Abstract:
:How the brain becomes lateralized is poorly understood. By contrast, much is known about molecular cues that specify the left-right axis of the body, fashioning the asymmetric morphology and positioning of the visceral organs. In zebrafish, the Nodal signaling pathway functions in visceral asymmetry and also in the embryonic brain, to bias laterality of the epithalamus. Formation of an asymmetric pineal complex differentially influences adjacent diencephalic nuclei, the left and right habenulae, which acquire distinctive molecular and cellular features. Results from the genetically tractable zebrafish system provide a promising entry point for exploring how left-right biases are established and propagated in the developing vertebrate brain.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Halpern ME,Liang JO,Gamse JTdoi
10.1016/S0166-2236(03)00129-2subject
Has Abstractpub_date
2003-06-01 00:00:00pages
308-13issue
6eissn
0166-2236issn
1878-108Xpii
S0166-2236(03)00129-2journal_volume
26pub_type
杂志文章,评审abstract::A model is proposed whereby the spread of long-term potentiation (LTP) between potentiated and neighboring neurons is initiated by a retrograde signal that is restricted to the synaptic clefts of the potentiated neurons. Next, a change, such as enhanced release of neurotransmitter, occurs in the presynaptic boutons th...
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