Abstract:
:Serotonin (5-HT) 5-HT(3) receptors are ligand-gated ion channels, which are generally thought to be involved in the presynaptic modulation of neurotransmitter release. However, analysis of published data reveals that most of the evidence for the alleged presynaptic role of 5-HT(3) receptors in modulating CNS neurotransmitter release is not compelling. Nevertheless, 5-HT(3) receptors are present in nerve terminals from some brain regions. The increased basic knowledge of the cellular physiology of central 5-HT(3) receptor ligand-gated ion channels provides opportunities for a detailed characterization of the specific presynaptic effects of 5-HT(3) receptors. Such reconsideration is required for the full appreciation of the functional role of 5-HT(3) receptors in the CNS.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
van Hooft JA,Vijverberg HPdoi
10.1016/s0166-2236(00)01662-3subject
Has Abstractpub_date
2000-12-01 00:00:00pages
605-10issue
12eissn
0166-2236issn
1878-108Xpii
S0166-2236(00)01662-3journal_volume
23pub_type
杂志文章,评审abstract::A century after the discovery of acetylcholine (ACh), we recognize both ACh receptors, transporters, and synthesizing and degrading enzymes and regulators of their expression as contributors to cognition, metabolism, and immunity. Recent discoveries indicate that pre- and post-transcriptional ACh signaling controllers...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2015.05.007
更新日期:2015-07-01 00:00:00
abstract::Most neurons are generated during development and are not replaced during adulthood, even if they are lost to injury or disease. However, it is firmly established that new neurons are generated in the dentate gyrus of the hippocampus of almost all adult mammals, including humans. Nevertheless, many questions remain re...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2015.07.005
更新日期:2015-09-01 00:00:00
abstract::This is a great age to participate in biological inquiry. Behavioral neuroscience offers a rich perspective for molecular biologists. However, behavioral analysis is not simply an assay. Whereas molecular biology has become a unique tool in the armamentarium of behavioral neuroscience, the powerful methodology of mole...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(00)01636-2
更新日期:2000-10-01 00:00:00
abstract::The complex issue of translating the planning of arm movements into muscle forces is discussed in relation to the recent discovery of structures in the spinal cord. These structures contain circuitry that, when activated, produce precisely balanced contractions in groups of muscles. These synergistic contractions gene...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/0166-2236(95)94494-p
更新日期:1995-10-01 00:00:00
abstract::The mechanisms underlying lesion formation in multiple sclerosis are unknown. The prevailing view is that macrophages are primary mediators of myelin destruction in the relapsing and remitting forms of this disease. However, recent findings have revealed widespread oligodendrocyte apoptosis in the absence of a clear c...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2005.01.006
更新日期:2005-04-01 00:00:00
abstract::How the brain becomes lateralized is poorly understood. By contrast, much is known about molecular cues that specify the left-right axis of the body, fashioning the asymmetric morphology and positioning of the visceral organs. In zebrafish, the Nodal signaling pathway functions in visceral asymmetry and also in the em...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/S0166-2236(03)00129-2
更新日期:2003-06-01 00:00:00
abstract::Imagine the decisions you might make while playing a simple game like 'matching pennies'. At each play, you and your opponent, say the mathematician John vonNeumann, each lay down a penny heads or tails up. If both pennies show the same side, vonNeumann wins, if not, you win. Before each play, you have the subjective ...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(00)01932-9
更新日期:2001-11-01 00:00:00
abstract::Striatal enriched tyrosine phosphatase (STEP) has recently been identified as a crucial player in the regulation of synaptic function. It is restricted to neurons within the CNS and acts by downregulating the activity of MAP kinases, the tyrosine kinase Fyn and NMDA receptors. By modulating these substrates, STEP acts...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2006.06.007
更新日期:2006-08-01 00:00:00
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journal_title:Trends in neurosciences
pub_type: 杂志文章
doi:10.1016/s0166-2236(00)01747-1
更新日期:2001-03-01 00:00:00
abstract::The molecular nature of the metabotropic GABA(B) receptor was for some time a mystery, however it was recently discovered that two related G-protein-coupled receptors have to heterodimerize to form the functional GABA(B) receptor at the cell surface. This review discusses the most recent findings in the rapidly expand...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(00)01815-4
更新日期:2001-05-01 00:00:00
abstract::Modern neuroscientific techniques that specifically manipulate and measure neuronal activity in behaving animals now allow bridging of the gap from the cellular to the behavioral level. However, in doing so, they also pose new challenges. Research using incompletely defined manipulations in a high-dimensional space wi...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2018.01.002
更新日期:2018-03-01 00:00:00
abstract::Brain dynamic changes associated with schizophrenia are largely equivocal, with interpretation complicated by many factors, such as the presence of therapeutic agents and the complex nature of the syndrome itself. Evidence for a brain-wide change in individual network oscillations, shared by all patients, is largely e...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2017.04.003
更新日期:2017-06-01 00:00:00
abstract::To understand the role of a gene in adult behavior, it is necessary to control its expression in four dimensions: space and time. Two recent papers describe implementation of different but related technologies that now provide this missing element in fly behavioral research. ...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2004.06.013
更新日期:2004-09-01 00:00:00
abstract::Cell replacement therapy has been proposed as a means to replace lost dopaminergic neurons in Parkinson's disease (PD). In most studies, the transplanted cells have been placed within the target site, the striatum, and not within the lesioned site, the substantia nigra, as the adult nigrostriatal pathway was thought t...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2011.01.003
更新日期:2011-03-01 00:00:00
abstract::The current dominant model of binaural sound localization proposes that the lateral position of a sound source is determined by the position of maximal activation within an array of binaural coincidence-detector neurons that are tuned to different interaural time differences (ITDs). The tuning of a neuron for an ITD i...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/S0166-2236(03)00140-1
更新日期:2003-07-01 00:00:00
abstract::Anatomical and functional studies of the prefrontal cortex (PFC) have identified multiple PFC subregions. We argue that the PFC is involved in cognitive functions exceeding the sum of specific functions attributed to its subregions. These can be revealed either by lesions of the whole PFC, or more specifically by sele...
