Abstract：
:In their 1994 paper, Monyer et al. described unique functional properties and cell type-specific expression of NMDA receptor (NMDAR) GluN2 subunits, suggesting that the roles of NMDAR vary across brain regions and throughout development. This influential work not only provided insight into how molecular diversity impacts synapse function, but also continues to inform new approaches for modulating brain circuits.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Swanger SA,Traynelis SFdoi
10.1016/j.tins.2018.06.001subject
Has Abstractpub_date
2018-08-01 00:00:00pages
486-488issue
8eissn
0166-2236issn
1878-108Xpii
S0166-2236(18)30159-0journal_volume
41pub_type
杂志文章abstract：:Potassium channels are crucial regulators of neuronal excitability, setting resting membrane potentials and firing thresholds, repolarizing action potentials and limiting excitability. Although most of our understanding of K+ channels is based on somatic recordings, there is good evidence that these channels are prese...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2004.02.012
更新日期：2004-04-01 00:00:00
abstract：:Progress in migraine research has been rapid in recent years, from both the basic science and the clinical perspectives. A new internationally accepted headache classification with operational diagnostic criteria was published in 1988, eliminating much diagnostic uncertainty. More than a decade of study of regional ce...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/0166-2236(91)90171-p
更新日期：1991-01-01 00:00:00
abstract：:Despite its highly diffusible nature, the gaseous signalling molecule nitric oxide (NO) can exert specific effects within the CNS and PNS. To date, the specificity of the actions of NO remains an unsolved puzzle. There are several plausible mechanisms that might account for this specificity in the context of autonomic...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/s0166-2236(02)02261-0
更新日期：2002-12-01 00:00:00
abstract：:Rhythmical brain activity around 5Hz can be observed in the prefrontal cortex under conditions requiring high levels of cognitive control. However, its temporal dynamics are still elusive. A recent research paper (Cooper et al. Neuroimage 2019;189:130-140) provides evidence that the temporal evolution of this frontal-...
journal_title：Trends in neurosciences
pub_type： 评论,杂志文章
doi：10.1016/j.tins.2019.02.006
更新日期：2019-05-01 00:00:00
abstract：:Antisocial aggression is a widespread and expensive social problem. Although aggressive behaviors and temperament are highly heritable, clinical and trait associations for the most promising candidate gene for aggression, MAOA, have been largely inconsistent. We suggest that limitations inherent to that approach might...
journal_title：Trends in neurosciences
pub_type： 杂志文章
doi：10.1016/j.tins.2007.12.006
更新日期：2008-03-01 00:00:00
abstract：:The orexins (or hypocretins) are neuropeptide transmitters made exclusively in hypothalamic neurons that have extensive CNS projections. Previous studies reported that this system is most strongly associated with feeding, arousal and the maintenance of waking. We review here recent studies that reveal a novel and impo...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2006.08.002
更新日期：2006-10-01 00:00:00
abstract：:In the classical picture of brain function, electrical impulses are initiated in sensory organs and spread rapidly down axons, jumping synaptic clefts by neurochemical transmission. Patterns of electrical activity generated in this way integrate information throughout the brain and result in coordinated motor output. ...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/0166-2236(89)90089-1
更新日期：1989-11-01 00:00:00
abstract：:Acute inflammation plays an important role in host tissue defense against injury and infection, and also subsequent tissue repair. In the central nervous system parenchyma, following many types of insults, the acute inflammatory response to rapid neuronal degeneration or challenge with inflammatory substances differs ...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/0166-2236(93)90180-t
更新日期：1993-07-01 00:00:00
abstract：:Currently available antibodies to the P2X(7) receptor are unreliable determinants of neuronal P2X(7) immunoreactivity, owing to staining of a "P2X(7)-like" protein that is not eliminated by legitimate P2X(7) gene-knockout approaches. Despite this, compelling electrophysiological and pharmacological data strongly suppo...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2006.03.003
更新日期：2006-05-01 00:00:00
abstract：:P2X receptors are cation-selective ion channels that open on binding to extracellular ATP; they play a role in fast synaptic transmission between neurones, and from autonomic nerves to smooth muscles. Isolation of cDNAs that encode P2X receptors in the smooth muscle of vas deferens and in phaeochromocytoma cells indic...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/0166-2236(95)93907-f
更新日期：1995-05-01 00:00:00
abstract：:Huntington's disease is an inherited neurodegenerative disorder, the cause of which is unknown. Excitotoxicity, mitochondrial dysfunction and oxidative stress are all likely to contribute to the striatal cell death that occurs in this disorder. There are accumulating data indicating that under specific circumstances, ...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/s0166-2236(00)01568-x
更新日期：2000-06-01 00:00:00
abstract：:Modern neuroscientific techniques that specifically manipulate and measure neuronal activity in behaving animals now allow bridging of the gap from the cellular to the behavioral level. However, in doing so, they also pose new challenges. Research using incompletely defined manipulations in a high-dimensional space wi...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2018.01.002
更新日期：2018-03-01 00:00:00
abstract：:Recently, two large multigene families of putative G-protein-linked receptors that are expressed in distinct subpopulations of neurones in the vomeronasal organ have been identified. These receptors probably mediate pheromone detection. The most surprising aspects of these findings are that there are so many receptors...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/s0166-2236(98)01274-0
更新日期：1998-11-01 00:00:00
abstract：:The term neuropeptide was advanced by de Wied and collaborators in the early seventies. At that time, they defined neuropeptides as endogenous substances synthesized in nerve cells and involved in nervous system functions. Since then, several studies have revealed that the very same 'neuropeptides' are also expressed ...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2003.09.003
更新日期：2003-11-01 00:00:00
