2007.02.003
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doi:10.1016/j.tins.2007.11.006
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journal_title:Trends in neurosciences
pub_type: 杂志文章
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journal_title:Trends in neurosciences
pub_type: 杂志文章
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journal_title:Trends in neurosciences
pub_type: 杂志文章
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
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journal_title:Trends in neurosciences
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