Abstract：
:Oxytocin and vasopressin are regulators of anxiety, stress-coping, and sociality. They are released within hypothalamic and limbic areas from dendrites, axons, and perikarya independently of, or coordinated with, secretion from neurohypophysial terminals. Central oxytocin exerts anxiolytic and antidepressive effects, whereas vasopressin tends to show anxiogenic and depressive actions. Evidence from pharmacological and genetic association studies confirms their involvement in individual variation of emotional traits extending to psychopathology. Based on their opposing effects on emotional behaviors, we propose that a balanced activity of both brain neuropeptide systems is important for appropriate emotional behaviors. Shifting the balance between the neuropeptide systems towards oxytocin, by positive social stimuli and/or psychopharmacotherapy, may help to improve emotional behaviors and reinstate mental health.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Neumann ID,Landgraf Rdoi
10.1016/j.tins.2012.08.004subject
Has Abstractpub_date
2012-11-01 00:00:00pages
649-59issue
11eissn
0166-2236issn
1878-108Xpii
S0166-2236(12)00152-Xjournal_volume
35pub_type
杂志文章,评审abstract：:Dendritic spines, small bulbous postsynaptic compartments emanating from neuronal dendrites, have been thought to serve as basic units of memory storage. Despite their small size (~0.1 femtoliter), thousands of species of proteins exist in the spine, including receptors, channels, scaffolding proteins and signaling en...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2011.12.002
更新日期：2012-02-01 00:00:00
abstract：:Neuro-immune interactions are not only vital for the control of neurotropic pathogens, but also appear to influence brain development and homeostasis. During immune surveillance, T cells can patrol the CNS-associated border regions to sense pathogenic alterations. While access to the CNS parenchyma is restricted in th...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2019.07.008
更新日期：2019-10-01 00:00:00
abstract：:Several theories have proposed possible functions of adult neurogenesis in learning processes on a systems level, such as the avoidance of catastrophic interference and the encoding of temporal and contextual information, and in emotional behavior. Under the assumption of such functionality of new neurons, the questio...
journal_title：Trends in neurosciences
pub_type： 杂志文章
doi：10.1016/j.tins.2008.01.002
更新日期：2008-04-01 00:00:00
abstract：:In their 1994 paper, Monyer et al. described unique functional properties and cell type-specific expression of NMDA receptor (NMDAR) GluN2 subunits, suggesting that the roles of NMDAR vary across brain regions and throughout development. This influential work not only provided insight into how molecular diversity impa...
journal_title：Trends in neurosciences
pub_type： 杂志文章
doi：10.1016/j.tins.2018.06.001
更新日期：2018-08-01 00:00:00
abstract：:A variety of fatty acids regulate the activity of specific ion channels by mechanisms not involving the enzymatic pathways that convert arachidonic acid to oxygenated metabolites. Furthermore, these actions of fatty acids occur in patches of membrane excised from the cell and are not mediated by cellular signal transd...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/0166-2236(91)90069-7
更新日期：1991-03-01 00:00:00
abstract：:How does an extracellular guidance molecule direct multiple growth cones to different positions? The answer is important for understanding the development of complex neural connections. UNC-6 is a member of the netrin family of guidance proteins. It has phylogenetically conserved domains that mediate its different gui...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/s0166-2236(02)02206-3
更新日期：2002-08-01 00:00:00
abstract：:In a series of seminal behavioral and electrophysiological experiments, Knudsen and Konishi studied the mechanisms of hearing. Their 1979 article showed how the barn owl utilizes unique anatomical features for creating a systematic internal representation of auditory space. This established the barn owl as a prime mod...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2018.01.004
更新日期：2018-03-01 00:00:00
abstract：:The hippocampus is thought to automatically encode all experience, yet the vast majority of our experiences are not remembered later. Although psychological theories have postulated the existence of decay processes for declarative memory, the corresponding neurobiological mechanisms are unknown. Here we develop the hy...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2013.05.002
更新日期：2013-09-01 00:00:00
abstract：:Stress is a major trigger of seizures in people with epilepsy. Exposure to stress results in the release of several stress mediators throughout the brain, including the hippocampus, a region sensitive to stress and prone to seizures. Stress mediators interact with their respective receptors to produce distinct effects...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2017.08.004
更新日期：2017-11-01 00:00:00
abstract：:The activation of peripheral nociceptors is the subject of intense scrutiny, because of its significance in pain regulation. Genetic approaches, including homology cloning, difference cloning and transgenic manipulation of mice are providing useful insights into nociceptor function. Recent work suggests that transcrip...
