Abstract:
:Compromise of the ubiquitin-proteasome system (UPS) is a potential basis for multiple physiological abnormalities and pathologies in the CNS. This could be because reduced protein turnover leads to bulk intracellular protein accumulation. However, conditions associated with compromised UPS function are also associated with impairments in protein synthesis, and impairment of UPS function is sufficient to inhibit protein synthesis. These data suggest that the toxicity of UPS inhibition need not depend on gross intracellular protein accumulation, and indicate the potential for crosstalk between the UPS and protein-synthesis pathways. In this review, we discuss evidence for interplay between the UPS and protein-synthesis machinery, and outline the implications of this crosstalk for physiological and pathological processes in the CNS.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Ding Q,Cecarini V,Keller JNdoi
10.1016/j.tins.2006.11.003subject
Has Abstractpub_date
2007-01-01 00:00:00pages
31-6issue
1eissn
0166-2236issn
1878-108Xpii
S0166-2236(06)00266-9journal_volume
30pub_type
杂志文章,评审abstract::The production by the pyridine MPTP of a parkinsonian syndrome strikingly similar to the 'idiopathic' disorder, and the paucity of evidence supporting a hereditary or infectious etiology for Parkinson's disease (PD), have stimulated a search for environmental chemicals resembling MPTP that might cause PD. In support o...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/0166-2236(89)90135-5
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abstract::How the brain becomes lateralized is poorly understood. By contrast, much is known about molecular cues that specify the left-right axis of the body, fashioning the asymmetric morphology and positioning of the visceral organs. In zebrafish, the Nodal signaling pathway functions in visceral asymmetry and also in the em...
journal_title:Trends in neurosciences
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doi:10.1016/S0166-2236(03)00129-2
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abstract::For organs innervated by the autonomic nervous system, it is generally held that neuroeffector transmission is achieved by varicosities releasing transmitters some distance from the membranes of target cells. Transmitters are thought to diffuse through the extracellular space and interact with post-junctional receptor...
journal_title:Trends in neurosciences
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doi:10.1016/0166-2236(92)90024-3
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journal_title:Trends in neurosciences
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(99)01447-2
更新日期:1999-11-01 00:00:00
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
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journal_title:Trends in neurosciences
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journal_title:Trends in neurosciences
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journal_title:Trends in neurosciences
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journal_title:Trends in neurosciences
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journal_title:Trends in neurosciences
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更新日期:1996-02-01 00:00:00
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2018.11.001
更新日期:2019-02-01 00:00:00
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
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journal_title:Trends in neurosciences
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doi:10.1016/0166-2236(93)90079-2
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journal_title:Trends in neurosciences
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journal_title:Trends in neurosciences
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更新日期:2001-05-01 00:00:00
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journal_title:Trends in neurosciences
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doi:10.1016/j.tins.2007.11.006
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journal_title:Trends in neurosciences
pub_type: 杂志文章
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journal_title:Trends in neurosciences
pub_type: 评论,杂志文章
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journal_title:Trends in neurosciences
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2009.12.002
更新日期:2010-03-01 00:00:00
abstract::It might appear curious to read about yeast, slime molds and protozoa in a journal dedicated to neuroscience. However, despite their distinct lack of synapses, eukaryotic microorganisms hold a wealth of information relevant to the signal-transduction pathways that underly activity in neuronal receptor cells, particula...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
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abstract::Mitochondrial dysfunction has been implicated in the pathogenesis of almost all neurological diseases, including Alzheimer's disease (AD). Historically, a primary focus in this context has been the link between mitochondrial dynamics and amyloid β toxicity. Recent evidence suggests that dysregulation of mitochondrial ...
journal_title:Trends in neurosciences
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更新日期:2021-02-01 00:00:00
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
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更新日期:2009-09-01 00:00:00
abstract::Imagine the decisions you might make while playing a simple game like 'matching pennies'. At each play, you and your opponent, say the mathematician John vonNeumann, each lay down a penny heads or tails up. If both pennies show the same side, vonNeumann wins, if not, you win. Before each play, you have the subjective ...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
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更新日期:2001-11-01 00:00:00
abstract::The transition from short- to long-term memory requires lasting modulations of synaptic connectivity. In a variety of species and learning tasks, enhanced synthesis of glycoprotein cell-adhesion molecules (CAMs), such as neural CAM (NCAM) and Ll, 5-8 h post-training is a necessary step in this process. If the training...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
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更新日期:1995-11-01 00:00:00