Abstract:
:Mossy fiber (MF) synapses are key stations for flow of information through the hippocampal formation. A major component of the output of the MF system is directed towards inhibitory interneurons. Recent studies have revealed that the functional properties of MF-interneuron synapses differ substantially from those of MF-CA3 pyramidal neuron synapses. Mossy-fiber-interneuron synapses in the stratum lucidum represent a continuum of functional subtypes, in which the subunit composition of postsynaptic AMPA receptors and NMDA receptors appears to be regulated in a coordinated manner.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Bischofberger J,Jonas Pdoi
10.1016/s0166-2236(02)02259-2subject
Has Abstractpub_date
2002-12-01 00:00:00pages
600-3issue
12eissn
0166-2236issn
1878-108Xpii
S0166-2236(02)02259-2journal_volume
25pub_type
杂志文章,评审abstract::Mitochondrial dysfunction has been implicated in the pathogenesis of almost all neurological diseases, including Alzheimer's disease (AD). Historically, a primary focus in this context has been the link between mitochondrial dynamics and amyloid β toxicity. Recent evidence suggests that dysregulation of mitochondrial ...
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journal_title:Trends in neurosciences
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