The role of anchoring protein RACK1 in PKC activation in the ageing rat brain.

abstract：:Aging is characterized by decrements in maximum function and accumulation of mitochondrial DNA mutations, which are best observed in organs such as the brain that contain post-mitotic cells. Oxygen radicals are increasingly considered responsible for part of these aging changes. Comparative studies of animals with dif...

journal_title：Trends in neurosciences

authors： Barja G

更新日期：2004-10-01 00:00:00

abstract：:A genetic analysis of mammalian neuronal physiology might now be possible due to the development of defective herpes simplex virus vectors, which allow gene transfer directly into mature neurons, in culture or in the adult brain. Genetically altered proteins that play critical roles in neuronal physiology, including t...

journal_title：Trends in neurosciences

authors： Geller AI,During MJ,Neve RL

更新日期：1991-10-01 00:00:00

abstract：:A defining feature of the vertebrate nervous system is the ensheathment of axons by myelin, a multilamellar membrane containing a small group of proteins and an abundance of the galactolipid galactocerebroside (GalC) and its sulfated derivative sulfatide. Several in vitro studies have suggested that these galactolipid...

journal_title：Trends in neurosciences

authors： Coetzee T,Suzuki K,Popko B

更新日期：1998-03-01 00:00:00

abstract：:CNS myelin inhibits axonal outgrowth in vitro and is one of several obstacles to functional recovery following spinal cord injury. Central to our current understanding of myelin-mediated inhibition are the membrane protein Nogo and the Nogo-66 receptor (NgR). New findings implicate NgR as a point of convergence in sig...

journal_title：Trends in neurosciences

authors： McGee AW,Strittmatter SM

更新日期：2003-04-01 00:00:00

abstract：:Local signaling events at synapses or axon terminals must be communicated to the nucleus to elicit transcriptional responses. The lengths of neuronal processes pose a significant challenge for such intracellular communication. This challenge is met by mechanisms ranging from rapid signals encoded in calcium waves to s...

journal_title：Trends in neurosciences

authors： Panayotis N,Karpova A,Kreutz MR,Fainzilber M

更新日期：2015-02-01 00:00:00

abstract：:Active feedback mechanisms in the ears of mammals amplify and tune the auditory response to sound stimuli, allowing these organisms to enjoy both exquisite sensitivity and sharp frequency selectivity. A requisite component of this feedback pathway has recently been identified. Targeted deletion of pres, the gene that ...

journal_title：Trends in neurosciences

authors： Géléoc GS,Holt JR

更新日期：2003-03-01 00:00:00

abstract：:Both ageing and chronic stress are associated with altered brain plasticity, dysregulation of the immune system, and an increased risk of developing brain disorders; all of which have consequences for cognitive and emotional processing. Here we examine the similarities between behavioural changes during ageing and str...

journal_title：Trends in neurosciences

authors： Prenderville JA,Kennedy PJ,Dinan TG,Cryan JF

更新日期：2015-01-01 00:00:00

abstract：:Advances in understanding the biology of neurotrophic factors and their signaling pathways have provided important insights into the normal growth, differentiation and maintenance of neurons. Stimulated by neuropathological observations and genetic discoveries, studies in cell and animal models of neurodegenerative di...

journal_title：Trends in neurosciences

authors： Salehi A,Delcroix JD,Mobley WC

更新日期：2003-02-01 00:00:00

abstract：:Current emphasis on odorant physiochemical features as the basis for perception largely ignores the synthetic and experience-dependent nature of olfaction. Olfaction is synthetic, as mammals have only limited ability to identify elements within even simple odor mixtures. Furthermore, olfaction is experience-bound, as ...

journal_title：Trends in neurosciences

authors： Wilson DA,Stevenson RJ

更新日期：2003-05-01 00:00:00

abstract：:The hereditary ataxias are a group of inherited neurodegenerative disorders characterized by progressive ataxia that results from degeneration of the cerebellum and its afferent and efferent connections. Recent molecular research has led not only to the discovery of a number of causative mutations, but also shed light...

