Abstract:
:This review focuses on the epileptic human temporal lobe, primarily on recent findings related to changes in hippocampal GABAergic interneuron circuits that have a central role in epileptogenesis. Relying on correlations to animal studies, we provide a functional interpretation of the different changes in perisomatic inhibition (controlling output synchrony) and dendritic inhibition (controlling input plasticity), and the potential consequences of the loss of interneuron-selective interneurons. The highly heterogeneous, but specific, alterations of GABAergic interneuron circuits have important implications for the pharmacotherapy of epilepsy.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Maglóczky Z,Freund TFdoi
10.1016/j.tins.2005.04.002subject
Has Abstractpub_date
2005-06-01 00:00:00pages
334-40issue
6eissn
0166-2236issn
1878-108Xpii
S0166-2236(05)00100-1journal_volume
28pub_type
杂志文章,评审abstract::Recent years have seen a flourishing literature on detection of circulating autoantibodies against neurotransmitter receptors in patients with neuropsychiatric disorders. These studies have generated hope for a better understanding of the underlying molecular dysfunctions and for appropriate therapeutic strategies. Ho...
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