Chemosensory transduction in eukaryotic microorganisms: trends for neuroscience?

Abstract:

:It might appear curious to read about yeast, slime molds and protozoa in a journal dedicated to neuroscience. However, despite their distinct lack of synapses, eukaryotic microorganisms hold a wealth of information relevant to the signal-transduction pathways that underly activity in neuronal receptor cells, particularly those subserving the chemical senses. Microorganisms are sensitive to chemical stimuli from their environment and thus have similarities to receptor neurons of the olfactory system and the taste bud. Here, we introduce receptors, second messengers and effectors responsible for chemosensory signal transduction in yeast mating, sea-urchin spermatozoan chemotaxis, slime-mold aggregation and development, and ciliate chemoresponses.

journal_name

Trends Neurosci

journal_title

Trends in neurosciences

authors

Van Houten J

doi

10.1016/0166-2236(94)90076-0

subject

Has Abstract

pub_date

1994-02-01 00:00:00

pages

62-71

issue

2

eissn

0166-2236

issn

1878-108X

pii

0166-2236(94)90076-0

journal_volume

17

pub_type

杂志文章,评审
  • Nitric oxide and autonomic control of heart rate: a question of specificity.

    abstract::Despite its highly diffusible nature, the gaseous signalling molecule nitric oxide (NO) can exert specific effects within the CNS and PNS. To date, the specificity of the actions of NO remains an unsolved puzzle. There are several plausible mechanisms that might account for this specificity in the context of autonomic...

    journal_title:Trends in neurosciences

    pub_type: 杂志文章,评审

    doi:10.1016/s0166-2236(02)02261-0

    authors: Paton JF,Kasparov S,Paterson DJ

    更新日期:2002-12-01 00:00:00

  • Modular organization of motor behavior in the frog's spinal cord.

    abstract::The complex issue of translating the planning of arm movements into muscle forces is discussed in relation to the recent discovery of structures in the spinal cord. These structures contain circuitry that, when activated, produce precisely balanced contractions in groups of muscles. These synergistic contractions gene...

    journal_title:Trends in neurosciences

    pub_type: 杂志文章,评审

    doi:10.1016/0166-2236(95)94494-p

    authors: Bizzi E,Giszter SF,Loeb E,Mussa-Ivaldi FA,Saltiel P

    更新日期:1995-10-01 00:00:00

  • Acid-sensing ion channels: advances, questions and therapeutic opportunities.

    abstract::Extracellular acid can have important effects on neuron function. In central and peripheral neurons, acid-sensing ion channels (ASICs) have emerged as key receptors for extracellular protons, and recent studies suggest diverse roles for these channels in the pathophysiology of pain, ischemic stroke and psychiatric dis...

    journal_title:Trends in neurosciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tins.2006.06.014

    authors: Wemmie JA,Price MP,Welsh MJ

    更新日期:2006-10-01 00:00:00

  • Imaging synaptic zinc: promises and perils.

    abstract::It is well established that some excitatory nerve terminals have high concentrations of Zn(2+) in their synaptic vesicles. For some time, it has been believed that synaptic Zn(2+) is released during neurotransmission and acts as a neuromodulator. Fluorescent Zn(2+) indicators that do not penetrate membranes offer the ...

    journal_title:Trends in neurosciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tins.2006.02.004

    authors: Kay AR

    更新日期:2006-04-01 00:00:00

  • Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype?

    abstract::Gene targeting to create null mutations in mice is a powerful new tool in biology which will allow the molecular dissection of complex phenotypes such as mammalian brain function, and learning and memory. However, the attempt to interpret the phenotypical changes which arise in null-mutant mice is subject to several c...

    journal_title:Trends in neurosciences

    pub_type: 杂志文章

    doi:10.1016/s0166-2236(96)20020-7

    authors: Gerlai R

    更新日期:1996-05-01 00:00:00

  • Tools for investigating functional interactions between ligands and G-protein-coupled receptors.

    abstract::A general assay for evaluating functional interactions between ligands and G-protein-coupled receptors within minutes has been developed. The system uses the principles employed by animals such as reptiles, amphibians and fish to control their colors. In nature, activation of G-protein-coupled receptors expressed by s...

    journal_title:Trends in neurosciences

    pub_type: 杂志文章,评审

    doi:10.1016/0166-2236(94)90087-6

    authors: Lerner MR

    更新日期:1994-04-01 00:00:00

  • Neuronal gap junctions: making and breaking connections during development and injury.

