Signaling by cGAS-STING in Neurodegeneration, Neuroinflammation, and Aging.

abstract：:Serotonin is an important neuromodulator associated with a wide range of physiological effects in the central nervous system. The exact mechanisms whereby serotonin influences brain development are not well understood, although studies in invertebrate and vertebrate model organisms are beginning to unravel a regulator...

journal_title：Trends in neurosciences

authors： Daubert EA,Condron BG

更新日期：2010-09-01 00:00:00

abstract：:The fruit fly, Drosophila melanogaster, has become a model for the study of a growing number of human characteristics because of the power of its genetics. Higher cognitive functions, however, might be assumed to be out of reach for the little fly. But the cumulative history of cognitive studies in insects and some of...

journal_title：Trends in neurosciences

authors： Greenspan RJ,van Swinderen B

更新日期：2004-12-01 00:00:00

abstract：:A general assay for evaluating functional interactions between ligands and G-protein-coupled receptors within minutes has been developed. The system uses the principles employed by animals such as reptiles, amphibians and fish to control their colors. In nature, activation of G-protein-coupled receptors expressed by s...

journal_title：Trends in neurosciences

authors： Lerner MR

更新日期：1994-04-01 00:00:00

abstract：:A key problem in developmental neurobiology is how axons home in on their correct target tissue and establish the correct synaptic contacts. Recent work shows that in the developing Drosophila visual system a population of distinct lamina glial cells ensures correct target layer selection of retinal axons. In the abse...

journal_title：Trends in neurosciences

authors： Pielage J,Klämbt C

更新日期：2001-08-01 00:00:00

abstract：:Motoneurones are known to die (1) during embryonic development (naturally occurring cell death), (2) early in postnatal development after axonal injury, and (3) as a consequence of disease, such as spinal muscular atrophy or (in later life) amyotrophic lateral sclerosis. Naturally occurring motoneurone death has been ...

journal_title：Trends in neurosciences

authors： Lowrie MB,Vrbová G

更新日期：1992-03-01 00:00:00

abstract：:Hebbian synaptic learning requires co-activation of presynaptic and postsynaptic neurons. However, under some conditions, information regarding the postsynaptic action potential, carried by backpropagating action potentials, can be strongly degraded before it reaches the distal exhibit Hebbian long-term potentiation (...

journal_title：Trends in neurosciences

authors： Mehta MR

更新日期：2004-02-01 00:00:00

abstract：:Voltage-dependent Ca2+ channels are one of the main routes for the entry of Ca2+ into excitable cells. These channels are unique in cell-signalling terms in that they can transduce an electrical signal (membrane depolarization) via Ca2+ entry into a chemical signal, by virtue of the diverse range of intracellular Ca(2...

journal_title：Trends in neurosciences

authors： Dolphin AC

更新日期：1996-01-01 00:00:00

abstract：:Complement proteins are ancient components of innate immunity that have emerged as crucial regulators of neural networks. We discuss these roles in the context of the CNS development, acute CNS viral infections, and post-infectious and noninfectious CNS disorders, with an emphasis on microglia-mediated loss of synapse...

journal_title：Trends in neurosciences

authors： Kanmogne M,Klein RS

更新日期：2021-02-01 00:00:00

abstract：:Discovery and interventions for neurological disorders have a unique capacity to galvanize public opinion over issues of access, human rights, decision making, and the definition of disease. Here we highlight five cases where beliefs and politics prevailed over evidence and ethics. We examine lessons from them about t...

journal_title：Trends in neurosciences

authors： Paylor B,Longstaff H,Rossi F,Illes J

更新日期：2014-08-01 00:00:00

abstract：:Speakers of different languages think about time differently in accordance with the spatial metaphors common in their languages. Furthermore, learning new spatial metaphors in language instills new non-linguistic representations of time, suggesting that language can play a causal role in constructing mental timelines....

journal_title：Trends in neurosciences

authors： Boroditsky L

更新日期：2018-10-01 00:00:00

abstract：:ATP-sensitive K+ channels couple cell metabolism to electrical activity in nerve, muscle and endocrine cells, and play important roles in these tissues under both physiological and pathological conditions. The KATP channel is an octameric complex of two unrelated types of subunit: a pore-forming subunit (Kir6.2) and a...

