Abstract:
:Anatomical and functional studies of the prefrontal cortex (PFC) have identified multiple PFC subregions. We argue that the PFC is involved in cognitive functions exceeding the sum of specific functions attributed to its subregions. These can be revealed either by lesions of the whole PFC, or more specifically by selective disconnection of the PFC from certain types of information (for example, visual) allowing the investigation of PFC function in toto. Recent studies in macaque monkeys using the latter approach lead to a second conclusion: that the PFC, as a whole, could be fundamentally specialized for representing events that are extended in time. The representation of temporally complex events might underlie PFC involvement in general intelligence, decision-making, and executive function.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Wilson CR,Gaffan D,Browning PG,Baxter MGdoi
10.1016/j.tins.2010.08.001subject
Has Abstractpub_date
2010-12-01 00:00:00pages
533-40issue
12eissn
0166-2236issn
1878-108Xpii
S0166-2236(10)00108-6journal_volume
33pub_type
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