    abstract::In the mammalian central nervous system (CNS), coupling of neurons by gap junctions (i.e., electrical synapses) and the expression of the neuronal gap junction protein, connexin 36 (Cx36), transiently increase during early postnatal development. The levels of both subsequently decline and remain low in the adult, conf...

    journal_title:Trends in neurosciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tins.2012.11.001

    authors: Belousov AB,Fontes JD

    更新日期:2013-04-01 00:00:00

  • The GABA nervous system in C. elegans.

    abstract::GABA neurotransmission requires a specialized set of proteins to synthesize, transport or respond to GABA. This article reviews results from a genetic strategy in the nematode Caenorhabditis elegans designed to identify the genes responsible for these activities. These studies identified mutations in genes encoding fi...

    journal_title:Trends in neurosciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tins.2004.05.005

    authors: Schuske K,Beg AA,Jorgensen EM

    更新日期:2004-07-01 00:00:00

  • Organizing pains.

    abstract::Chronic pain is sustained by central neuronal sensitization, with many similar characteristics irrespective of the type of injury incurred. Nevertheless, pain arising from nerve injury (neuropathic pain) is resistant to centrally acting analgesics, whereas inflammatory pain responds well. New research indicates that t...

    journal_title:Trends in neurosciences

    pub_type: 杂志文章

    doi:10.1016/j.tins.2004.03.014

    authors: Garry EM,Fleetwood-Walker SM

    更新日期:2004-06-01 00:00:00

  • Leaning to the left: laterality in the zebrafish forebrain.

    abstract::How the brain becomes lateralized is poorly understood. By contrast, much is known about molecular cues that specify the left-right axis of the body, fashioning the asymmetric morphology and positioning of the visceral organs. In zebrafish, the Nodal signaling pathway functions in visceral asymmetry and also in the em...

    journal_title:Trends in neurosciences

    pub_type: 杂志文章,评审

    doi:10.1016/S0166-2236(03)00129-2

    authors: Halpern ME,Liang JO,Gamse JT

    更新日期:2003-06-01 00:00:00

  • Mutant huntingtin and mitochondrial dysfunction.

    abstract::Huntington's disease (HD) is a fatal, inherited neurodegenerative disorder that gradually robs affected individuals of memory, cognitive skills and normal movements. Although research has identified a single faulty gene, the huntingtin gene, as the cause of the disease, a cure remains elusive. Strong evidence indicate...

    journal_title:Trends in neurosciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tins.2008.09.004

    authors: Bossy-Wetzel E,Petrilli A,Knott AB

    更新日期:2008-12-01 00:00:00

  • Facilitation, augmentation and potentiation at central synapses.

    abstract::Release probability (P) appears to be a major factor that influences the pattern of transmitter release. At cortical pyramidal axon inputs onto different classes of target cells, very different release patterns are observed, patterns that correlate with release probability. Simplistically, 'low P' synapses display fac...

    journal_title:Trends in neurosciences

    pub_type: 杂志文章,评审

    doi:10.1016/s0166-2236(00)01580-0

    authors: Thomson AM

    更新日期:2000-07-01 00:00:00

  • Evolutionary history of the ligand-gated ion-channel superfamily of receptors.

    abstract::The fast-acting ligand-gated ion channels (LGICs) constitute a group that encompasses nicotinic ACh, 5-HT3, GABAA and glycine receptors. Undoubtedly, they all share a common evolutionary ancestor, and the group can therefore be considered to be a gene superfamily. Because the members of the superfamily are all recepto...

    journal_title:Trends in neurosciences

    pub_type: 杂志文章,评审

    doi:10.1016/0166-2236(95)93887-4

    authors: Ortells MO,Lunt GG

    更新日期:1995-03-01 00:00:00

  • Hooked on benzodiazepines: GABAA receptor subtypes and addiction.

    abstract::Benzodiazepines are widely used clinically to treat anxiety and insomnia. They also induce muscle relaxation, control epileptic seizures, and can produce amnesia. Moreover, benzodiazepines are often abused after chronic clinical treatment and also for recreational purposes. Within weeks, tolerance to the pharmacologic...

    journal_title:Trends in neurosciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tins.2011.01.004

    authors: Tan KR,Rudolph U,Lüscher C

    更新日期:2011-04-01 00:00:00

  • From behavior to molecules: an integrated approach to the study of neuropeptides.

