Abstract:
:Cell replacement therapy has been proposed as a means to replace lost dopaminergic neurons in Parkinson's disease (PD). In most studies, the transplanted cells have been placed within the target site, the striatum, and not within the lesioned site, the substantia nigra, as the adult nigrostriatal pathway was thought to constitute a non-permissive environment for long distance axonal outgrowth of transplanted neuroblasts. Here, we discuss recent findings showing that intranigral transplanted dopaminergic neuroblasts can form axonal projections to the striatum, resulting in increased striatal dopamine levels and ameliorating behavioral deficits in animal models of PD. Such findings have raised new hopes and opened new avenues for cell replacement therapy in patients with PD.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Gaillard A,Jaber Mdoi
10.1016/j.tins.2011.01.003subject
Has Abstractpub_date
2011-03-01 00:00:00pages
124-33issue
3eissn
0166-2236issn
1878-108Xpii
S0166-2236(11)00004-Xjournal_volume
34pub_type
杂志文章,评审abstract::Activation of the complement system has been reported in a variety of inflammatory diseases and neurodegenerative processes of the CNS. Recent evidence indicates that complement proteins and receptors are synthesized on or by glial cells and, surprisingly, neurons. Among these proteins are the receptors for the chemot...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(98)01390-3
更新日期:1999-09-01 00:00:00
abstract::Progress in migraine research has been rapid in recent years, from both the basic science and the clinical perspectives. A new internationally accepted headache classification with operational diagnostic criteria was published in 1988, eliminating much diagnostic uncertainty. More than a decade of study of regional ce...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/0166-2236(91)90171-p
更新日期:1991-01-01 00:00:00
abstract::Rhythmic motor activity requires coordination of different muscles or muscle groups so that they are all active with the same cycle duration and appropriate phase relationships. The neural mechanisms for such phase coupling in vertebrate locomotion are not known. Swimming in the lamprey is accomplished by the generati...
journal_title:Trends in neurosciences
pub_type: 杂志文章
doi:10.1016/0166-2236(92)90006-t
更新日期:1992-11-01 00:00:00
abstract::Among the many calcium-binding proteins in the nervous system, parvalbumin, calbindin-D28K and calretinin are particularly striking in their abundance and in the specificity of their distribution. They can be found in different subsets of neurons in many brain regions. Although it is not yet known whether they play a ...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/0166-2236(92)90081-i
更新日期:1992-08-01 00:00:00
abstract::Recent progress in cognitive neuroscience highlights the involvement of the prefrontal cortex (PFC) in social cognition. Accumulating evidence demonstrates that representations within the lateral PFC enable people to coordinate their thoughts and actions with their intentions to support goal-directed social behavior. ...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2009.09.001
更新日期:2009-12-01 00:00:00
abstract::In monkeys, the rostral part of ventral premotor cortex (area F5) contains neurons that discharge, both when the monkey grasps or manipulates objects and when it observes the experimenter making similar actions. These neurons (mirror neurons) appear to represent a system that matches observed events to similar, intern...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(98)01260-0
更新日期:1998-05-01 00:00:00
abstract::Glia are the most abundant cell type in the mammalian nervous system and they have vital roles in neural development, function and health. However our understanding of the biology of glia is in its infancy. How do glia develop and interact with neurons? How diverse are glial populations? What are the primary functions...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2005.12.002
更新日期:2006-02-01 00:00:00
abstract::Advances in gene discovery for neurodevelopmental disorders have identified SCN2A dysfunction as a leading cause of infantile seizures, autism spectrum disorder, and intellectual disability. SCN2A encodes the neuronal sodium channel NaV1.2. Functional assays demonstrate strong correlation between genotype and phenotyp...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2018.03.011
更新日期:2018-07-01 00:00:00
abstract::Hebbian synaptic learning requires co-activation of presynaptic and postsynaptic neurons. However, under some conditions, information regarding the postsynaptic action potential, carried by backpropagating action potentials, can be strongly degraded before it reaches the distal exhibit Hebbian long-term potentiation (...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2003.12.004
更新日期:2004-02-01 00:00:00
abstract::Serotonin (5-HT) 5-HT(3) receptors are ligand-gated ion channels, which are generally thought to be involved in the presynaptic modulation of neurotransmitter release. However, analysis of published data reveals that most of the evidence for the alleged presynaptic role of 5-HT(3) receptors in modulating CNS neurotran...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(00)01662-3
更新日期:2000-12-01 00:00:00
abstract::This is a great age to participate in biological inquiry. Behavioral neuroscience offers a rich perspective for molecular biologists. However, behavioral analysis is not simply an assay. Whereas molecular biology has become a unique tool in the armamentarium of behavioral neuroscience, the powerful methodology of mole...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(00)01636-2
更新日期:2000-10-01 00:00:00
abstract::The hippocampus is thought to automatically encode all experience, yet the vast majority of our experiences are not remembered later. Although psychological theories have postulated the existence of decay processes for declarative memory, the corresponding neurobiological mechanisms are unknown. Here we develop the hy...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2013.05.002
更新日期:2013-09-01 00:00:00
abstract::Chronic pain is sustained by central neuronal sensitization, with many similar characteristics irrespective of the type of injury incurred. Nevertheless, pain arising from nerve injury (neuropathic pain) is resistant to centrally acting analgesics, whereas inflammatory pain responds well. New research indicates that t...