journal_title：Trends in neurosciences
pub_type： 杂志文章
doi：10.1016/0166-2236(96)10030-8
更新日期：1996-06-01 00:00:00
abstract：:Immunoglobulin superfamily adhesion molecules are among the most abundant proteins in vertebrate and invertebrate nervous systems. Prominent family members are the neural cell adhesion molecules NCAM and L1, which were the first to be shown to be essential not only in development but also in synaptic function and as k...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2017.03.003
更新日期：2017-05-01 00:00:00
abstract：:Fear is an adaptive response to recognition of a potentially dangerous event. Glucocorticoids are essential for maintaining a wide variety of behavioral events by their regulation of numerous genes; one such gene encodes corticotrophin-releasing hormone (CRH). CRH is involved in diverse behavioral responses to changin...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2005.09.009
更新日期：2005-12-01 00:00:00
abstract：:The transition from short- to long-term memory requires lasting modulations of synaptic connectivity. In a variety of species and learning tasks, enhanced synthesis of glycoprotein cell-adhesion molecules (CAMs), such as neural CAM (NCAM) and Ll, 5-8 h post-training is a necessary step in this process. If the training...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/0166-2236(95)92774-k
更新日期：1995-11-01 00:00:00
abstract：:The physiology of the central nervous system (CNS) is built on a foundation of connection, integration, and the exchange of complex information among brain cells. Emerging evidence indicates that extracellular vesicles (EVs) are key players in the intercellular communication that underlies physiological processes such...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2018.03.006
更新日期：2018-06-01 00:00:00
abstract：:Cell replacement therapy has been proposed as a means to replace lost dopaminergic neurons in Parkinson's disease (PD). In most studies, the transplanted cells have been placed within the target site, the striatum, and not within the lesioned site, the substantia nigra, as the adult nigrostriatal pathway was thought t...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2011.01.003
更新日期：2011-03-01 00:00:00
abstract：:Acute inflammation plays an important role in host tissue defense against injury and infection, and also subsequent tissue repair. In the central nervous system parenchyma, following many types of insults, the acute inflammatory response to rapid neuronal degeneration or challenge with inflammatory substances differs ...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/0166-2236(93)90180-t
更新日期：1993-07-01 00:00:00
abstract：:The use of Drosophila as a suitable system to answer behavioural questions is usually based on the availability of mutant phenotypes. Indeed, the 'single-gene' approach to behaviour was a very illuminating strategy in practical and conceptual terms, and served to prove that the genetic mechanisms sustaining behaviour ...
