Abstract:
:Parkinson's disease is a common and disabling disorder of movement owing to dopaminergic denervation of the striatum. However, it is still unclear how this denervation perverts normal functioning to cause slowing of voluntary movements. Recent work using tissue slice preparations, animal models and in humans with Parkinson's disease has demonstrated abnormally synchronized oscillatory activity at multiple levels of the basal ganglia-cortical loop. This excessive synchronization correlates with motor deficit, and its suppression by dopaminergic therapies, ablative surgery or deep-brain stimulation might provide the basic mechanism whereby diverse therapeutic strategies ameliorate motor impairment in patients with Parkinson's disease. This review is part of the INMED/TINS special issue, Physiogenic and pathogenic oscillations: the beauty and the beast, based on presentations at the annual INMED/TINS symposium (http://inmednet.com/).
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Hammond C,Bergman H,Brown Pdoi
10.1016/j.tins.2007.05.004subject
Has Abstractpub_date
2007-07-01 00:00:00pages
357-64issue
7eissn
0166-2236issn
1878-108Xpii
S0166-2236(07)00123-3journal_volume
30pub_type
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journal_title:Trends in neurosciences
pub_type: 评论,杂志文章
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journal_title:Trends in neurosciences
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journal_title:Trends in neurosciences
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doi:10.1016/j.tins.2004.12.005
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journal_title:Trends in neurosciences
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journal_title:Trends in neurosciences
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journal_title:Trends in neurosciences
pub_type: 传,历史文章,杂志文章
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journal_title:Trends in neurosciences
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pub_type: 杂志文章,评审
doi:10.1016/j.tins.2012.08.004
更新日期:2012-11-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(02)02059-3
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更新日期:2003-03-01 00:00:00
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journal_title:Trends in neurosciences
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journal_title:Trends in neurosciences
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doi:10.1016/s0166-2236(02)02154-9
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/S0166-2236(96)40005-4
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2009.12.002
更新日期:2010-03-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1016/0166-2236(92)90354-b
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
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doi:10.1016/j.tins.2009.09.001
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
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更新日期:2001-10-01 00:00:00
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