Abstract:
:More often than not, action potentials fail to trigger neurotransmitter release. And even when neurotransmitter is released, the resulting change in synaptic conductance is highly variable. Given the energetic cost of generating and propagating action potentials, and the importance of information transmission across synapses, this seems both wasteful and inefficient. However, synaptic noise arising from variable transmission can improve, in certain restricted conditions, information transmission. Under broader conditions, it can improve information transmission per release, a quantity that is relevant given the energetic constraints on computing in the brain. Here we discuss the role, both positive and negative, synaptic noise plays in information transmission and computation in the brain.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Rusakov DA,Savtchenko LP,Latham PEdoi
10.1016/j.tins.2020.03.009subject
Has Abstractpub_date
2020-06-01 00:00:00pages
363-372issue
6eissn
0166-2236issn
1878-108Xpii
S0166-2236(20)30069-2journal_volume
43pub_type
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