Abstract:
:The ACh hydrolyzing enzyme acetylcholinesterase (AChE) is a combinatorial series of proteins with variant N and C termini generated from alternate promoter usage and 3' alternative splicing. Neuronal AChE variants show indistinguishable enzymatic activity yet differ in their expression, multimeric assembly and membrane-association patterns. Differentially induced under stress, they show distinct non-hydrolytic properties and interact with different protein partners. Recent findings suggest that transcriptional and post-transcriptional regulation of AChE pre-mRNA is a neuroprotection strategy but might involve long-term damage. Specifically, variant-specific causal involvement of AChE in the progression of both neurodegenerative diseases (e.g. Alzheimer's and Parkinson's diseases) and neuromuscular syndromes (e.g. myasthenia gravis) raises the possibility that future therapeutic drugs might target specific AChE variant(s) or the corresponding RNA transcripts.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Meshorer E,Soreq Hdoi
10.1016/j.tins.2006.02.005subject
Has Abstractpub_date
2006-04-01 00:00:00pages
216-24issue
4eissn
0166-2236issn
1878-108Xpii
S0166-2236(06)00044-0journal_volume
29pub_type
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journal_title:Trends in neurosciences
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