Abstract：
:Aging is characterized by decrements in maximum function and accumulation of mitochondrial DNA mutations, which are best observed in organs such as the brain that contain post-mitotic cells. Oxygen radicals are increasingly considered responsible for part of these aging changes. Comparative studies of animals with different aging rates have shown that the rate of mitochondrial oxygen radical generation is directly related to the steady-state level of oxidative damage to mitochondrial DNA and is inversely correlated with maximum longevity in higher vertebrates. The degree of unsaturation of tissue fatty acids also correlates inversely with maximum longevity. These are the two known traits connecting oxidative stress with aging. Furthermore, caloric restriction, which decreases the rate of aging, proportionately decreases mitochondrial oxygen radical generation, especially at complex I. These findings are reviewed, highlighting the results obtained in the brain.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Barja Gdoi
10.1016/j.tins.2004.07.005subject
Has Abstractpub_date
2004-10-01 00:00:00pages
595-600issue
10eissn
0166-2236issn
1878-108Xpii
S0166-2236(04)00233-4journal_volume
27pub_type
杂志文章,评审abstract：:Inhibitory interneurons comprise a diverse subpopulation of cells that are critical to circuit function. How distinct inhibitory microcircuits control long-range projections remains poorly understood. A recent study by Lu and colleagues uncovered a unidirectional microcircuit of prefrontal chandelier cells that prefer...
journal_title：Trends in neurosciences
pub_type： 评论,杂志文章
doi：10.1016/j.tins.2017.09.005
更新日期：2017-11-01 00:00:00
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journal_title：Trends in neurosciences
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doi：10.1016/0166-2236(94)90055-8
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journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2019.10.001
更新日期：2019-12-01 00:00:00
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journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2007.05.004
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journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
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journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
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journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
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journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2010.04.004
更新日期：2010-09-01 00:00:00
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journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2005.12.002
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journal_title：Trends in neurosciences
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journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2014.05.005
更新日期：2014-08-01 00:00:00
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journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/s0166-2236(02)02145-8
更新日期：2002-05-01 00:00:00
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journal_title：Trends in neurosciences
pub_type： 杂志文章
doi：10.1016/j.tins.2015.09.002
更新日期：2015-11-01 00:00:00
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journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/s0166-2236(98)01315-0
更新日期：1998-09-01 00:00:00
abstract：:Chronic pain is sustained by central neuronal sensitization, with many similar characteristics irrespective of the type of injury incurred. Nevertheless, pain arising from nerve injury (neuropathic pain) is resistant to centrally acting analgesics, whereas inflammatory pain responds well. New research indicates that t...
journal_title：Trends in neurosciences
pub_type： 杂志文章
doi：10.1016/j.tins.2004.03.014
更新日期：2004-06-01 00:00:00
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journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/s0166-2236(97)01217-4
更新日期：1998-06-01 00:00:00
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journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/s0166-2236(02)02241-5
更新日期：2002-10-01 00:00:00
abstract：:The complex issue of translating the planning of arm movements into muscle forces is discussed in relation to the recent discovery of structures in the spinal cord. These structures contain circuitry that, when activated, produce precisely balanced contractions in groups of muscles. These synergistic contractions gene...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/0166-2236(95)94494-p
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abstract：:Trans-synaptic modulation of cortical ACh efflux is a useful approach for determining the functions of cortical ACh. Bilateral modulation of basal forebrain GABAergic transmission by benzodiazepine-receptor agonists and inverse agonists decreases and increases, respectively, activated cortical ACh efflux. The determin...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/0166-2236(94)90001-9
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journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2006.06.014
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journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/0166-2236(90)90106-k
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journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2005.01.006
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journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
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abstract：:Sleep can facilitate memory formation, but its role in cortical plasticity is poorly understood. A recent study found that sleep, following monocular deprivation (MD), facilitated cortical changes in ocular dominance. The magnitude of plasticity was similar to that observed after continued MD, and larger than that see...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/s0166-2236(00)02005-1
更新日期：2002-01-01 00:00:00
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journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/s0166-2236(98)01225-9
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abstract：:The discovery of genetic forms of Parkinson's disease (PD) has highlighted the importance of the autophagy/lysosomal and mitochondrial/oxidative stress pathways in disease pathogenesis. However, recently identified PD-linked genes, including DNAJC6 (auxilin), SYNJ1 (synaptojanin 1), and the PD risk gene SH3GL2 (endoph...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2018.11.001
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abstract：:Recent years have seen a flourishing literature on detection of circulating autoantibodies against neurotransmitter receptors in patients with neuropsychiatric disorders. These studies have generated hope for a better understanding of the underlying molecular dysfunctions and for appropriate therapeutic strategies. Ho...
journal_title：Trends in neurosciences
pub_type： 杂志文章
doi：10.1016/j.tins.2018.05.002
更新日期：2018-08-01 00:00:00
abstract：:The majority of Alzheimer's disease is inherited in a complex manner involving environmental factors and several genes. One of these genes is Apolipoprotein E where the polymorphic allele (APOE epsilon 4) has been robustly shown to modify risk and the course of Alzheimer's disease. The epsilon 4 allele however, only a...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/s0166-2236(00)01912-3
更新日期：2001-10-01 00:00:00
abstract：:Huntington's disease (HD) is a fatal, inherited neurodegenerative disorder that gradually robs affected individuals of memory, cognitive skills and normal movements. Although research has identified a single faulty gene, the huntingtin gene, as the cause of the disease, a cure remains elusive. Strong evidence indicate...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2008.09.004
更新日期：2008-12-01 00:00:00
abstract：:Currently available antibodies to the P2X(7) receptor are unreliable determinants of neuronal P2X(7) immunoreactivity, owing to staining of a "P2X(7)-like" protein that is not eliminated by legitimate P2X(7) gene-knockout approaches. Despite this, compelling electrophysiological and pharmacological data strongly suppo...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2006.03.003
更新日期：2006-05-01 00:00:00
