Abstract:
:Advances in understanding the biology of neurotrophic factors and their signaling pathways have provided important insights into the normal growth, differentiation and maintenance of neurons. Stimulated by neuropathological observations and genetic discoveries, studies in cell and animal models of neurodegenerative disorders have begun to clarify pathogenetic mechanisms. We examine the intersection of these research themes and identify several potential mechanisms for linking failed neurotrophic factor signaling to neurodegeneration. Studies of nerve growth factor signaling in a mouse model of Down syndrome encourage the views that neuronal dysfunction and atrophy might be linked to failed neurotrophic support and that additional studies focused on this possibility would enhance our understanding of the mechanisms of neurodegenerative disorders and their treatment.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Salehi A,Delcroix JD,Mobley WCdoi
10.1016/S0166-2236(02)00038-3subject
Has Abstractpub_date
2003-02-01 00:00:00pages
73-80issue
2eissn
0166-2236issn
1878-108Xpii
S0166-2236(02)00038-3journal_volume
26pub_type
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