    abstract::Despite extensive information on many aspects of peptide neurobiology, the links between the behavioral effects of neuropeptides and their actions at the cellular and molecular levels are not fully understood. A pair of insect neuropeptides, the cardioacceleratory peptides (CAPs) of the tobacco hawkmoth Manduca sexta,...

    journal_title:Trends in neurosciences

    pub_type: 杂志文章,评审

    doi:10.1016/0166-2236(91)90126-f

    authors: Tublitz N,Brink D,Broadie KS,Loi PK,Sylwester AW

    更新日期:1991-06-01 00:00:00

  • The c-Jun transcription factor--bipotential mediator of neuronal death, survival and regeneration.

    abstract::Axon interruption elicits a complex neuronal response that leaves neurons poised precariously between death and regeneration. The signals underlying this dichotomy are not fully understood. The transcription factor c-Jun is one of the earliest and most consistent markers for neurons that respond to nerve-fiber transec...

    journal_title:Trends in neurosciences

    pub_type: 杂志文章,评审

    doi:10.1016/s0166-2236(96)01000-4

    authors: Herdegen T,Skene P,Bähr M

    更新日期:1997-05-01 00:00:00

  • Hippocampal neurogenesis and forgetting.

    abstract::The hippocampus is thought to automatically encode all experience, yet the vast majority of our experiences are not remembered later. Although psychological theories have postulated the existence of decay processes for declarative memory, the corresponding neurobiological mechanisms are unknown. Here we develop the hy...

    journal_title:Trends in neurosciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tins.2013.05.002

    authors: Frankland PW,Köhler S,Josselyn SA

    更新日期:2013-09-01 00:00:00

  • Axonal flip-flops and oscillators.

    abstract::The strange and unpleasant sensations (paraesthesiae) or asynchronous motor-unit activation (fasciculation) that result from a period of limb ischaemia are examples of ectopic discharge in peripheral nerves. Ectopic activity also results from demyelination and is associated with serious neurological conditions, such a...

    journal_title:Trends in neurosciences

    pub_type: 杂志文章,评审

    doi:10.1016/s0166-2236(00)01645-3

    authors: Baker MD

    更新日期:2000-11-01 00:00:00

  • Neuronal Ca2+ stores: activation and function.

    abstract::The intracellular concentration of free Ca2+ ([Ca2+]i) displays complex fluctuations in response to a variety of stimuli, and acts as a pluripotent signal for many neuronal functions. It is well established that various 'metabotropic' neurotransmitter receptors can mediate the mobilization of Ca2+ stores via actions o...

    journal_title:Trends in neurosciences

    pub_type: 杂志文章,评审

    doi:10.1016/0166-2236(95)93919-o

    authors: Simpson PB,Challiss RA,Nahorski SR

    更新日期:1995-07-01 00:00:00

  • Unveiling synaptic plasticity: a new graphical and analytical approach.

    abstract::Short-term synaptic plasticity has a key role in information processing in the CNS, whereas memories can be formed through long-lasting changes in synaptic strength. Despite the importance of these phenomena, it remains difficult to determine whether a synaptic modulation is expressed at a presynaptic or postsynaptic ...

    journal_title:Trends in neurosciences

    pub_type: 杂志文章

    doi:10.1016/s0166-2236(99)01520-9

    authors: Clements JD,Silver RA

    更新日期:2000-03-01 00:00:00

  • New laboratory start-up in the 21st century.

    abstract::Launching a new neuroscience laboratory requires knowledge of purchasing, budgeting and personnel management. The usual training of scientific investigators omits these areas, at a time when experimental complexity is growing and Internet-based commerce offers new purchasing options. This review highlights laboratory ...

    journal_title:Trends in neurosciences

    pub_type: 杂志文章

    doi:10.1016/s0166-2236(02)02161-6

    authors: Carmichael ST

    更新日期:2002-06-01 00:00:00

  • Functional localization within the prefrontal cortex: missing the forest for the trees?

    abstract::Anatomical and functional studies of the prefrontal cortex (PFC) have identified multiple PFC subregions. We argue that the PFC is involved in cognitive functions exceeding the sum of specific functions attributed to its subregions. These can be revealed either by lesions of the whole PFC, or more specifically by sele...

