Abstract:
:Notions of what constitutes a neurotransmitter have changed markedly with the advent in the past decade of synaptic molecules, which satisfy key neurotransmitter criteria but differ radically from classical transmitters. Thus, NO and carbon monoxide are neither stored in synaptic vesicles nor released by exocytosis. These gases do not act via traditional receptors on postsynaptic membranes. In addition, zinc, stored together with glutamate in synaptic vesicles, appears to act as an 'antagonist' co-transmitter at the NMDA receptor, and although localized exclusively to glia, D-serine fulfills most neurotransmitter criteria as an endogenous ligand for the 'glycine' site of NMDA receptors.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Barañano DE,Ferris CD,Snyder SHdoi
10.1016/s0166-2236(00)01716-1subject
Has Abstractpub_date
2001-02-01 00:00:00pages
99-106issue
2eissn
0166-2236issn
1878-108Xpii
S0166-2236(00)01716-1journal_volume
24pub_type
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