journal_title:Trends in neurosciences
pub_type: 杂志文章
doi:10.1016/j.tins.2010.08.001
更新日期:2010-12-01 00:00:00
abstract::Two recent monkey studies demonstrate that feedforward processing in the visual system is reflected by activity in the 40-90Hz gamma band, whereas feedback is reflected by activity in the 5-18Hz alpha and beta band. These findings can be applied to interpret human electrophysiological activity in complex visual tasks....
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2015.02.006
更新日期:2015-04-01 00:00:00
abstract::Among the many calcium-binding proteins in the nervous system, parvalbumin, calbindin-D28K and calretinin are particularly striking in their abundance and in the specificity of their distribution. They can be found in different subsets of neurons in many brain regions. Although it is not yet known whether they play a ...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/0166-2236(92)90081-i
更新日期:1992-08-01 00:00:00
abstract::In mature rodents, whisker-related patterns are known to be present in three levels of the brain: the brainstem trigeminal nuclei, the ventrobasal thalamus and the somatosensory cortex. These patterns have been demonstrated using neuroanatomical tracing techniques, histological and histochemical staining methods and e...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(97)01217-4
更新日期:1998-06-01 00:00:00
abstract::There are pluripotent stem cells in the adult brain that might not be very different from those found in bone marrow. Recent and profound advances in the field of neuropoiesis, which often rely on insights from studies of hematopoiesis and in some instances use cross-paradigms with this field, have already revealed th...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(99)01416-2
更新日期:1999-08-01 00:00:00
abstract::During the past 30 years, research into developmental disorders has fragmented, emphasizing differences rather than commonalities. We propose that reunification might be achieved by using a "neural-systems" approach. Deficits in dyslexia are attributed to an intact declarative learning system combined with an impaired...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2007.02.003
更新日期:2007-04-01 00:00:00
abstract::Sensory representations are repeatedly transformed by neural computations that determine which of their attributes can be effectively processed at each stage. Whereas some early computations are common across multiple sensory systems, they can utilize dissimilar underlying mechanisms depending on the properties of eac...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2009.12.004
更新日期:2010-03-01 00:00:00
abstract::The human brain can be stimulated by a single intense magnetic pulse over the scalp. Currents induced within the cranium excite the motor cortex and cause limb muscles to contract. The discharge of single motor units, the firing of which is maintained by voluntary effort, can be modulated by magnetic stimuli. Peri-sti...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/0166-2236(91)90029-t
更新日期:1991-09-01 00:00:00
abstract::'Forward models' are increasingly recognized as a crucial explanatory concept in vertebrate motor control. The essential idea is that an important function implemented by nervous systems is prediction of the sensory consequences of action. This is often associated with higher cognitive capabilities; however, many of t...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2004.03.004
更新日期:2004-05-01 00:00:00
abstract::Central processing of olfactory information has been analyzed in the mushroom body of Drosophila by Ca(2+) imaging, extending such analysis of odor coding to the second relay of the olfactory system. Different odors, and different concentrations of a particular odor, yield distinct spatial patterns of activity. Mutati...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(00)01895-6
更新日期:2001-09-01 00:00:00
abstract::A defining feature of the vertebrate nervous system is the ensheathment of axons by myelin, a multilamellar membrane containing a small group of proteins and an abundance of the galactolipid galactocerebroside (GalC) and its sulfated derivative sulfatide. Several in vitro studies have suggested that these galactolipid...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(97)01178-8
更新日期:1998-03-01 00:00:00
abstract::The existence of an endogenous cannabinoid system was demonstrated conclusively with the discovery of endogenous brain constituents capable of activating the cannabinoid receptors functionally. These compounds are synthesized by neuronal cells and inactivated through re-uptake and enzymatic hydrolysis by both neurons ...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(98)01283-1
更新日期:1998-12-01 00:00:00
abstract::Presynaptic NMDA receptors (preNMDARs) play pivotal roles in excitatory neurotransmission and synaptic plasticity. They facilitate presynaptic neurotransmitter release and modulate mechanisms controlling synaptic maturation and plasticity during formative periods of brain development. There is an increasing understand...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2015.11.001
更新日期:2016-01-01 00:00:00
abstract::Although the mechanisms regulating the cerebral microcirculation during neural activity have been the subject of inquiry for a century or more, the mediators responsible for the changes in cerebral blood flow still remain to be clearly identified. The discovery that nitric oxide, a powerful cerebrovasodilator, is prod...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/0166-2236(93)90156-g
更新日期:1993-06-01 00:00:00
abstract::Relief from pain in humans is rewarding and pleasurable. Primary rewards, or reward-predictive cues, are encoded in brain reward/motivational circuits. While considerable advances have been made in our understanding of reward circuits underlying positive reinforcement, less is known about the circuits underlying the h...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2015.09.003
更新日期:2015-11-01 00:00:00