Abstract:
:The dopaminergic system exerts dynamic modulation of glutamatergic afferent drive that is dependent on the temporal pattern of the dopaminergic input and the subtypes of striatal neurons affected. The differences in feedforward inhibition between striatal neurons comprising the direct and indirect output pathway confer distinct response-pattern differences in their respective targets,supporting brief bursts of activity in Type-I neurons but attenuating repetitive activity in Type-II cells. This temporal patterning is further modulated by NO-mediated signaling, and by tonic and phasic dopamine-mediated stimulation, which exerts preferential actions on indirect and direct output neurons, respectively. As a result,the striatal network is forced into state-dependent patterns of activity that differentially regulate muscle tone and voluntary motor activity via distinct output projections from the striatum.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Onn SP,West AR,Grace AAdoi
10.1016/s1471-1931(00)00020-3subject
Has Abstractpub_date
2000-10-01 00:00:00pages
S48-56issue
10 Suppleissn
0166-2236issn
1878-108Xpii
S1471-1931(00)00020-3journal_volume
23pub_type
杂志文章,评审abstract::Hormonal effects are increasingly recognized as important influences on neuronal function and, ultimately, on animal behavior. Such 'higher' behavioral effects are well studied, particularly in relation to sexually dimorphic behaviors. Yet, somewhat surprisingly, a significant proportion of more basic neuroscience res...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/0166-2236(92)90048-d
更新日期:1992-09-01 00:00:00
abstract::Conditioning and extinction of fear have traditionally been viewed as two independent learning processes for encoding representations of contexts or cues (conditioned stimuli, CS), aversive events (unconditioned stimuli, US), and their relationship. Based on the analysis of protein kinase signaling patterns in neurons...
journal_title:Trends in neurosciences
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abstract::A variety of fatty acids regulate the activity of specific ion channels by mechanisms not involving the enzymatic pathways that convert arachidonic acid to oxygenated metabolites. Furthermore, these actions of fatty acids occur in patches of membrane excised from the cell and are not mediated by cellular signal transd...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/0166-2236(91)90069-7
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journal_title:Trends in neurosciences
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journal_title:Trends in neurosciences
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abstract::Discovery and interventions for neurological disorders have a unique capacity to galvanize public opinion over issues of access, human rights, decision making, and the definition of disease. Here we highlight five cases where beliefs and politics prevailed over evidence and ethics. We examine lessons from them about t...
journal_title:Trends in neurosciences
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journal_title:Trends in neurosciences
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abstract::The birth of new neurons in the walls of the adult brain lateral ventricles has captured the attention of many neuroscientists for over 2 decades, yielding key insights into the identity and regulation of neural stem cells (NSCs). In the adult ventricular-subventricular zone (V-SVZ), NSCs are a specialized form of ast...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
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更新日期:2014-10-01 00:00:00
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journal_title:Trends in neurosciences
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journal_title:Trends in neurosciences
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更新日期:1995-10-01 00:00:00
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
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abstract::How the brain becomes lateralized is poorly understood. By contrast, much is known about molecular cues that specify the left-right axis of the body, fashioning the asymmetric morphology and positioning of the visceral organs. In zebrafish, the Nodal signaling pathway functions in visceral asymmetry and also in the em...
journal_title:Trends in neurosciences
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journal_title:Trends in neurosciences
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更新日期:2019-04-01 00:00:00
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journal_title:Trends in neurosciences
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
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journal_title:Trends in neurosciences
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journal_title:Trends in neurosciences
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journal_title:Trends in neurosciences
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journal_title:Trends in neurosciences
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