Molecular genetic studies in the neuropsychiatric disorders.

abstract：:During prenatal brain development, ion channels are ubiquitous across several cell types, including progenitor cells and migrating neurons but their function has not been clear. In the past, ion channel dysfunction has been primarily studied in the context of postnatal, differentiated neurons that fire action potentia...

journal_title：Trends in neurosciences

authors： Smith RS,Walsh CA

更新日期：2020-02-01 00:00:00

abstract：:The nervous system contains a diverse group of cells. Specification of the correct cell fate is obviously important for the proper function of the nervous system, yet how are the fates of different neurons determined during development? Very little is known about the underlying molecular mechanisms used in the mammali...

journal_title：Trends in neurosciences

authors： Jan YN,Jan LY

更新日期：1990-12-01 00:00:00

abstract：:Recent studies of the iconic fall migration of monarch butterflies have illuminated the mechanisms behind their southward navigation while using a time-compensated sun compass. Skylight cues, such as the sun itself and polarized light, are processed through both eyes and are probably integrated in the brain's central ...

journal_title：Trends in neurosciences

authors： Reppert SM,Gegear RJ,Merlin C

更新日期：2010-09-01 00:00:00

abstract：:Glucose has long been considered the substrate for neuronal energy metabolism in the brain. Recently, an alternative explanation of energy metabolism in the active brain, the astrocyte-neuron lactate shuttle hypothesis, has received attention. It suggests that during neural activity energy needs in glia are met by ana...

journal_title：Trends in neurosciences

authors： Chih CP,Lipton P,Roberts EL Jr

更新日期：2001-10-01 00:00:00

abstract：:Priming is the process by which vesicles become available for fusion at nerve terminals and is modulated by numerous proteins and second messengers. One of the prominent members of this diverse family is tomosyn. Tomosyn has been identified as a syntaxin-binding protein; it inhibits vesicle priming, but its mode of ac...

journal_title：Trends in neurosciences

authors： Ashery U,Bielopolski N,Barak B,Yizhar O

更新日期：2009-05-01 00:00:00

abstract：:Several modes of synaptic vesicle release, retrieval and recycling have been identified. In a well-established mode of exocytosis, termed 'full-collapse fusion', vesicles empty their neurotransmitter content fully into the synaptic cleft by flattening out and becoming part of the presynaptic membrane. The fused vesicl...

journal_title：Trends in neurosciences

authors： Smith SM,Renden R,von Gersdorff H

更新日期：2008-11-01 00:00:00

abstract：:In the central nervous system (CNS) the function of retinoic acid, the active metabolite of vitamin A, is best understood from its action in guiding embryonic development; as development comes to completion, retinoic acid signaling declines. However, it is increasingly recognized that this signaling mechanism does not...

journal_title：Trends in neurosciences

authors： Shearer KD,Stoney PN,Morgan PJ,McCaffery PJ

更新日期：2012-12-01 00:00:00

abstract：:Hebbian synaptic learning requires co-activation of presynaptic and postsynaptic neurons. However, under some conditions, information regarding the postsynaptic action potential, carried by backpropagating action potentials, can be strongly degraded before it reaches the distal exhibit Hebbian long-term potentiation (...

journal_title：Trends in neurosciences

authors： Mehta MR

更新日期：2004-02-01 00:00:00

abstract：:The myelinated axon provides a model in which it is possible to examine how various types of ion channels are incorporated into a membrane to form an excitable neuronal process. The available evidence now indicates that mammalian myelinated fibers contain a repertoire of physiologically active membrane molecules inclu...

journal_title：Trends in neurosciences

authors： Black JA,Kocsis JD,Waxman SG

更新日期：1990-02-01 00:00:00

abstract：:The production by the pyridine MPTP of a parkinsonian syndrome strikingly similar to the 'idiopathic' disorder, and the paucity of evidence supporting a hereditary or infectious etiology for Parkinson's disease (PD), have stimulated a search for environmental chemicals resembling MPTP that might cause PD. In support o...

