Abstract：
:The use of Drosophila as a suitable system to answer behavioural questions is usually based on the availability of mutant phenotypes. Indeed, the 'single-gene' approach to behaviour was a very illuminating strategy in practical and conceptual terms, and served to prove that the genetic mechanisms sustaining behaviour could be analysed. However, the essence of neurogenetics goes for beyond the utilitarian use of mutants as tools to dissect behavior. Our main contention is that the study of the genetic basis of behaviour requires the study of genomes, rather than single genes, and their functional organization. Here, we use two aspects of behaviour, olfaction and movement control, as examples to illustrate the intricate, albeit understandable, relationship between the genome and behaviour. At present, these examples offer only a glimpse into this relationship. Further progress might be reached if studies on the regulation of functionally related genes are undertaken. On these grounds, it appears that the answer to many fundamental questions about behaviour that are amendable to experimentation might come from the work on Drosophila, providing that the required multidisciplinary efforts are focused on this organism.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Ferrús A,Canal Idoi
10.1016/0166-2236(94)90137-6subject
Has Abstractpub_date
1994-11-01 00:00:00pages
479-86issue
11eissn
0166-2236issn
1878-108Xpii
0166-2236(94)90137-6journal_volume
17pub_type
杂志文章abstract：:The construction of artificial walking machines has been a challenging task for engineers for several centuries. Advances in computer technology have stimulated this research in the past two decades, and enormous progress has been made, particularly in recent years. Nevertheless, in comparing the walk of a six-legged ...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/0166-2236(90)90057-h
更新日期：1990-01-01 00:00:00
abstract：:A large body of evidence suggests that neural plasticity contributes to learning and disease. Recent studies suggest that cortical map plasticity is typically a transient phase that improves learning by increasing the pool of task-relevant responses. Here, I discuss a new perspective on neural plasticity and suggest h...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2012.09.002
更新日期：2012-12-01 00:00:00
abstract：:The strange and unpleasant sensations (paraesthesiae) or asynchronous motor-unit activation (fasciculation) that result from a period of limb ischaemia are examples of ectopic discharge in peripheral nerves. Ectopic activity also results from demyelination and is associated with serious neurological conditions, such a...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/s0166-2236(00)01645-3
更新日期：2000-11-01 00:00:00
abstract：:Priming is the process by which vesicles become available for fusion at nerve terminals and is modulated by numerous proteins and second messengers. One of the prominent members of this diverse family is tomosyn. Tomosyn has been identified as a syntaxin-binding protein; it inhibits vesicle priming, but its mode of ac...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2009.01.004
更新日期：2009-05-01 00:00:00
abstract：:The production by the pyridine MPTP of a parkinsonian syndrome strikingly similar to the 'idiopathic' disorder, and the paucity of evidence supporting a hereditary or infectious etiology for Parkinson's disease (PD), have stimulated a search for environmental chemicals resembling MPTP that might cause PD. In support o...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/0166-2236(89)90135-5
更新日期：1989-02-01 00:00:00
abstract：:Chronic pain is sustained by central neuronal sensitization, with many similar characteristics irrespective of the type of injury incurred. Nevertheless, pain arising from nerve injury (neuropathic pain) is resistant to centrally acting analgesics, whereas inflammatory pain responds well. New research indicates that t...
journal_title：Trends in neurosciences
pub_type： 杂志文章
doi：10.1016/j.tins.2004.03.014
更新日期：2004-06-01 00:00:00
abstract：:Several theories have proposed possible functions of adult neurogenesis in learning processes on a systems level, such as the avoidance of catastrophic interference and the encoding of temporal and contextual information, and in emotional behavior. Under the assumption of such functionality of new neurons, the questio...
