Abstract:
:Neurons are dynamic cells that respond and adapt to stimuli throughout their long postmitotic lives. The structural and functional plasticity of neurons requires the regulated transcription of new gene products, and dysregulation of transcription in either the developing or adult brain impairs cognition. We discuss how mechanisms of chromatin regulation help to orchestrate the transcriptional programs that underlie the maturation of developing neurons and the plasticity of adult neurons. We review how chromatin regulation acts locally to modulate the expression of specific genes and more broadly to coordinate gene expression programs during transitions between cellular states. These data highlight the importance of epigenetic transcriptional mechanisms in postmitotic neurons. We suggest areas where emerging methods may advance understanding in the future.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Gallegos DA,Chan U,Chen LF,West AEdoi
10.1016/j.tins.2018.02.009subject
Has Abstractpub_date
2018-05-01 00:00:00pages
311-324issue
5eissn
0166-2236issn
1878-108Xpii
S0166-2236(18)30055-9journal_volume
41pub_type
杂志文章,评审abstract::The discovery of genetic forms of Parkinson's disease (PD) has highlighted the importance of the autophagy/lysosomal and mitochondrial/oxidative stress pathways in disease pathogenesis. However, recently identified PD-linked genes, including DNAJC6 (auxilin), SYNJ1 (synaptojanin 1), and the PD risk gene SH3GL2 (endoph...
journal_title:Trends in neurosciences
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doi:10.1016/j.tins.2018.11.001
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abstract::Unlike most mammalian species, the prairie vole is highly affiliative, forms enduring social bonds between mates and displays biparental behavior. Over two decades of research on this species has enhanced our understanding of the neurobiological basis not only of monogamy, social attachment and nurturing behaviors but...
journal_title:Trends in neurosciences
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journal_title:Trends in neurosciences
pub_type: 历史文章,杂志文章,评审
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2012.08.006
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(00)02035-x
更新日期:2002-03-01 00:00:00
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journal_title:Trends in neurosciences
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doi:10.1016/j.tins.2018.08.011
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journal_title:Trends in neurosciences
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2011.12.002
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journal_title:Trends in neurosciences
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
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更新日期:2000-08-01 00:00:00
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/S0166-2236(96)40005-4
更新日期:1997-01-01 00:00:00
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2018.01.002
更新日期:2018-03-01 00:00:00
abstract::Oxytocin and vasopressin are regulators of anxiety, stress-coping, and sociality. They are released within hypothalamic and limbic areas from dendrites, axons, and perikarya independently of, or coordinated with, secretion from neurohypophysial terminals. Central oxytocin exerts anxiolytic and antidepressive effects, ...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2012.08.004
更新日期:2012-11-01 00:00:00
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2010.11.001
更新日期:2011-02-01 00:00:00
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/S0166-2236(03)00212-1
更新日期:2003-09-01 00:00:00
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/0166-2236(95)93907-f
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journal_title:Trends in neurosciences
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
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journal_title:Trends in neurosciences
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journal_title:Trends in neurosciences
pub_type: 杂志文章
doi:10.1016/s0166-2236(99)01520-9
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
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更新日期:2002-05-01 00:00:00
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
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更新日期:1997-08-01 00:00:00
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/0166-2236(93)90043-l
更新日期:1993-01-01 00:00:00
abstract::The nervous system is made up of many specific types of neuron intricately intertwined to form complex networks. Identifying and defining the characteristic features of the many different neuronal types is essential for achieving a cellular understanding of complex activity from perception to cognition. So far, cortic...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2003.08.002
更新日期:2003-10-01 00:00:00
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
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更新日期:2002-08-01 00:00:00
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(97)01139-9
更新日期:1997-12-01 00:00:00
abstract::Brain dynamic changes associated with schizophrenia are largely equivocal, with interpretation complicated by many factors, such as the presence of therapeutic agents and the complex nature of the syndrome itself. Evidence for a brain-wide change in individual network oscillations, shared by all patients, is largely e...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2017.04.003
更新日期:2017-06-01 00:00:00
abstract::Exocytosis in neurones and neuroendocrine cells is triggered by an increase in the cytosolic concentration of Ca2+, and is followed by endocytotic membrane retrieval. Electrophysiological studies have characterized the nature of the Ca2+ signal that is required for exocytosis, and have defined the Ca(2+)-dependent ste...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/0166-2236(95)93900-i
更新日期:1995-04-01 00:00:00