journal_title：Trends in neurosciences

authors： Tanner CM

更新日期：1989-02-01 00:00:00

abstract：:Major themes in neuroethology concern the specificity of key stimuli, neurones tuned to such stimuli, and the release of corresponding behaviour. Neurobiological data from the analysis of visuomotor functions of prey-catching and avoiding in amphibians support the view that retinal outflow in different combinations is...

journal_title：Trends in neurosciences

authors： Ewert JP

更新日期：1997-08-01 00:00:00

abstract：:Unlike most mammalian species, the prairie vole is highly affiliative, forms enduring social bonds between mates and displays biparental behavior. Over two decades of research on this species has enhanced our understanding of the neurobiological basis not only of monogamy, social attachment and nurturing behaviors but...

journal_title：Trends in neurosciences

authors： McGraw LA,Young LJ

更新日期：2010-02-01 00:00:00

abstract：:Axonal transport is critical for neuronal homeostasis and relies on motor complexes bound to cargoes via specific adaptors. However, the mechanisms responsible for the spatiotemporal regulation of axonal transport are not completely understood. A recent study by Liao et al. contributes to filling this gap by reporting...

journal_title：Trends in neurosciences

authors： Fratta P,Birsa N,Tosolini AP,Schiavo G

更新日期：2020-01-01 00:00:00

abstract：:Most neurons are generated during development and are not replaced during adulthood, even if they are lost to injury or disease. However, it is firmly established that new neurons are generated in the dentate gyrus of the hippocampus of almost all adult mammals, including humans. Nevertheless, many questions remain re...

journal_title：Trends in neurosciences

authors： Inta D,Cameron HA,Gass P

更新日期：2015-09-01 00:00:00

abstract：:The complex issue of translating the planning of arm movements into muscle forces is discussed in relation to the recent discovery of structures in the spinal cord. These structures contain circuitry that, when activated, produce precisely balanced contractions in groups of muscles. These synergistic contractions gene...

journal_title：Trends in neurosciences

authors： Bizzi E,Giszter SF,Loeb E,Mussa-Ivaldi FA,Saltiel P

更新日期：1995-10-01 00:00:00

abstract：:Despite extensive information on many aspects of peptide neurobiology, the links between the behavioral effects of neuropeptides and their actions at the cellular and molecular levels are not fully understood. A pair of insect neuropeptides, the cardioacceleratory peptides (CAPs) of the tobacco hawkmoth Manduca sexta,...

journal_title：Trends in neurosciences

authors： Tublitz N,Brink D,Broadie KS,Loi PK,Sylwester AW

更新日期：1991-06-01 00:00:00

abstract：:The discovery of genetic forms of Parkinson's disease (PD) has highlighted the importance of the autophagy/lysosomal and mitochondrial/oxidative stress pathways in disease pathogenesis. However, recently identified PD-linked genes, including DNAJC6 (auxilin), SYNJ1 (synaptojanin 1), and the PD risk gene SH3GL2 (endoph...

journal_title：Trends in neurosciences

authors： Nguyen M,Wong YC,Ysselstein D,Severino A,Krainc D

更新日期：2019-02-01 00:00:00

abstract：:The marriage of cognitive neurophysiology and mathematical psychology to understand decision-making has been exceptionally productive. This interdisciplinary area is based on the proposition that particular neurons or circuits instantiate the accumulation of evidence specified by mathematical models of sequential samp...

journal_title：Trends in neurosciences

authors： Schall JD

更新日期：2019-12-01 00:00:00

abstract：:Information that is congruent with existing knowledge (a schema) is usually better remembered than less congruent information. Only recently, however, has the role of schemas in memory been studied from a systems neuroscience perspective. Moreover, incongruent (novel) information is also sometimes better remembered. H...

journal_title：Trends in neurosciences

authors： van Kesteren MT,Ruiter DJ,Fernández G,Henson RN

更新日期：2012-04-01 00:00:00

abstract：:Diverse human disorders, including the majority of neurodegenerative diseases, are thought to arise from the misfolding and aggregation of protein. We have recently described a novel technology to amplify cyclically misfolded proteins in vitro. This procedure, named protein misfolding cyclic amplification (PMCA), is c...

