Abstract:
:Life span is determined by both environmental and genetic influences. The importance of genes is illustrated by the fact that single gene mutations extend life span in nematodes, fruit flies and mice. Recent reports reveal that the life span of Caenorhabditis elegans is controlled by insulin-like signals from the nervous system. Hormones that control life span have recently been identified in fruit flies and mice. These findings suggest that neuroendocrine pathways could constitute an important determinant of life span across phylogeny. This review examines the evidence for nervous system control of longevity and discusses the implications for popular models for aging.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Wolkow CAdoi
10.1016/s0166-2236(02)02133-1subject
Has Abstractpub_date
2002-04-01 00:00:00pages
212-6issue
4eissn
0166-2236issn
1878-108Xpii
S0166-2236(02)02133-1journal_volume
25pub_type
杂志文章,评审abstract::Local signaling events at synapses or axon terminals must be communicated to the nucleus to elicit transcriptional responses. The lengths of neuronal processes pose a significant challenge for such intracellular communication. This challenge is met by mechanisms ranging from rapid signals encoded in calcium waves to s...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2014.12.001
更新日期:2015-02-01 00:00:00
abstract::This is a great age to participate in biological inquiry. Behavioral neuroscience offers a rich perspective for molecular biologists. However, behavioral analysis is not simply an assay. Whereas molecular biology has become a unique tool in the armamentarium of behavioral neuroscience, the powerful methodology of mole...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(00)01636-2
更新日期:2000-10-01 00:00:00
abstract::Discovery and interventions for neurological disorders have a unique capacity to galvanize public opinion over issues of access, human rights, decision making, and the definition of disease. Here we highlight five cases where beliefs and politics prevailed over evidence and ethics. We examine lessons from them about t...
journal_title:Trends in neurosciences
pub_type: 杂志文章
doi:10.1016/j.tins.2014.06.001
更新日期:2014-08-01 00:00:00
abstract::Studies of the brain during noxious experience converge on the anterior cingulate cortex as a key region in the processing of pain. A recent exciting study extends this understanding to include the anterior cingulate as a center for endogenous opioid activation specific to negative pain affect. ...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(02)02025-8
更新日期:2002-02-01 00:00:00
abstract::Chronic pain secondary to neuronal injury is actively and continuously modulated at multiple locations along the sensory neuraxis. Here, we describe how nociceptive neurons of the spinal cord and thalamus process and communicate nociceptive information in terms of precisely calibrated firing patterns. We then discuss ...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2008.11.004
更新日期:2009-02-01 00:00:00
abstract::Strong evidence has been provided that ATP can act as a transmitter not only in smooth muscle but also in peripheral ganglia and in brain. The cloning and molecular identification of two putative ATP receptors supports the previously established pharmacological receptor classifications. This review places into perspec...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/0166-2236(94)90016-7
更新日期:1994-10-01 00:00:00
abstract::The laboratory mouse has emerged as a primary model organism for studying axon regeneration after experimental spinal cord injury, owing to its genetic amenability. Mutant mouse models are contributing significantly to our understanding of the molecular mechanisms of axon regeneration failure in the adult mammalian ce...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2006.09.005
更新日期:2006-11-01 00:00:00
abstract::Major themes in neuroethology concern the specificity of key stimuli, neurones tuned to such stimuli, and the release of corresponding behaviour. Neurobiological data from the analysis of visuomotor functions of prey-catching and avoiding in amphibians support the view that retinal outflow in different combinations is...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(96)01042-9
更新日期:1997-08-01 00:00:00
abstract::Opium and its derivatives are potent analgesics that also have many other pharmacological effects in the nervous system. These agents and the endogenous opioid peptides exert their effects by interacting with high-affinity receptors. Complementary DNAs encoding the delta, kappa and mu opioid receptors have been isolat...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/0166-2236(93)90194-q
更新日期:1993-12-01 00:00:00
abstract::Unlike most mammalian species, the prairie vole is highly affiliative, forms enduring social bonds between mates and displays biparental behavior. Over two decades of research on this species has enhanced our understanding of the neurobiological basis not only of monogamy, social attachment and nurturing behaviors but...