abstract：:Sleep can facilitate memory formation, but its role in cortical plasticity is poorly understood. A recent study found that sleep, following monocular deprivation (MD), facilitated cortical changes in ocular dominance. The magnitude of plasticity was similar to that observed after continued MD, and larger than that see...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/s0166-2236(00)02005-1
更新日期：2002-01-01 00:00:00
abstract：:Several modes of synaptic vesicle release, retrieval and recycling have been identified. In a well-established mode of exocytosis, termed 'full-collapse fusion', vesicles empty their neurotransmitter content fully into the synaptic cleft by flattening out and becoming part of the presynaptic membrane. The fused vesicl...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2008.08.005
更新日期：2008-11-01 00:00:00
abstract：:Depression is a common cause of mortality and morbidity, but the biological bases of the deficits in emotional and cognitive processing remain incompletely understood. Current antidepressant therapies are effective in only some patients and act slowly. Here, we propose an excitatory synapse hypothesis of depression in...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2015.03.003
更新日期：2015-05-01 00:00:00
abstract：:Precisely wired neuronal circuits process sensory information in a learning- and context-dependent manner in order to govern behavior. Simple sensory decision-making tasks in rodents are now beginning to reveal the contributions of distinct cell types and brain regions participating in the conversion of sensory inform...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2018.08.011
更新日期：2019-01-01 00:00:00
abstract：:Aging is characterized by decrements in maximum function and accumulation of mitochondrial DNA mutations, which are best observed in organs such as the brain that contain post-mitotic cells. Oxygen radicals are increasingly considered responsible for part of these aging changes. Comparative studies of animals with dif...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2004.07.005
更新日期：2004-10-01 00:00:00
abstract：:Stress is a major trigger of seizures in people with epilepsy. Exposure to stress results in the release of several stress mediators throughout the brain, including the hippocampus, a region sensitive to stress and prone to seizures. Stress mediators interact with their respective receptors to produce distinct effects...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2017.08.004
更新日期：2017-11-01 00:00:00
abstract：:Mis-sense mutations of presenilin 1 increase the release of amyloidogenic peptide from amyloid precursor protein (APP) and are a major cause of familial Alzheimer's Disease. Loss-of-function mutations of presenilins in the mouse, Caenorhabditis elegans and Drosophila result in severe developmental defects caused by di...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/s0166-2236(99)01455-1
更新日期：1999-10-01 00:00:00
abstract：:Neural tube closure fails in both mouse and Xenopus when dishevelled and other components of the planar-cell-polarity pathway are misregulated. The underlying defect involves a failure of convergent extension in the midline of the early neural plate. Although bilateral neural folds form, they are abnormally far apart ...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/S0166-2236(03)00212-1
更新日期：2003-09-01 00:00:00
abstract：:More often than not, action potentials fail to trigger neurotransmitter release. And even when neurotransmitter is released, the resulting change in synaptic conductance is highly variable. Given the energetic cost of generating and propagating action potentials, and the importance of information transmission across s...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2020.03.009
更新日期：2020-06-01 00:00:00
abstract：:In the central nervous system (CNS) the function of retinoic acid, the active metabolite of vitamin A, is best understood from its action in guiding embryonic development; as development comes to completion, retinoic acid signaling declines. However, it is increasingly recognized that this signaling mechanism does not...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2012.08.005
更新日期：2012-12-01 00:00:00
abstract：:Striatal enriched tyrosine phosphatase (STEP) has recently been identified as a crucial player in the regulation of synaptic function. It is restricted to neurons within the CNS and acts by downregulating the activity of MAP kinases, the tyrosine kinase Fyn and NMDA receptors. By modulating these substrates, STEP acts...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2006.06.007
更新日期：2006-08-01 00:00:00
abstract：:Tsao et al. have recently used functional magnetic resonance imaging to compare processing for moving stereoscopic forms in macaque and human brains. Most humans exhibited activation in a swath of lateral occipital areas, extending into the intraparietal sulcus, with a limited version of the same pattern in monkeys. H...
journal_title：Trends in neurosciences
pub_type： 杂志文章
doi：10.1016/j.tins.2003.12.009
更新日期：2004-03-01 00:00:00
abstract：:Neuro-immune interactions are not only vital for the control of neurotropic pathogens, but also appear to influence brain development and homeostasis. During immune surveillance, T cells can patrol the CNS-associated border regions to sense pathogenic alterations. While access to the CNS parenchyma is restricted in th...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2019.07.008
更新日期：2019-10-01 00:00:00
abstract：:Conditioning and extinction of fear have traditionally been viewed as two independent learning processes for encoding representations of contexts or cues (conditioned stimuli, CS), aversive events (unconditioned stimuli, US), and their relationship. Based on the analysis of protein kinase signaling patterns in neurons...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2011.10.003
更新日期：2012-03-01 00:00:00
abstract：:Fear is an adaptive response to recognition of a potentially dangerous event. Glucocorticoids are essential for maintaining a wide variety of behavioral events by their regulation of numerous genes; one such gene encodes corticotrophin-releasing hormone (CRH). CRH is involved in diverse behavioral responses to changin...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2005.09.009
更新日期：2005-12-01 00:00:00
abstract：:In mature rodents, whisker-related patterns are known to be present in three levels of the brain: the brainstem trigeminal nuclei, the ventrobasal thalamus and the somatosensory cortex. These patterns have been demonstrated using neuroanatomical tracing techniques, histological and histochemical staining methods and e...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/s0166-2236(97)01217-4
更新日期：1998-06-01 00:00:00
