Abstract:
:Schizophrenia (SZ) is primarily an adult psychiatric disorder in which disturbances caused by susceptibility genes and environmental insults during early neurodevelopment initiate neurophysiological changes over a long time course, culminating in the onset of full-blown disease nearly two decades later. Aberrant postnatal brain maturation is an essential mechanism underlying the disease. Currently, symptoms of SZ are treated with anti-psychotic medications that have variable efficacy and severe side effects. There has been much interest in the prodromal phase and the possibility of preventing SZ by interfering with the aberrant postnatal brain maturation associated with this disorder. Thus, it is crucial to understand the mechanisms that underlie the long-term progression to full disease manifestation to identify the best targets and approaches towards this goal. We believe that studies of certain SZ genetic susceptibility factors with neurodevelopmental implications will be key tools in this task. Accumulating evidence suggests that neuregulin-1 (NRG1) and disrupted-in-schizophrenia-1 (DISC1) are probably functionally convergent and play key roles in brain development. We provide an update on the role of these emerging concepts in understanding the complex time course of SZ from early neurodevelopmental disturbances to later onset and suggest ways of testing these in the future.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Jaaro-Peled H,Hayashi-Takagi A,Seshadri S,Kamiya A,Brandon NJ,Sawa Adoi
10.1016/j.tins.2009.05.007subject
Has Abstractpub_date
2009-09-01 00:00:00pages
485-95issue
9eissn
0166-2236issn
1878-108Xpii
S0166-2236(09)00108-8journal_volume
32pub_type
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