journal_title：Trends in neurosciences

authors： Klockgether T,Evert B

更新日期：1998-09-01 00:00:00

abstract：:The birth of new neurons in the walls of the adult brain lateral ventricles has captured the attention of many neuroscientists for over 2 decades, yielding key insights into the identity and regulation of neural stem cells (NSCs). In the adult ventricular-subventricular zone (V-SVZ), NSCs are a specialized form of ast...

journal_title：Trends in neurosciences

authors： Lim DA,Alvarez-Buylla A

更新日期：2014-10-01 00:00:00

abstract：:Mesolimbic dopaminergic neurons are thought to serve as a final common neural pathway for mediating reinforcement processes. However, several recent findings have challenged the view that mesolimbic dopamine has a crucial role in the maintenance of reinforcement processes, or the subjective rewarding actions of natura...

journal_title：Trends in neurosciences

authors： Spanagel R,Weiss F

更新日期：1999-11-01 00:00:00

abstract：:The human brain can be stimulated by a single intense magnetic pulse over the scalp. Currents induced within the cranium excite the motor cortex and cause limb muscles to contract. The discharge of single motor units, the firing of which is maintained by voluntary effort, can be modulated by magnetic stimuli. Peri-sti...

journal_title：Trends in neurosciences

authors： Mills KR

更新日期：1991-09-01 00:00:00

abstract：:Strong evidence has been provided that ATP can act as a transmitter not only in smooth muscle but also in peripheral ganglia and in brain. The cloning and molecular identification of two putative ATP receptors supports the previously established pharmacological receptor classifications. This review places into perspec...

journal_title：Trends in neurosciences

authors： Zimmermann H

更新日期：1994-10-01 00:00:00

abstract：:'Forward models' are increasingly recognized as a crucial explanatory concept in vertebrate motor control. The essential idea is that an important function implemented by nervous systems is prediction of the sensory consequences of action. This is often associated with higher cognitive capabilities; however, many of t...

journal_title：Trends in neurosciences

authors： Webb B

更新日期：2004-05-01 00:00:00

abstract：:The orexins (or hypocretins) are neuropeptide transmitters made exclusively in hypothalamic neurons that have extensive CNS projections. Previous studies reported that this system is most strongly associated with feeding, arousal and the maintenance of waking. We review here recent studies that reveal a novel and impo...

journal_title：Trends in neurosciences

authors： Harris GC,Aston-Jones G

更新日期：2006-10-01 00:00:00

abstract：:Classical receptive-field concepts have been used to explain local perceptual effects such as border contrast and Mach bands, but are not sufficient to explain global perceptual effects. Examples are the perception of illusory contours, area contrast, color constancy, depth planes, coherent motion and texture contrast...

journal_title：Trends in neurosciences

authors： Spillmann L,Werner JS

更新日期：1996-10-01 00:00:00

abstract：:Implanted neural probes are among the most important techniques in both fundamental and clinical neuroscience. Despite great successes and promise, neural electrodes are technically limited by their scalability. A recent study by Obaid et al. demonstrated an innovative way to greatly scale up the channel count and den...

journal_title：Trends in neurosciences

authors： Lycke R,Sun L,Luan L,Xie C

更新日期：2020-05-01 00:00:00

abstract：:The vertebrate neuromuscular junction (NMJ), a peripheral synapse formed between motoneuron and skeletal muscle, is characterized by a protracted postnatal period of maturation and life-long maintenance. In neuromuscular disorders such as congenital myasthenic syndromes (CMSs), disruptions of NMJ maturation and/or mai...

journal_title：Trends in neurosciences

authors： Shi L,Fu AK,Ip NY

更新日期：2012-07-01 00:00:00

abstract：:Aging is the most important risk factor for common neurodegenerative disorders such as Parkinson's and Alzheimer's diseases. Aging in the central nervous system has been associated with elevated mutation load in mitochondrial DNA, defects in mitochondrial respiration and increased oxidative damage. These observations ...