journal_title：Trends in neurosciences
pub_type： 杂志文章
doi：10.1016/0166-2236(94)90137-6
更新日期：1994-11-01 00:00:00
abstract：:Most neurons are generated during development and are not replaced during adulthood, even if they are lost to injury or disease. However, it is firmly established that new neurons are generated in the dentate gyrus of the hippocampus of almost all adult mammals, including humans. Nevertheless, many questions remain re...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2015.07.005
更新日期：2015-09-01 00:00:00
abstract：:Brain dynamic changes associated with schizophrenia are largely equivocal, with interpretation complicated by many factors, such as the presence of therapeutic agents and the complex nature of the syndrome itself. Evidence for a brain-wide change in individual network oscillations, shared by all patients, is largely e...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2017.04.003
更新日期：2017-06-01 00:00:00
abstract：:The nervous system contains a diverse group of cells. Specification of the correct cell fate is obviously important for the proper function of the nervous system, yet how are the fates of different neurons determined during development? Very little is known about the underlying molecular mechanisms used in the mammali...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/0166-2236(90)90083-m
更新日期：1990-12-01 00:00:00
abstract：:Mossy fiber (MF) synapses are key stations for flow of information through the hippocampal formation. A major component of the output of the MF system is directed towards inhibitory interneurons. Recent studies have revealed that the functional properties of MF-interneuron synapses differ substantially from those of M...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/s0166-2236(02)02259-2
更新日期：2002-12-01 00:00:00
abstract：:ATP-sensitive K+ channels couple cell metabolism to electrical activity in nerve, muscle and endocrine cells, and play important roles in these tissues under both physiological and pathological conditions. The KATP channel is an octameric complex of two unrelated types of subunit: a pore-forming subunit (Kir6.2) and a...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/s0166-2236(98)01225-9
更新日期：1998-07-01 00:00:00
abstract：:To localize a sound source in space, the auditory system detects minute differences in the arrival time of a sound between the two ears. It has long been assumed that delay lines and coincidence detectors turn these time differences into a labelled line code for source position, but recent studies challenge this view....
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/s0166-2236(00)01953-6
更新日期：2001-12-01 00:00:00
abstract：:The fast-acting ligand-gated ion channels (LGICs) constitute a group that encompasses nicotinic ACh, 5-HT3, GABAA and glycine receptors. Undoubtedly, they all share a common evolutionary ancestor, and the group can therefore be considered to be a gene superfamily. Because the members of the superfamily are all recepto...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/0166-2236(95)93887-4
更新日期：1995-03-01 00:00:00
abstract：:Many behavioral responses are completed too quickly for the underlying sensory processes to rely on estimation of neural firing rates over extended time windows. Theoretically, first-spike times could underlie such rapid responses, but direct evidence has been lacking. Such evidence has now been uncovered in the human...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2004.10.010
更新日期：2005-01-01 00:00:00
abstract：:An abundance of experimental literature has established that gonadal steroid hormones are responsible for the sexual differentiation of neural circuitry, mediating a variety of reproductive behaviors and physiological mechanisms. These same hormones regulate the expression of reproductive function in the adult and may...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/0166-2236(90)90186-e
更新日期：1990-03-01 00:00:00
abstract：:The vertebrate neuromuscular junction (NMJ), a peripheral synapse formed between motoneuron and skeletal muscle, is characterized by a protracted postnatal period of maturation and life-long maintenance. In neuromuscular disorders such as congenital myasthenic syndromes (CMSs), disruptions of NMJ maturation and/or mai...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2012.04.005
更新日期：2012-07-01 00:00:00
abstract：:'Forward models' are increasingly recognized as a crucial explanatory concept in vertebrate motor control. The essential idea is that an important function implemented by nervous systems is prediction of the sensory consequences of action. This is often associated with higher cognitive capabilities; however, many of t...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2004.03.004
更新日期：2004-05-01 00:00:00
abstract：:The current dominant model of binaural sound localization proposes that the lateral position of a sound source is determined by the position of maximal activation within an array of binaural coincidence-detector neurons that are tuned to different interaural time differences (ITDs). The tuning of a neuron for an ITD i...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/S0166-2236(03)00140-1
更新日期：2003-07-01 00:00:00
abstract：:The term neuropeptide was advanced by de Wied and collaborators in the early seventies. At that time, they defined neuropeptides as endogenous substances synthesized in nerve cells and involved in nervous system functions. Since then, several studies have revealed that the very same 'neuropeptides' are also expressed ...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2003.09.003
更新日期：2003-11-01 00:00:00