journal_title:Trends in neurosciences
pub_type: 杂志文章
doi:10.1016/j.tins.2009.11.006
更新日期:2010-02-01 00:00:00
abstract::'Forward models' are increasingly recognized as a crucial explanatory concept in vertebrate motor control. The essential idea is that an important function implemented by nervous systems is prediction of the sensory consequences of action. This is often associated with higher cognitive capabilities; however, many of t...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2004.03.004
更新日期:2004-05-01 00:00:00
abstract::ATP-sensitive K+ channels couple cell metabolism to electrical activity in nerve, muscle and endocrine cells, and play important roles in these tissues under both physiological and pathological conditions. The KATP channel is an octameric complex of two unrelated types of subunit: a pore-forming subunit (Kir6.2) and a...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(98)01225-9
更新日期:1998-07-01 00:00:00
abstract::Hormonal effects are increasingly recognized as important influences on neuronal function and, ultimately, on animal behavior. Such 'higher' behavioral effects are well studied, particularly in relation to sexually dimorphic behaviors. Yet, somewhat surprisingly, a significant proportion of more basic neuroscience res...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/0166-2236(92)90048-d
更新日期:1992-09-01 00:00:00
abstract::Recent studies of the iconic fall migration of monarch butterflies have illuminated the mechanisms behind their southward navigation while using a time-compensated sun compass. Skylight cues, such as the sun itself and polarized light, are processed through both eyes and are probably integrated in the brain's central ...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2010.04.004
更新日期:2010-09-01 00:00:00
abstract::The strange and unpleasant sensations (paraesthesiae) or asynchronous motor-unit activation (fasciculation) that result from a period of limb ischaemia are examples of ectopic discharge in peripheral nerves. Ectopic activity also results from demyelination and is associated with serious neurological conditions, such a...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(00)01645-3
更新日期:2000-11-01 00:00:00
abstract::An abundance of experimental literature has established that gonadal steroid hormones are responsible for the sexual differentiation of neural circuitry, mediating a variety of reproductive behaviors and physiological mechanisms. These same hormones regulate the expression of reproductive function in the adult and may...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/0166-2236(90)90186-e
更新日期:1990-03-01 00:00:00
abstract::Itch is a distinct sensation arising from the superficial layers of skin and mucous membranes. It is elicited by histamine and probably other endogenous chemicals that excite subpopulations of unmyelinated primary afferents and spinal neurones projecting through the anterolateral quadrant to the brain. The two popular...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/0166-2236(92)90102-e
更新日期:1992-12-01 00:00:00
abstract::Rather than merely a nuisance, noise in biological systems is a useful property. Before patch-clamp methods were invented, analysis of membrane current noise provided the first solid, if indirect, evidence for the existence of ion-conducting pores with discrete conductance levels. Although supplanted by single-channel...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(98)01238-7
更新日期:1998-04-01 00:00:00
abstract::The number of neuroscientists in Europe is large enough to match that of the neuroscientific community in North America. However, the degree of cohesiveness in the former is hampered by, among other things, the lack of a common language, the existence of geopolitical boundaries, and the dearth of pan-European funding ...
journal_title:Trends in neurosciences
pub_type: 杂志文章
doi:10.1016/0166-2236(94)90171-6
更新日期:1994-08-01 00:00:00
abstract::Synaptically released glutamate activates extrasynaptic receptors; such actions are controlled by glutamate uptake. Recent experimental findings show that there are many more glutamate transporters on the postsynaptic than presynaptic side of the vicinity of central synapses. This asymmetry favours activation of axona...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(02)02230-0
更新日期:2002-10-01 00:00:00
abstract::Previous studies have demonstrated that oligodendrocytes in the spinal cord and brainstem originate from restricted domains of ventral neuroepithelium under the influence of sonic hedgehog protein (SHH). However, the origin of oligodendrocytes in the telencephalon, the most anterior part of the CNS, has not been estab...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(02)02145-8
更新日期:2002-05-01 00:00:00
abstract::Trans-synaptic modulation of cortical ACh efflux is a useful approach for determining the functions of cortical ACh. Bilateral modulation of basal forebrain GABAergic transmission by benzodiazepine-receptor agonists and inverse agonists decreases and increases, respectively, activated cortical ACh efflux. The determin...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/0166-2236(94)90001-9
更新日期:1994-06-01 00:00:00
abstract::Inhibitory interneurons comprise a diverse subpopulation of cells that are critical to circuit function. How distinct inhibitory microcircuits control long-range projections remains poorly understood. A recent study by Lu and colleagues uncovered a unidirectional microcircuit of prefrontal chandelier cells that prefer...
journal_title:Trends in neurosciences
pub_type: 评论,杂志文章
doi:10.1016/j.tins.2017.09.005
更新日期:2017-11-01 00:00:00
abstract::The 'thrifty gene hypothesis' posits that evolution preferentially selects physiological mechanisms that optimize energy storage to increase survival under alternating conditions of abundance and scarcity of food. Recent experiments suggest that endocannabinoids - a class of lipid-derived mediators that activate canna...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2012.04.006
更新日期:2012-07-01 00:00:00
abstract::Classical receptive-field concepts have been used to explain local perceptual effects such as border contrast and Mach bands, but are not sufficient to explain global perceptual effects. Examples are the perception of illusory contours, area contrast, color constancy, depth planes, coherent motion and texture contrast...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/0166-2236(96)10038-2
更新日期:1996-10-01 00:00:00
abstract::Release probability (P) appears to be a major factor that influences the pattern of transmitter release. At cortical pyramidal axon inputs onto different classes of target cells, very different release patterns are observed, patterns that correlate with release probability. Simplistically, 'low P' synapses display fac...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(00)01580-0
更新日期:2000-07-01 00:00:00
abstract::To successfully interact with their environments, developing organisms need to correctly process sensory information and generate motor outputs appropriate to their size and structure. Patterned sensory experience has long been known to induce various forms of developmental plasticity that ultimately shape mature neur...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2010.01.003
更新日期:2010-04-01 00:00:00
abstract::Serotonin (5-HT) 5-HT(3) receptors are ligand-gated ion channels, which are generally thought to be involved in the presynaptic modulation of neurotransmitter release. However, analysis of published data reveals that most of the evidence for the alleged presynaptic role of 5-HT(3) receptors in modulating CNS neurotran...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(00)01662-3
更新日期:2000-12-01 00:00:00
abstract::Many behavioral responses are completed too quickly for the underlying sensory processes to rely on estimation of neural firing rates over extended time windows. Theoretically, first-spike times could underlie such rapid responses, but direct evidence has been lacking. Such evidence has now been uncovered in the human...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2004.10.010
更新日期:2005-01-01 00:00:00
abstract::Advances in gene discovery for neurodevelopmental disorders have identified SCN2A dysfunction as a leading cause of infantile seizures, autism spectrum disorder, and intellectual disability. SCN2A encodes the neuronal sodium channel NaV1.2. Functional assays demonstrate strong correlation between genotype and phenotyp...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2018.03.011
更新日期:2018-07-01 00:00:00