journal_title：Trends in neurosciences

authors： Fukui H,Moraes CT

更新日期：2008-05-01 00:00:00

abstract：:How the brain becomes lateralized is poorly understood. By contrast, much is known about molecular cues that specify the left-right axis of the body, fashioning the asymmetric morphology and positioning of the visceral organs. In zebrafish, the Nodal signaling pathway functions in visceral asymmetry and also in the em...

journal_title：Trends in neurosciences

authors： Halpern ME,Liang JO,Gamse JT

更新日期：2003-06-01 00:00:00

abstract：:Antisocial aggression is a widespread and expensive social problem. Although aggressive behaviors and temperament are highly heritable, clinical and trait associations for the most promising candidate gene for aggression, MAOA, have been largely inconsistent. We suggest that limitations inherent to that approach might...

journal_title：Trends in neurosciences

authors： Buckholtz JW,Meyer-Lindenberg A

更新日期：2008-03-01 00:00:00

abstract：:Korsakoff's disease is an amnesic syndrome associated with midline diencephalic and brain stem pathology. A number of neurochemical systems course through or near the loci of brain lesions found postmortem in Korsakoff patients, which has stimulated studies to learn whether these systems are implicated in amnesia. Dat...

journal_title：Trends in neurosciences

authors： McEntee WJ,Mair RG

更新日期：1990-08-01 00:00:00

abstract：:Cell replacement therapy has been proposed as a means to replace lost dopaminergic neurons in Parkinson's disease (PD). In most studies, the transplanted cells have been placed within the target site, the striatum, and not within the lesioned site, the substantia nigra, as the adult nigrostriatal pathway was thought t...

journal_title：Trends in neurosciences

authors： Gaillard A,Jaber M

更新日期：2011-03-01 00:00:00

abstract：:It is now clear that cytokines traditionally viewed as immune modulators participate in inflammatory responses within the adult nervous system. However, in the developing nervous system hematolymphopoietic cytokines also play a role unrelated to neural-immune interactions. Instead, many of these factors subserve prima...

journal_title：Trends in neurosciences

authors： Mehler MF,Kessler JA

更新日期：1997-08-01 00:00:00

abstract：:Changes in the actin cytoskeleton are a primary mechanism mediating the morphological and functional plasticity that underlies learning and memory. The synaptic Ras homologous (Rho) guanine nucleotide exchange factors (GEFs) Kalirin and Trio have emerged as central regulators of actin dynamics at the synapse. The incr...

journal_title：Trends in neurosciences

authors： Paskus JD,Herring BE,Roche KW

更新日期：2020-07-01 00:00:00

abstract：:Life span is determined by both environmental and genetic influences. The importance of genes is illustrated by the fact that single gene mutations extend life span in nematodes, fruit flies and mice. Recent reports reveal that the life span of Caenorhabditis elegans is controlled by insulin-like signals from the nerv...

journal_title：Trends in neurosciences

authors： Wolkow CA

更新日期：2002-04-01 00:00:00

abstract：:Axonal transport is critical for neuronal homeostasis and relies on motor complexes bound to cargoes via specific adaptors. However, the mechanisms responsible for the spatiotemporal regulation of axonal transport are not completely understood. A recent study by Liao et al. contributes to filling this gap by reporting...

journal_title：Trends in neurosciences

authors： Fratta P,Birsa N,Tosolini AP,Schiavo G

更新日期：2020-01-01 00:00:00

abstract：:As we learn more about the functional expression of nicotinic receptors in specific brain regions such as the hippocampus, intriguing interactions are being uncovered at the cellular and circuit levels. Recent work from John Dani's laboratory provides important insights into how nicotinic receptors can modify hippocam...

journal_title：Trends in neurosciences

authors： McGehee DS

更新日期：2002-04-01 00:00:00

abstract：:It is well established that some excitatory nerve terminals have high concentrations of Zn(2+) in their synaptic vesicles. For some time, it has been believed that synaptic Zn(2+) is released during neurotransmission and acts as a neuromodulator. Fluorescent Zn(2+) indicators that do not penetrate membranes offer the ...

journal_title：Trends in neurosciences

authors： Kay AR

更新日期：2006-04-01 00:00:00