journal_title：Trends in neurosciences

authors： Soto C,Saborio GP,Anderes L

更新日期：2002-08-01 00:00:00

abstract：:Gliomas are terrifying primary brain tumors for which patient outlook remains bleak. Recent research provides novel insights into the unique biology of gliomas. For example, these tumors exhibit an unexpected pluripotency that enables them to grow their own vasculature. They have an unusual ability to navigate tortuou...

journal_title：Trends in neurosciences

authors： Watkins S,Sontheimer H

更新日期：2012-09-01 00:00:00

abstract：:Recently, two large multigene families of putative G-protein-linked receptors that are expressed in distinct subpopulations of neurones in the vomeronasal organ have been identified. These receptors probably mediate pheromone detection. The most surprising aspects of these findings are that there are so many receptors...

journal_title：Trends in neurosciences

authors： Tirindelli R,Mucignat-Caretta C,Ryba NJ

更新日期：1998-11-01 00:00:00

abstract：:Volumetric measurements of the brain regions in eight-year-old children indicate that the poor cognitive and behavioral outcomes noted in ex-preterm neonates are associated with reduced volumes of specific regions in the brain. Recent literature suggests that this reduction might result from enhanced apoptosis or exci...

journal_title：Trends in neurosciences

authors： Bhutta AT,Anand KJ

更新日期：2001-03-01 00:00:00

abstract：:Release probability (P) appears to be a major factor that influences the pattern of transmitter release. At cortical pyramidal axon inputs onto different classes of target cells, very different release patterns are observed, patterns that correlate with release probability. Simplistically, 'low P' synapses display fac...

journal_title：Trends in neurosciences

authors： Thomson AM

更新日期：2000-07-01 00:00:00

abstract：:The proportional relation between circulating vasopressin concentration and plasma osmolality is fundamental for body fluid homeostasis. Although changes in the sensitivity of this relation are associated with pathophysiological conditions, central mechanisms modulating osmoregulatory gain are unknown. Here, we review...

journal_title：Trends in neurosciences

authors： Prager-Khoutorsky M,Bourque CW

更新日期：2010-02-01 00:00:00

abstract：:The human brain can be stimulated by a single intense magnetic pulse over the scalp. Currents induced within the cranium excite the motor cortex and cause limb muscles to contract. The discharge of single motor units, the firing of which is maintained by voluntary effort, can be modulated by magnetic stimuli. Peri-sti...

journal_title：Trends in neurosciences

authors： Mills KR

更新日期：1991-09-01 00:00:00

abstract：:Brain dynamic changes associated with schizophrenia are largely equivocal, with interpretation complicated by many factors, such as the presence of therapeutic agents and the complex nature of the syndrome itself. Evidence for a brain-wide change in individual network oscillations, shared by all patients, is largely e...

journal_title：Trends in neurosciences

authors： Hunt MJ,Kopell NJ,Traub RD,Whittington MA

更新日期：2017-06-01 00:00:00

abstract：:Rather than merely a nuisance, noise in biological systems is a useful property. Before patch-clamp methods were invented, analysis of membrane current noise provided the first solid, if indirect, evidence for the existence of ion-conducting pores with discrete conductance levels. Although supplanted by single-channel...

journal_title：Trends in neurosciences

authors： Traynelis SF,Jaramillo F

更新日期：1998-04-01 00:00:00

abstract：:Compromise of the ubiquitin-proteasome system (UPS) is a potential basis for multiple physiological abnormalities and pathologies in the CNS. This could be because reduced protein turnover leads to bulk intracellular protein accumulation. However, conditions associated with compromised UPS function are also associated...

journal_title：Trends in neurosciences

authors： Ding Q,Cecarini V,Keller JN

更新日期：2007-01-01 00:00:00

abstract：:A general assay for evaluating functional interactions between ligands and G-protein-coupled receptors within minutes has been developed. The system uses the principles employed by animals such as reptiles, amphibians and fish to control their colors. In nature, activation of G-protein-coupled receptors expressed by s...

journal_title：Trends in neurosciences

authors： Lerner MR

更新日期：1994-04-01 00:00:00