journal_title：Trends in neurosciences

authors： Ashcroft FM,Gribble FM

更新日期：1998-07-01 00:00:00

abstract：:Axonal transport is critical for neuronal homeostasis and relies on motor complexes bound to cargoes via specific adaptors. However, the mechanisms responsible for the spatiotemporal regulation of axonal transport are not completely understood. A recent study by Liao et al. contributes to filling this gap by reporting...

journal_title：Trends in neurosciences

authors： Fratta P,Birsa N,Tosolini AP,Schiavo G

更新日期：2020-01-01 00:00:00

abstract：:CNS myelin inhibits axonal outgrowth in vitro and is one of several obstacles to functional recovery following spinal cord injury. Central to our current understanding of myelin-mediated inhibition are the membrane protein Nogo and the Nogo-66 receptor (NgR). New findings implicate NgR as a point of convergence in sig...

journal_title：Trends in neurosciences

authors： McGee AW,Strittmatter SM

更新日期：2003-04-01 00:00:00

abstract：:The ACh hydrolyzing enzyme acetylcholinesterase (AChE) is a combinatorial series of proteins with variant N and C termini generated from alternate promoter usage and 3' alternative splicing. Neuronal AChE variants show indistinguishable enzymatic activity yet differ in their expression, multimeric assembly and membran...

journal_title：Trends in neurosciences

authors： Meshorer E,Soreq H

更新日期：2006-04-01 00:00:00

abstract：:Repair of adult 'point-to-point' systems by neural grafting is possible only when grafted neurons succeed in synaptically replacing the host's missing neurons, thus re-establishing the anatomical and functional integrity of the impaired circuits. Grafting experiments carried out on the cerebellum of the adult pcd (Pur...

journal_title：Trends in neurosciences

authors： Sotelo C,Alvarado-Mallart RM

更新日期：1991-08-01 00:00:00

abstract：:GABAergic interneurons innervating the perisomatic region of pyramidal cells control population discharge patterns, and thereby all cognitive operations in the cerebral cortex. A striking dichotomy in the function of this interneuron population seems to emerge from the synthesis of recent molecular, anatomical and ele...

journal_title：Trends in neurosciences

authors： Freund TF

更新日期：2003-09-01 00:00:00

abstract：:The precise modulation of regional cerebral blood flow during neural activation is important for matching local energetic demand and supply and clearing brain metabolites. Here we discuss advances facilitated by high-resolution optical in vivo imaging techniques that for the first time have provided direct visualizati...

journal_title：Trends in neurosciences

authors： Grutzendler J,Nedergaard M

更新日期：2019-08-01 00:00:00

abstract：:Relief from pain in humans is rewarding and pleasurable. Primary rewards, or reward-predictive cues, are encoded in brain reward/motivational circuits. While considerable advances have been made in our understanding of reward circuits underlying positive reinforcement, less is known about the circuits underlying the h...

journal_title：Trends in neurosciences

authors： Navratilova E,Atcherley CW,Porreca F

更新日期：2015-11-01 00:00:00

abstract：:Until recently, learning and memory in invertebrate organisms was believed to be mediated by relatively simple presynaptic mechanisms. By contrast, learning and memory in vertebrate organisms is generally thought to be mediated, at least in part, by postsynaptic mechanisms. But new experimental evidence from research ...

journal_title：Trends in neurosciences

authors： Roberts AC,Glanzman DL

更新日期：2003-12-01 00:00:00

abstract：:The majority of Alzheimer's disease is inherited in a complex manner involving environmental factors and several genes. One of these genes is Apolipoprotein E where the polymorphic allele (APOE epsilon 4) has been robustly shown to modify risk and the course of Alzheimer's disease. The epsilon 4 allele however, only a...

