Abstract:
:Presynaptic NMDA receptors (preNMDARs) play pivotal roles in excitatory neurotransmission and synaptic plasticity. They facilitate presynaptic neurotransmitter release and modulate mechanisms controlling synaptic maturation and plasticity during formative periods of brain development. There is an increasing understanding of the roles of preNMDARs in experience-dependent synaptic and circuit-specific computation. In this review we summarize the latest understanding of compartment-specific expression and function of preNMDARs, and how they contribute to synapse-specific and circuit-level information processing.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Banerjee A,Larsen RS,Philpot BD,Paulsen Odoi
10.1016/j.tins.2015.11.001subject
Has Abstractpub_date
2016-01-01 00:00:00pages
26-39issue
1eissn
0166-2236issn
1878-108Xpii
S0166-2236(15)00247-7journal_volume
39pub_type
杂志文章,评审abstract::A variety of fatty acids regulate the activity of specific ion channels by mechanisms not involving the enzymatic pathways that convert arachidonic acid to oxygenated metabolites. Furthermore, these actions of fatty acids occur in patches of membrane excised from the cell and are not mediated by cellular signal transd...
journal_title:Trends in neurosciences
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journal_title:Trends in neurosciences
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pub_type: 杂志文章,评审
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journal_title:Trends in neurosciences
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journal_title:Trends in neurosciences
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