Abstract:
:In the central nervous system (CNS) the function of retinoic acid, the active metabolite of vitamin A, is best understood from its action in guiding embryonic development; as development comes to completion, retinoic acid signaling declines. However, it is increasingly recognized that this signaling mechanism does not disappear in the adult brain but becomes more regionally focused and takes on new roles. These functions are often tied to processes of neural plasticity whether in the hippocampus, through homeostatic neural plasticity, the olfactory bulb or the hypothalamus. The role of retinoic acid in the control of plastic processes has led to suggestions of its involvement in neural disorders, both degenerative and psychiatric. This review presents a snapshot of developments in these areas over recent years.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Shearer KD,Stoney PN,Morgan PJ,McCaffery PJdoi
10.1016/j.tins.2012.08.005subject
Has Abstractpub_date
2012-12-01 00:00:00pages
733-41issue
12eissn
0166-2236issn
1878-108Xpii
S0166-2236(12)00153-1journal_volume
35pub_type
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