Abstract:
:Brain dynamic changes associated with schizophrenia are largely equivocal, with interpretation complicated by many factors, such as the presence of therapeutic agents and the complex nature of the syndrome itself. Evidence for a brain-wide change in individual network oscillations, shared by all patients, is largely equivocal, but stronger for lower (delta) than for higher (gamma) bands. However, region-specific changes in rhythms across multiple, interdependent, nested frequencies may correlate better with pathology. Changes in synaptic excitation and inhibition in schizophrenia disrupt delta rhythm-mediated cortico-cortical communication, while enhancing thalamocortical communication in this frequency band. The contrasting relationships between delta and higher frequencies in thalamus and cortex generate frequency mismatches in inter-regional connectivity, leading to a disruption in temporal communication between higher-order brain regions associated with mental time travel.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Hunt MJ,Kopell NJ,Traub RD,Whittington MAdoi
10.1016/j.tins.2017.04.003subject
Has Abstractpub_date
2017-06-01 00:00:00pages
371-382issue
6eissn
0166-2236issn
1878-108Xpii
S0166-2236(17)30070-Xjournal_volume
40pub_type
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