Abstract:
:Immunoglobulin superfamily adhesion molecules are among the most abundant proteins in vertebrate and invertebrate nervous systems. Prominent family members are the neural cell adhesion molecules NCAM and L1, which were the first to be shown to be essential not only in development but also in synaptic function and as key regulators of synapse formation, synaptic activity, plasticity, and synaptic vesicle recycling at distinct developmental and activity stages. In addition to interacting with each other, adhesion molecules interact with ion channels and cytokine and neurotransmitter receptors. Mutations in their genes are linked to neurological disorders associated with abnormal development and synaptic functioning. This review presents an overview of recent studies on these molecules and their crucial impact on neurological disorders.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Sytnyk V,Leshchyns'ka I,Schachner Mdoi
10.1016/j.tins.2017.03.003subject
Has Abstractpub_date
2017-05-01 00:00:00pages
295-308issue
5eissn
0166-2236issn
1878-108Xpii
S0166-2236(17)30032-2journal_volume
40pub_type
杂志文章,评审abstract::Recent studies of the iconic fall migration of monarch butterflies have illuminated the mechanisms behind their southward navigation while using a time-compensated sun compass. Skylight cues, such as the sun itself and polarized light, are processed through both eyes and are probably integrated in the brain's central ...
journal_title:Trends in neurosciences
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journal_title:Trends in neurosciences
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journal_title:Trends in neurosciences
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