journal_title：Trends in neurosciences
pub_type： 杂志文章
doi：10.1016/j.tins.2008.01.002
更新日期：2008-04-01 00:00:00
abstract：:In the brain, highly connected and heterogeneous GABAergic cells are crucial in controling the activity of neuronal networks. They accomplish this task by communicating through remarkably diverse sets of inhibitory processes, the complexity of which is reflected by the variety of interneuron classification schemes pro...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2004.07.002
更新日期：2004-09-01 00:00:00
abstract：:The principal ovarian estrogen, estradiol, and brain-derived neurotrophic factor (BDNF) have widespread effects on the CNS that have usually been studied independently. This article examines the similarities in the effects of estradiol and BDNF in the hippocampus, in light of the evidence that estradiol can induce BDN...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2004.12.005
更新日期：2005-02-01 00:00:00
abstract：:Astrocytes, which constitute the most abundant cell type in mammalian brain, are extensively coupled to one another through gap junctions composed mainly of connexin43. In regions exhibiting high levels of connexin43 expression, tens of astrocytes are labeled following single-cell intracellular injection. Importantly,...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/0166-2236(96)10046-1
更新日期：1996-08-01 00:00:00
abstract：:Age-related hearing loss (ARHL) is a common problem for older adults, leading to communication difficulties, isolation, and cognitive decline. Recently, hearing loss has been identified as potentially the most modifiable risk factor for dementia. Listening in challenging situations, or when the auditory system is dama...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2020.07.005
更新日期：2020-10-01 00:00:00
abstract：:Navigation depends upon neural systems that monitor spatial location and head orientation. Recent developmental findings have led some to conclude that these systems are innate. Such claims are premature. But also, there are more meaningful ways to arrive at answers about developmental origins than by invoking the out...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2015.01.001
更新日期：2015-02-01 00:00:00
abstract：:NMDA receptors (NMDARs) are ion channels activated by the excitatory neurotransmitter glutamate and are essential to all aspects of brain function, including learning and memory formation. Missense mutations distributed throughout NMDAR subunits have been associated with an array of neurological disorders. Recent stru...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2017.01.001
更新日期：2017-03-01 00:00:00
abstract：:Motoneurones are known to die (1) during embryonic development (naturally occurring cell death), (2) early in postnatal development after axonal injury, and (3) as a consequence of disease, such as spinal muscular atrophy or (in later life) amyotrophic lateral sclerosis. Naturally occurring motoneurone death has been ...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/0166-2236(92)90014-y
更新日期：1992-03-01 00:00:00
abstract：:Hebbian synaptic learning requires co-activation of presynaptic and postsynaptic neurons. However, under some conditions, information regarding the postsynaptic action potential, carried by backpropagating action potentials, can be strongly degraded before it reaches the distal exhibit Hebbian long-term potentiation (...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2003.12.004
更新日期：2004-02-01 00:00:00
abstract：:Both ageing and chronic stress are associated with altered brain plasticity, dysregulation of the immune system, and an increased risk of developing brain disorders; all of which have consequences for cognitive and emotional processing. Here we examine the similarities between behavioural changes during ageing and str...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2014.11.001
更新日期：2015-01-01 00:00:00
abstract：:Modern neuroscientific techniques that specifically manipulate and measure neuronal activity in behaving animals now allow bridging of the gap from the cellular to the behavioral level. However, in doing so, they also pose new challenges. Research using incompletely defined manipulations in a high-dimensional space wi...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2018.01.002
更新日期：2018-03-01 00:00:00
abstract：:The appearance of Santiago Ramón y Cajal in the world of neuroscience provoked a radical change in the course of its history. Cajal's studies of the microanatomy of virtually the whole CNS and his observations regarding degeneration and regeneration, together with his theories about the function, development and plast...