journal_title：Trends in neurosciences

authors： Lendon C,Craddock N

更新日期：2001-10-01 00:00:00

abstract：:The molecular and cellular mechanisms by which plasticity is induced in the mature CNS (and, specifically, in the hippocampus) by environmental input are progressively being elucidated. However, the mechanisms - and even the existence - of functional and structural effects of environmental input (and, particularly, st...

journal_title：Trends in neurosciences

authors： Avishai-Eliner S,Brunson KL,Sandman CA,Baram TZ

更新日期：2002-10-01 00:00:00

abstract：:A defining feature of the vertebrate nervous system is the ensheathment of axons by myelin, a multilamellar membrane containing a small group of proteins and an abundance of the galactolipid galactocerebroside (GalC) and its sulfated derivative sulfatide. Several in vitro studies have suggested that these galactolipid...

journal_title：Trends in neurosciences

authors： Coetzee T,Suzuki K,Popko B

更新日期：1998-03-01 00:00:00

abstract：:Recently, two large multigene families of putative G-protein-linked receptors that are expressed in distinct subpopulations of neurones in the vomeronasal organ have been identified. These receptors probably mediate pheromone detection. The most surprising aspects of these findings are that there are so many receptors...

journal_title：Trends in neurosciences

authors： Tirindelli R,Mucignat-Caretta C,Ryba NJ

更新日期：1998-11-01 00:00:00

abstract：:There is compelling evidence linking bradykinin (BK) with the pathophysiological processes that accompany tissue damage and inflammation, especially the production of pain and hyperalgesia. Several mechanisms have been proposed to account for hyperalgesia including the direct activation of nociceptors as well as sensi...

journal_title：Trends in neurosciences

authors： Dray A,Perkins M

更新日期：1993-03-01 00:00:00

abstract：:Rett syndrome is a neurodevelopmental disorder that primarily affects females and is caused by mutations in the methyl-CpG-binding-protein 2 (MECP2) gene. Initially, MeCP2 had been shown to be a repressor of gene transcription. In their 2008 paper, Chahrour and colleagues (DOI: 10.1126/science.1153252) reported that M...

journal_title：Trends in neurosciences

authors： Horvath PM,Monteggia LM

更新日期：2018-02-01 00:00:00

abstract：:The activation of peripheral nociceptors is the subject of intense scrutiny, because of its significance in pain regulation. Genetic approaches, including homology cloning, difference cloning and transgenic manipulation of mice are providing useful insights into nociceptor function. Recent work suggests that transcrip...

journal_title：Trends in neurosciences

authors： Akopian AN,Abson NC,Wood JN

更新日期：1996-06-01 00:00:00

abstract：:Neural tube closure fails in both mouse and Xenopus when dishevelled and other components of the planar-cell-polarity pathway are misregulated. The underlying defect involves a failure of convergent extension in the midline of the early neural plate. Although bilateral neural folds form, they are abnormally far apart ...

journal_title：Trends in neurosciences

authors： Copp AJ,Greene ND,Murdoch JN

更新日期：2003-09-01 00:00:00

abstract：:Dynamic alterations in the structure of the neuronal cytoskeleton are necessary for axonal growth and guidance during development and may also be involved in modulation of synaptic function. Recent evidence suggests that the structural and mechanochemical properties of the cytoskeletal protein, actin, are critical to ...

journal_title：Trends in neurosciences

authors： Forscher P

更新日期：1989-11-01 00:00:00

abstract：:Strong evidence has been provided that ATP can act as a transmitter not only in smooth muscle but also in peripheral ganglia and in brain. The cloning and molecular identification of two putative ATP receptors supports the previously established pharmacological receptor classifications. This review places into perspec...

journal_title：Trends in neurosciences

authors： Zimmermann H

更新日期：1994-10-01 00:00:00

abstract：:The existence of an endogenous cannabinoid system was demonstrated conclusively with the discovery of endogenous brain constituents capable of activating the cannabinoid receptors functionally. These compounds are synthesized by neuronal cells and inactivated through re-uptake and enzymatic hydrolysis by both neurons ...

journal_title：Trends in neurosciences

authors： Di Marzo V,Melck D,Bisogno T,De Petrocellis L

更新日期：1998-12-01 00:00:00