Abstract:
:Modern neuroscientific techniques that specifically manipulate and measure neuronal activity in behaving animals now allow bridging of the gap from the cellular to the behavioral level. However, in doing so, they also pose new challenges. Research using incompletely defined manipulations in a high-dimensional space without clear hypotheses is likely to suffer from multiple well-known conceptual and statistical problems. In this context it is essential to develop hypotheses with testable implications across levels. Here we propose that a focus on circuit motifs can help achieve this goal. Viewing neural structures as an assembly of circuit motif building blocks is not new. However, recent tool advances have made it possible to extensively map, specifically manipulate, and quantitatively investigate circuit motifs and thereby reexamine their relevance to brain function.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Braganza O,Beck Hdoi
10.1016/j.tins.2018.01.002subject
Has Abstractpub_date
2018-03-01 00:00:00pages
128-136issue
3eissn
0166-2236issn
1878-108Xpii
S0166-2236(18)30002-Xjournal_volume
41pub_type
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