journal_title：Trends in neurosciences
pub_type： 传,历史文章,杂志文章
doi：10.1016/s0166-2236(02)02214-2
更新日期：2002-09-01 00:00:00
abstract：:Central processing of olfactory information has been analyzed in the mushroom body of Drosophila by Ca(2+) imaging, extending such analysis of odor coding to the second relay of the olfactory system. Different odors, and different concentrations of a particular odor, yield distinct spatial patterns of activity. Mutati...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/s0166-2236(00)01895-6
更新日期：2001-09-01 00:00:00
abstract：:Axon interruption elicits a complex neuronal response that leaves neurons poised precariously between death and regeneration. The signals underlying this dichotomy are not fully understood. The transcription factor c-Jun is one of the earliest and most consistent markers for neurons that respond to nerve-fiber transec...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/s0166-2236(96)01000-4
更新日期：1997-05-01 00:00:00
abstract：:Gliomas are terrifying primary brain tumors for which patient outlook remains bleak. Recent research provides novel insights into the unique biology of gliomas. For example, these tumors exhibit an unexpected pluripotency that enables them to grow their own vasculature. They have an unusual ability to navigate tortuou...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2012.05.001
更新日期：2012-09-01 00:00:00
abstract：:Oxytocin and vasopressin are regulators of anxiety, stress-coping, and sociality. They are released within hypothalamic and limbic areas from dendrites, axons, and perikarya independently of, or coordinated with, secretion from neurohypophysial terminals. Central oxytocin exerts anxiolytic and antidepressive effects, ...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2012.08.004
更新日期：2012-11-01 00:00:00
abstract：:Sensory representations are repeatedly transformed by neural computations that determine which of their attributes can be effectively processed at each stage. Whereas some early computations are common across multiple sensory systems, they can utilize dissimilar underlying mechanisms depending on the properties of eac...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2009.12.004
更新日期：2010-03-01 00:00:00
abstract：:The hereditary ataxias are a group of inherited neurodegenerative disorders characterized by progressive ataxia that results from degeneration of the cerebellum and its afferent and efferent connections. Recent molecular research has led not only to the discovery of a number of causative mutations, but also shed light...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/s0166-2236(98)01315-0
更新日期：1998-09-01 00:00:00
abstract：:Volumetric measurements of the brain regions in eight-year-old children indicate that the poor cognitive and behavioral outcomes noted in ex-preterm neonates are associated with reduced volumes of specific regions in the brain. Recent literature suggests that this reduction might result from enhanced apoptosis or exci...
journal_title：Trends in neurosciences
pub_type： 杂志文章
doi：10.1016/s0166-2236(00)01747-1
更新日期：2001-03-01 00:00:00
abstract：:CNS myelin inhibits axonal outgrowth in vitro and is one of several obstacles to functional recovery following spinal cord injury. Central to our current understanding of myelin-mediated inhibition are the membrane protein Nogo and the Nogo-66 receptor (NgR). New findings implicate NgR as a point of convergence in sig...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/S0166-2236(03)00062-6
更新日期：2003-04-01 00:00:00
abstract：:The laboratory mouse has emerged as a primary model organism for studying axon regeneration after experimental spinal cord injury, owing to its genetic amenability. Mutant mouse models are contributing significantly to our understanding of the molecular mechanisms of axon regeneration failure in the adult mammalian ce...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2006.09.005
更新日期：2006-11-01 00:00:00
abstract：:The colors perceived by humans in response to light stimuli are generally described in terms of four color categories (reds, greens, blues and yellows), the members of which are systematically arrayed around gray. This broadly accepted description of color sensation differs fundamentally from the light that induces it...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/s0166-2236(02)02059-3
更新日期：2002-02-01 00:00:00
abstract：:Since early anatomical descriptions, the existence of dendritic spines has stimulated intense curiosity and speculation about their regulation and function. Research over the past three decades has described an impressive mutability in dendritic-spine number and morphology under a variety of physiological circumstance...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/s0166-2236(00)01576-9
更新日期：2000-04-01 00:00:00
abstract：:It has been suggested, on the basis of neuroanatomical and behavioural data, that olfactory discrimination in the rat provides privileged access to higher cognitive processes, involves the acquisition of a learning-set and, importantly, can be used to model human hippocampal function and dysfunction. In this article, ...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/0166-2236(93)90043-l
更新日期：1993-01-01 00:00:00
