Abstract:
:The hippocampus is thought to automatically encode all experience, yet the vast majority of our experiences are not remembered later. Although psychological theories have postulated the existence of decay processes for declarative memory, the corresponding neurobiological mechanisms are unknown. Here we develop the hypothesis that ongoing hippocampal neurogenesis represents a decay process that continually clears memories from the hippocampus. As newborn granule cells integrate into established hippocampal circuits, they form new input and output connections over the course of several weeks. Because successful memory retrieval relies on reinvoking patterns of activity that occurred at the time of encoding (pattern completion), neurogenesis-induced remodeling of hippocampal circuits incrementally reduces the likelihood that a given retrieval cue will reinvoke a previously stored pattern.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Frankland PW,Köhler S,Josselyn SAdoi
10.1016/j.tins.2013.05.002subject
Has Abstractpub_date
2013-09-01 00:00:00pages
497-503issue
9eissn
0166-2236issn
1878-108Xpii
S0166-2236(13)00086-6journal_volume
36pub_type
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