Abstract：
:Rhythmic motor activity requires coordination of different muscles or muscle groups so that they are all active with the same cycle duration and appropriate phase relationships. The neural mechanisms for such phase coupling in vertebrate locomotion are not known. Swimming in the lamprey is accomplished by the generation of a travelling wave of body curvature in which the phase coupling between segments is so controlled as to give approximately one full wavelength on the body at any swimming speed. This article reviews work that has combined mathematical analysis, biological experimentation and computer simulation to provide a conceptual framework within which intersegmental coordination can be investigated. Evidence is provided to suggest that in the lamprey, ascending coupling is dominant over descending coupling and controls the intersegmental phase lag during locomotion. The significance of long-range intersegmental coupling is also discussed.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Cohen AH,Ermentrout GB,Kiemel T,Kopell N,Sigvardt KA,Williams TLdoi
10.1016/0166-2236(92)90006-tsubject
Has Abstractpub_date
1992-11-01 00:00:00pages
434-8issue
11eissn
0166-2236issn
1878-108Xpii
0166-2236(92)90006-Tjournal_volume
15pub_type
杂志文章abstract：:Sensory dendrites fall into many different morphological and functional classes. Polymodal nociceptors are one subclass of sensory neurons, which are of particular note owing to their elaborate dendritic arbors. Complex developmental programs are required to form these arbors and there is striking conservation of morp...
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journal_title：Trends in neurosciences
pub_type： 杂志文章
doi：10.1016/j.tins.2008.01.002
更新日期：2008-04-01 00:00:00
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journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/s0166-2236(98)01283-1
更新日期：1998-12-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1016/j.tins.2007.12.004
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doi：10.1016/j.tins.2008.02.008
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pub_type： 杂志文章
doi：10.1016/j.tins.2007.12.006
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journal_title：Trends in neurosciences
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journal_title：Trends in neurosciences
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journal_title：Trends in neurosciences
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abstract：:Dendrites of pyramidal neurons are complex, electrically active structures that can produce local and global Ca(2+) compartments. Recent studies indicate that dendrites of cortical GABAergic interneurons are also highly specialized, and that different subtypes vary in their morphology, in their intrinsic and synaptic ...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2005.01.005
更新日期：2005-03-01 00:00:00
abstract：:The ability of central synapses to undergo long-term potentiation (LTP) still captures the imagination of scientists and has become one of the most fascinating and deeply studied questions in modern neuroscience. By the mid-1990s, however, the field was deeply ensnarled in trying to answer a passionately dichotomous q...
journal_title：Trends in neurosciences
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abstract：:Maladaptive responses to stress and the associated hypersecretion of glucocorticoids cause psychopathologies ranging from hyperemotional states and mood dysfunction to cognitive impairments. Research in both humans and animal models has begun to identify morphological correlates of these functional changes. These incl...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
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更新日期：2012-12-01 00:00:00
abstract：:No therapy exists to slow down or prevent Parkinson's disease (PD), a debilitating neurodegenerative disorder. Neurotrophic factors (NTFs) emerged as promising disease-modifying agents in PD and are currently under clinical development. We argue that efforts in three research areas must converge to harness the full th...
journal_title：Trends in neurosciences
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