Kalirin and Trio: RhoGEFs in Synaptic Transmission, Plasticity, and Complex Brain Disorders.

Abstract:

:Changes in the actin cytoskeleton are a primary mechanism mediating the morphological and functional plasticity that underlies learning and memory. The synaptic Ras homologous (Rho) guanine nucleotide exchange factors (GEFs) Kalirin and Trio have emerged as central regulators of actin dynamics at the synapse. The increased attention surrounding Kalirin and Trio stems from the growing evidence for their roles in the etiology of a wide range of neurodevelopmental and neurodegenerative disorders. In this Review, we discuss recent findings revealing the unique and diverse functions of these paralog proteins in neurodevelopment, excitatory synaptic transmission, and plasticity. We additionally survey the growing literature implicating these proteins in various neurological disorders.

journal_name

Trends Neurosci

journal_title

Trends in neurosciences

authors

Paskus JD,Herring BE,Roche KW

doi

10.1016/j.tins.2020.05.002

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

505-518

issue

7

eissn

0166-2236

issn

1878-108X

pii

S0166-2236(20)30104-1

journal_volume

43

pub_type

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