Abstract:
:The subunit switching of ligand-gated receptors is a potentially important mechanism through which synaptic plasticity can be achieved in the nervous system. Although established in an activity-dependent manner for neurotransmission that is mediated by excitatory amino acids, there is much less direct evidence for a role of subunit switching in long-term plasticity of GABAA receptors in the adult. We argue that the hypothalamic oxytocin neurones, which exhibit marked plasticity through each reproductive cycle, provide an excellent model of both presynaptic and postsynaptic long-term plasticity of GABA-mediated transmission in the mature nervous system. The postsynaptic plasticity involves GABAA-receptor-subunit switching in an activity-independent manner. It also has profound effects on the electrical behaviour of the oxytocin neurones and, thus, the neural control of pregnancy and lactation.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Brussaard AB,Herbison AEdoi
10.1016/s0166-2236(99)01540-4subject
Has Abstractpub_date
2000-05-01 00:00:00pages
190-5issue
5eissn
0166-2236issn
1878-108Xpii
S0166-2236(99)01540-4journal_volume
23pub_type
杂志文章,评审abstract::The complex issue of translating the planning of arm movements into muscle forces is discussed in relation to the recent discovery of structures in the spinal cord. These structures contain circuitry that, when activated, produce precisely balanced contractions in groups of muscles. These synergistic contractions gene...
journal_title:Trends in neurosciences
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doi:10.1016/0166-2236(95)94494-p
更新日期:1995-10-01 00:00:00
abstract::Nearly 30 years ago, a debate over two disparate models of synaptic vesicle retrieval arose. Subsequent investigations to determine which model was correct proved inconclusive and served only to further the debate. However, recent evidence has begun to suggest that both models are valid and relevant in understanding t...
journal_title:Trends in neurosciences
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doi:10.1016/s0166-2236(00)01769-0
更新日期:2001-04-01 00:00:00
abstract::The dopaminergic system exerts dynamic modulation of glutamatergic afferent drive that is dependent on the temporal pattern of the dopaminergic input and the subtypes of striatal neurons affected. The differences in feedforward inhibition between striatal neurons comprising the direct and indirect output pathway confe...
journal_title:Trends in neurosciences
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abstract::Activation of the complement system has been reported in a variety of inflammatory diseases and neurodegenerative processes of the CNS. Recent evidence indicates that complement proteins and receptors are synthesized on or by glial cells and, surprisingly, neurons. Among these proteins are the receptors for the chemot...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(98)01390-3
更新日期:1999-09-01 00:00:00
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2008.08.005
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abstract::The recent advent of novel high-resolution imaging methods has created a flurry of exciting observations that address a century-old question: what are biological signals that regulate formation and elimination of dendritic spines? Contrary to the traditional belief that the spine is a stable storage site of long-term ...
journal_title:Trends in neurosciences
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doi:10.1016/s0166-2236(99)01499-x
更新日期:2000-02-01 00:00:00
abstract::Active feedback mechanisms in the ears of mammals amplify and tune the auditory response to sound stimuli, allowing these organisms to enjoy both exquisite sensitivity and sharp frequency selectivity. A requisite component of this feedback pathway has recently been identified. Targeted deletion of pres, the gene that ...
journal_title:Trends in neurosciences
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doi:10.1016/S0166-2236(03)00030-4
更新日期:2003-03-01 00:00:00
abstract::Imagine the decisions you might make while playing a simple game like 'matching pennies'. At each play, you and your opponent, say the mathematician John vonNeumann, each lay down a penny heads or tails up. If both pennies show the same side, vonNeumann wins, if not, you win. Before each play, you have the subjective ...
journal_title:Trends in neurosciences
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更新日期:2001-11-01 00:00:00
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
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journal_title:Trends in neurosciences
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journal_title:Trends in neurosciences
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更新日期:2021-02-01 00:00:00
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/0166-2236(91)90161-m
更新日期:1991-08-01 00:00:00
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更新日期:1991-06-01 00:00:00
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更新日期:2014-09-01 00:00:00
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/0166-2236(94)90087-6
更新日期:1994-04-01 00:00:00
abstract::Glia are the most abundant cell type in the mammalian nervous system and they have vital roles in neural development, function and health. However our understanding of the biology of glia is in its infancy. How do glia develop and interact with neurons? How diverse are glial populations? What are the primary functions...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2005.12.002
更新日期:2006-02-01 00:00:00
abstract::A defining feature of the vertebrate nervous system is the ensheathment of axons by myelin, a multilamellar membrane containing a small group of proteins and an abundance of the galactolipid galactocerebroside (GalC) and its sulfated derivative sulfatide. Several in vitro studies have suggested that these galactolipid...
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
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更新日期:1994-07-01 00:00:00
abstract::Stress is a major trigger of seizures in people with epilepsy. Exposure to stress results in the release of several stress mediators throughout the brain, including the hippocampus, a region sensitive to stress and prone to seizures. Stress mediators interact with their respective receptors to produce distinct effects...
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
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abstract::How should evolution and development build the brain to be capable of flexible and generative cognition? I wish to put forth a 'power-of-two'-based wiring logic that provides the basic computational principle in organizing the microarchitecture of cell assemblies that would readily enable knowledge and adaptive behavi...
journal_title:Trends in neurosciences
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更新日期:2017-03-01 00:00:00
abstract::Ejaculation, although mediated by a spinal ejaculation generator, is subject to descending supraspinal modulation from several brain regions. 5-Hydroxytryptamine (5-HT or serotonin) is involved in ejaculatory control, with its ejaculation-retarding effects likely to be attributable to activation of 5-HT1B and 5-HT2C r...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
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更新日期:2007-02-01 00:00:00
abstract::The molecular nature of the metabotropic GABA(B) receptor was for some time a mystery, however it was recently discovered that two related G-protein-coupled receptors have to heterodimerize to form the functional GABA(B) receptor at the cell surface. This review discusses the most recent findings in the rapidly expand...
journal_title:Trends in neurosciences
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更新日期:2001-05-01 00:00:00
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
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更新日期:2011-11-01 00:00:00
abstract::Foraging-associated predation risk is a natural problem all prey must face. Fear evolved due to its protective functions, guiding and shaping behaviors that help animals adapt to various ecological challenges. Despite the breadth of risky situations in nature that demand diversity in fear behaviors, contemporary neuro...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
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更新日期:2016-06-01 00:00:00
abstract::Recent opinion surveys suggest that the majority of the public is willing to accept the use of animals in research if high standards of welfare and effective regulation are in place. The public appears unaware that such standards have existed for some time. The scientific community should now re-focus its communicatio...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
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更新日期:2002-03-01 00:00:00
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
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更新日期:1994-10-01 00:00:00