Abstract:
:Systematic genetic screens have been powerful tools in identifying genes responsible for axon guidance in fruitflies and nematodes. This approach has now been extended to the study of axon guidance and the formation of topographic neuronal connections in the vertebrate brain. A systematic genetic screen was used to identify genes responsible for precise axon pathfinding and targeting in the retinotectal system of the zebrafish (Danio rerio). Over 30 genes were found that affect either: (1) retinal axon pathfinding to the contralateral tectal lobe; or (2) the topographic connection between the eye and the tectum. The zebrafish retinotectal mutants represent a new resource for the study of axon guidance in the vertebrate brain.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Karlstrom RO,Trowe T,Bonhoeffer Fdoi
10.1016/S0166-2236(96)40005-4subject
Has Abstractpub_date
1997-01-01 00:00:00pages
3-8issue
1eissn
0166-2236issn
1878-108Xpii
S0166-2236(96)40005-4journal_volume
20pub_type
杂志文章,评审abstract::Women experience many pain conditions more frequently when compared with men, but the biological mechanisms underlying sex differences in pain remain poorly understood. In particular, little is known about possible sex differences in peripheral nociceptors, the fundamental building blocks of pain transmission. Emergin...
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