    journal_title:Trends in neurosciences

    pub_type: 杂志文章

    doi:10.1016/j.tins.2010.08.001

    authors: Wilson CR,Gaffan D,Browning PG,Baxter MG

    更新日期:2010-12-01 00:00:00

  • Integrins: possible functions in the adult CNS.

    abstract::Integrins comprise a large family of heterodimeric proteins that mediate cell-cell and cell-extracellular-matrix adhesive connections. There is an extensive literature on their importance in neural development and cancer, but evidence for the existence of integrins in the adult CNS has emerged only recently. With grow...

    journal_title:Trends in neurosciences

    pub_type: 杂志文章,评审

    doi:10.1016/0166-2236(96)89623-8

    authors: Jones LS

    更新日期:1996-02-01 00:00:00

  • Learning in Aplysia: looking at synaptic plasticity from both sides.

    abstract::Until recently, learning and memory in invertebrate organisms was believed to be mediated by relatively simple presynaptic mechanisms. By contrast, learning and memory in vertebrate organisms is generally thought to be mediated, at least in part, by postsynaptic mechanisms. But new experimental evidence from research ...

    journal_title:Trends in neurosciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tins.2003.09.014

    authors: Roberts AC,Glanzman DL

    更新日期:2003-12-01 00:00:00

  • Asymmetry Between Pre- and Postsynaptic Transient Nanodomains Shapes Neuronal Communication.

    abstract::Synaptic transmission and plasticity are shaped by the dynamic reorganization of signaling molecules within pre- and postsynaptic compartments. The nanoscale organization of key effector molecules has been revealed by single-particle trajectory (SPT) methods. Interestingly, this nanoscale organization is highly hetero...

    journal_title:Trends in neurosciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tins.2020.01.005

    authors: Heine M,Holcman D

    更新日期:2020-03-01 00:00:00

  • Localization of brain function using magnetic resonance imaging.

    abstract::When nuclear magnetic resonance images (MRIs) of the brain are acquired in rapid succession they exhibit small differences in signal intensity in positions corresponding to focal areas of activation. These signal changes result from small differences in the magnetic resonance signal caused by variations in the oxygena...

    journal_title:Trends in neurosciences

    pub_type: 杂志文章,评审

    doi:10.1016/0166-2236(94)90055-8

    authors: Cohen MS,Bookheimer SY

    更新日期:1994-07-01 00:00:00

  • Smelling Time: A Neural Basis for Olfactory Scene Analysis.

    abstract::Behavioral evidence from phylogenetically diverse animals and from humans suggests that, by extracting temporal information inherent in the olfactory signal, olfaction is more involved in interpreting space and time than heretofore imagined. If this is the case, the olfactory system must have neural mechanisms capable...

    journal_title:Trends in neurosciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tins.2016.08.002

    authors: Ache BW,Hein AM,Bobkov YV,Principe JC

    更新日期:2016-10-01 00:00:00

  • A vitamin for the brain.

    abstract::In the central nervous system (CNS) the function of retinoic acid, the active metabolite of vitamin A, is best understood from its action in guiding embryonic development; as development comes to completion, retinoic acid signaling declines. However, it is increasingly recognized that this signaling mechanism does not...

    journal_title:Trends in neurosciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tins.2012.08.005

    authors: Shearer KD,Stoney PN,Morgan PJ,McCaffery PJ

    更新日期:2012-12-01 00:00:00

  • Pause and rebound: sensory control of cholinergic signaling in the striatum.

    abstract::Cholinergic interneurons have emerged as one of the key players controlling network functions in the striatum. Extracellularly recorded cholinergic interneurons acquire characteristic responses to sensory stimuli during reward-related learning, including a pause and subsequent rebound in spiking. However, the precise ...

    journal_title:Trends in neurosciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tins.2012.09.006

    authors: Schulz JM,Reynolds JN

    更新日期:2013-01-01 00:00:00

  • Transitions in Brain Evolution: Space, Time and Entropy.

    abstract::How did brains evolve to become so complex, and what is their future? Brains pose an explanatory challenge because entropy, which inexorably increases over time, is commonly associated with disorder and simplicity. Recently we showed how evolution is an entropic process, building structures - organisms - which themsel...

    journal_title:Trends in neurosciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.tins.2020.04.008

    authors: Jeffery KJ,Rovelli C

    更新日期:2020-07-01 00:00:00