Abstract:
:Navigation depends upon neural systems that monitor spatial location and head orientation. Recent developmental findings have led some to conclude that these systems are innate. Such claims are premature. But also, there are more meaningful ways to arrive at answers about developmental origins than by invoking the outdated nature-nurture dichotomy.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Blumberg MSdoi
10.1016/j.tins.2015.01.001subject
Has Abstractpub_date
2015-02-01 00:00:00pages
67-8issue
2eissn
0166-2236issn
1878-108Xpii
S0166-2236(15)00002-8journal_volume
38pub_type
杂志文章,评审abstract::Cell replacement therapy has been proposed as a means to replace lost dopaminergic neurons in Parkinson's disease (PD). In most studies, the transplanted cells have been placed within the target site, the striatum, and not within the lesioned site, the substantia nigra, as the adult nigrostriatal pathway was thought t...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2011.01.003
更新日期:2011-03-01 00:00:00
abstract::Chronic pain secondary to neuronal injury is actively and continuously modulated at multiple locations along the sensory neuraxis. Here, we describe how nociceptive neurons of the spinal cord and thalamus process and communicate nociceptive information in terms of precisely calibrated firing patterns. We then discuss ...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2008.11.004
更新日期:2009-02-01 00:00:00
abstract::The molecular nature of the metabotropic GABA(B) receptor was for some time a mystery, however it was recently discovered that two related G-protein-coupled receptors have to heterodimerize to form the functional GABA(B) receptor at the cell surface. This review discusses the most recent findings in the rapidly expand...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(00)01815-4
更新日期:2001-05-01 00:00:00
abstract::Genetic mouse models based on identification of genes that cause Huntington's and Parkinson's diseases have revolutionized understanding of the mechanistic pathophysiological progression of these disorders. These models allow the earliest manifestations of the diseases to be identified, and they display behavioral, ne...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2004.08.008
更新日期:2004-11-01 00:00:00
abstract::Interaural time differences (ITDs) represent an important cue in sound localization and auditory scene analysis. To assess this cue the auditory system internally delays binaural inputs to compensate for the outer delay, before neurons in the brainstem detect the coincident arrival of the inputs from the two ears. Dif...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2014.03.002
更新日期:2014-05-01 00:00:00
abstract::The principal ovarian estrogen, estradiol, and brain-derived neurotrophic factor (BDNF) have widespread effects on the CNS that have usually been studied independently. This article examines the similarities in the effects of estradiol and BDNF in the hippocampus, in light of the evidence that estradiol can induce BDN...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2004.12.005
更新日期:2005-02-01 00:00:00
abstract::A fundamental problem in systems neuroscience is mapping the physical properties of a stimulus to perceptual characteristics. In vision, wavelength translates into color; in audition, frequency translates into pitch. Although odorant concentration is a key feature of olfactory stimuli, we do not know how concentration...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2014.05.005
更新日期:2014-08-01 00:00:00
abstract::The appearance of Santiago Ramón y Cajal in the world of neuroscience provoked a radical change in the course of its history. Cajal's studies of the microanatomy of virtually the whole CNS and his observations regarding degeneration and regeneration, together with his theories about the function, development and plast...
journal_title:Trends in neurosciences
pub_type: 传,历史文章,杂志文章
doi:10.1016/s0166-2236(02)02214-2
更新日期:2002-09-01 00:00:00
abstract::Depression is a common cause of mortality and morbidity, but the biological bases of the deficits in emotional and cognitive processing remain incompletely understood. Current antidepressant therapies are effective in only some patients and act slowly. Here, we propose an excitatory synapse hypothesis of depression in...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2015.03.003
更新日期:2015-05-01 00:00:00
abstract::The dopaminergic system exerts dynamic modulation of glutamatergic afferent drive that is dependent on the temporal pattern of the dopaminergic input and the subtypes of striatal neurons affected. The differences in feedforward inhibition between striatal neurons comprising the direct and indirect output pathway confe...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s1471-1931(00)00020-3
更新日期:2000-10-01 00:00:00
abstract::Release probability (P) appears to be a major factor that influences the pattern of transmitter release. At cortical pyramidal axon inputs onto different classes of target cells, very different release patterns are observed, patterns that correlate with release probability. Simplistically, 'low P' synapses display fac...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(00)01580-0
更新日期:2000-07-01 00:00:00
abstract::Both theoretical and experimental animal work supports the hypothesis that transient oscillatory synchronization of neuronal assemblies at gamma frequencies (30-100 Hz) is closely associated with sensory processing. Recent data from recordings in animals and humans have suggested that gamma-frequency activity also has...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2007.05.001
更新日期:2007-07-01 00:00:00
abstract::Parkinson's disease is a common and disabling disorder of movement owing to dopaminergic denervation of the striatum. However, it is still unclear how this denervation perverts normal functioning to cause slowing of voluntary movements. Recent work using tissue slice preparations, animal models and in humans with Park...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2007.05.004
更新日期:2007-07-01 00:00:00
abstract::Studies of the brain during noxious experience converge on the anterior cingulate cortex as a key region in the processing of pain. A recent exciting study extends this understanding to include the anterior cingulate as a center for endogenous opioid activation specific to negative pain affect. ...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(02)02025-8
更新日期:2002-02-01 00:00:00
abstract::NMDA receptors (NMDARs) are ion channels activated by the excitatory neurotransmitter glutamate and are essential to all aspects of brain function, including learning and memory formation. Missense mutations distributed throughout NMDAR subunits have been associated with an array of neurological disorders. Recent stru...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2017.01.001
更新日期:2017-03-01 00:00:00
abstract::Complement proteins are ancient components of innate immunity that have emerged as crucial regulators of neural networks. We discuss these roles in the context of the CNS development, acute CNS viral infections, and post-infectious and noninfectious CNS disorders, with an emphasis on microglia-mediated loss of synapse...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2020.10.003
更新日期:2021-02-01 00:00:00
abstract::Information that is congruent with existing knowledge (a schema) is usually better remembered than less congruent information. Only recently, however, has the role of schemas in memory been studied from a systems neuroscience perspective. Moreover, incongruent (novel) information is also sometimes better remembered. H...