journal_title:Trends in neurosciences
pub_type: 杂志文章
doi:10.1016/j.tins.2004.03.014
更新日期:2004-06-01 00:00:00
abstract::More often than not, action potentials fail to trigger neurotransmitter release. And even when neurotransmitter is released, the resulting change in synaptic conductance is highly variable. Given the energetic cost of generating and propagating action potentials, and the importance of information transmission across s...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2020.03.009
更新日期:2020-06-01 00:00:00
abstract::The molecular nature of the metabotropic GABA(B) receptor was for some time a mystery, however it was recently discovered that two related G-protein-coupled receptors have to heterodimerize to form the functional GABA(B) receptor at the cell surface. This review discusses the most recent findings in the rapidly expand...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(00)01815-4
更新日期:2001-05-01 00:00:00
abstract::Nearly 30 years ago, a debate over two disparate models of synaptic vesicle retrieval arose. Subsequent investigations to determine which model was correct proved inconclusive and served only to further the debate. However, recent evidence has begun to suggest that both models are valid and relevant in understanding t...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(00)01769-0
更新日期:2001-04-01 00:00:00
abstract::Multiple sclerosis (MS), an incurable but manageable disorder, is characterized by chronic inflammatory demyelination and neurodegeneration in the central nervous system. Although the primary cause of this often devastating disease remains elusive, major therapeutic advances have occurred during the past two decades. ...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2009.12.002
更新日期:2010-03-01 00:00:00
abstract::No therapy exists to slow down or prevent Parkinson's disease (PD), a debilitating neurodegenerative disorder. Neurotrophic factors (NTFs) emerged as promising disease-modifying agents in PD and are currently under clinical development. We argue that efforts in three research areas must converge to harness the full th...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2010.11.001
更新日期:2011-02-01 00:00:00
abstract::The precise modulation of regional cerebral blood flow during neural activation is important for matching local energetic demand and supply and clearing brain metabolites. Here we discuss advances facilitated by high-resolution optical in vivo imaging techniques that for the first time have provided direct visualizati...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2019.05.009
更新日期:2019-08-01 00:00:00
abstract::The orexins (or hypocretins) are neuropeptide transmitters made exclusively in hypothalamic neurons that have extensive CNS projections. Previous studies reported that this system is most strongly associated with feeding, arousal and the maintenance of waking. We review here recent studies that reveal a novel and impo...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2006.08.002
更新日期:2006-10-01 00:00:00
abstract::The nervous system contains a diverse group of cells. Specification of the correct cell fate is obviously important for the proper function of the nervous system, yet how are the fates of different neurons determined during development? Very little is known about the underlying molecular mechanisms used in the mammali...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/0166-2236(90)90083-m
更新日期:1990-12-01 00:00:00
abstract::During the past 30 years, research into developmental disorders has fragmented, emphasizing differences rather than commonalities. We propose that reunification might be achieved by using a "neural-systems" approach. Deficits in dyslexia are attributed to an intact declarative learning system combined with an impaired...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2007.02.003
更新日期:2007-04-01 00:00:00
abstract::Neurons are dynamic cells that respond and adapt to stimuli throughout their long postmitotic lives. The structural and functional plasticity of neurons requires the regulated transcription of new gene products, and dysregulation of transcription in either the developing or adult brain impairs cognition. We discuss ho...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2018.02.009
更新日期:2018-05-01 00:00:00
abstract::Within the past decade intensive molecular genetic research has been carried out in the attempt to pinpoint chromosomal loci that may be linked to neuropsychiatric disorders. Joseph Martin reviews progress made in the application of molecular genetics to the study of diseases such as Huntington's disease, Alzheimer's ...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/0166-2236(89)90051-9
更新日期:1989-04-01 00:00:00
abstract::To successfully interact with their environments, developing organisms need to correctly process sensory information and generate motor outputs appropriate to their size and structure. Patterned sensory experience has long been known to induce various forms of developmental plasticity that ultimately shape mature neur...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2010.01.003
更新日期:2010-04-01 00:00:00
abstract::Mesolimbic dopaminergic neurons are thought to serve as a final common neural pathway for mediating reinforcement processes. However, several recent findings have challenged the view that mesolimbic dopamine has a crucial role in the maintenance of reinforcement processes, or the subjective rewarding actions of natura...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(99)01447-2
更新日期:1999-11-01 00:00:00
abstract::Discovery and interventions for neurological disorders have a unique capacity to galvanize public opinion over issues of access, human rights, decision making, and the definition of disease. Here we highlight five cases where beliefs and politics prevailed over evidence and ethics. We examine lessons from them about t...
journal_title:Trends in neurosciences
pub_type: 杂志文章
doi:10.1016/j.tins.2014.06.001
更新日期:2014-08-01 00:00:00
abstract::Presynaptic NMDA receptors (preNMDARs) play pivotal roles in excitatory neurotransmission and synaptic plasticity. They facilitate presynaptic neurotransmitter release and modulate mechanisms controlling synaptic maturation and plasticity during formative periods of brain development. There is an increasing understand...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2015.11.001
更新日期:2016-01-01 00:00:00
abstract::The colors perceived by humans in response to light stimuli are generally described in terms of four color categories (reds, greens, blues and yellows), the members of which are systematically arrayed around gray. This broadly accepted description of color sensation differs fundamentally from the light that induces it...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(02)02059-3
更新日期:2002-02-01 00:00:00
abstract::Korsakoff's disease is an amnesic syndrome associated with midline diencephalic and brain stem pathology. A number of neurochemical systems course through or near the loci of brain lesions found postmortem in Korsakoff patients, which has stimulated studies to learn whether these systems are implicated in amnesia. Dat...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/0166-2236(90)90146-2
更新日期:1990-08-01 00:00:00