journal_title:Trends in neurosciences
pub_type: 杂志文章
doi:10.1016/j.tins.2012.02.001
更新日期:2012-04-01 00:00:00
abstract::The use of Drosophila as a suitable system to answer behavioural questions is usually based on the availability of mutant phenotypes. Indeed, the 'single-gene' approach to behaviour was a very illuminating strategy in practical and conceptual terms, and served to prove that the genetic mechanisms sustaining behaviour ...
journal_title:Trends in neurosciences
pub_type: 杂志文章
doi:10.1016/0166-2236(94)90137-6
更新日期:1994-11-01 00:00:00
abstract::Exocytosis in neurones and neuroendocrine cells is triggered by an increase in the cytosolic concentration of Ca2+, and is followed by endocytotic membrane retrieval. Electrophysiological studies have characterized the nature of the Ca2+ signal that is required for exocytosis, and have defined the Ca(2+)-dependent ste...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/0166-2236(95)93900-i
更新日期:1995-04-01 00:00:00
abstract::The fast-acting ligand-gated ion channels (LGICs) constitute a group that encompasses nicotinic ACh, 5-HT3, GABAA and glycine receptors. Undoubtedly, they all share a common evolutionary ancestor, and the group can therefore be considered to be a gene superfamily. Because the members of the superfamily are all recepto...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/0166-2236(95)93887-4
更新日期:1995-03-01 00:00:00
abstract::The construction of artificial walking machines has been a challenging task for engineers for several centuries. Advances in computer technology have stimulated this research in the past two decades, and enormous progress has been made, particularly in recent years. Nevertheless, in comparing the walk of a six-legged ...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/0166-2236(90)90057-h
更新日期:1990-01-01 00:00:00
abstract::The brain includes multiple types of interconnected excitatory and inhibitory neurons that together allow us to move, think, feel, and interact with the environment. Inhibitory interneurons (INs) comprise a small, heterogeneous fraction, but they exert a powerful and tight control over neuronal activity and consequent...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2017.05.004
更新日期:2017-07-01 00:00:00
abstract::A century after the discovery of acetylcholine (ACh), we recognize both ACh receptors, transporters, and synthesizing and degrading enzymes and regulators of their expression as contributors to cognition, metabolism, and immunity. Recent discoveries indicate that pre- and post-transcriptional ACh signaling controllers...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2015.05.007
更新日期:2015-07-01 00:00:00
abstract::Astrocytes, which constitute the most abundant cell type in mammalian brain, are extensively coupled to one another through gap junctions composed mainly of connexin43. In regions exhibiting high levels of connexin43 expression, tens of astrocytes are labeled following single-cell intracellular injection. Importantly,...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/0166-2236(96)10046-1
更新日期:1996-08-01 00:00:00
abstract::The ability of neurons to modulate the strength of their synaptic connections has been shown to depend on the relative timing of pre- and postsynaptic action potentials. This form of synaptic plasticity, called spike-timing-dependent plasticity (STDP), has become an attractive model for learning at the single-cell lev...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2007.06.010
更新日期:2007-09-01 00:00:00
abstract::The physiology of the central nervous system (CNS) is built on a foundation of connection, integration, and the exchange of complex information among brain cells. Emerging evidence indicates that extracellular vesicles (EVs) are key players in the intercellular communication that underlies physiological processes such...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2018.03.006
更新日期:2018-06-01 00:00:00
abstract::Although signs of empathy have now been well documented in non-human primates, only during the past few years have systematic observations suggested that a primal form of empathy exists in rodents. Thus, the study of empathy in animals has started in earnest. Here we review recent studies indicating that rodents are a...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2013.04.009
更新日期:2013-08-01 00:00:00
abstract::Sensory dendrites fall into many different morphological and functional classes. Polymodal nociceptors are one subclass of sensory neurons, which are of particular note owing to their elaborate dendritic arbors. Complex developmental programs are required to form these arbors and there is striking conservation of morp...
journal_title:Trends in neurosciences
pub_type: 杂志文章
doi:10.1016/j.tins.2011.07.004
更新日期:2011-09-01 00:00:00
abstract::Advances in understanding the biology of neurotrophic factors and their signaling pathways have provided important insights into the normal growth, differentiation and maintenance of neurons. Stimulated by neuropathological observations and genetic discoveries, studies in cell and animal models of neurodegenerative di...
journal_title:Trends in neurosciences
pub_type: 杂志文章
doi:10.1016/S0166-2236(02)00038-3
更新日期:2003-02-01 00:00:00
abstract::It is generally thought that monoamines play a nonspecific role in modulating cortical activity. However, several lines of evidence now indicate that cortical monoaminergic afferents show remarkable anatomical specificity. In particular, there is unequivocal evidence for regional, laminar and intracortical specificity...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/0166-2236(89)90037-4
更新日期:1989-09-01 00:00:00