Abstract:
:A variety of fatty acids regulate the activity of specific ion channels by mechanisms not involving the enzymatic pathways that convert arachidonic acid to oxygenated metabolites. Furthermore, these actions of fatty acids occur in patches of membrane excised from the cell and are not mediated by cellular signal transduction pathways that require soluble factors such as nucleotides and calcium. Thus, fatty acids themselves appear to regulate the action of channels directly, much as they regulate the action of several purified enzymes, and might constitute a new class of first or second messengers acting on ion channels.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Ordway RW,Singer JJ,Walsh JV Jrdoi
10.1016/0166-2236(91)90069-7subject
Has Abstractpub_date
1991-03-01 00:00:00pages
96-100issue
3eissn
0166-2236issn
1878-108Xpii
0166-2236(91)90069-7journal_volume
14pub_type
杂志文章,评审abstract::Adaptation to the ever-changing world is critical for survival, and our brains are particularly tuned to remember events that differ from previous experiences. Novel experiences induce dopamine release in the hippocampus, a process which promotes memory persistence. While axons from the ventral tegmental area (VTA) we...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2018.10.002
更新日期:2019-02-01 00:00:00
abstract::The proportional relation between circulating vasopressin concentration and plasma osmolality is fundamental for body fluid homeostasis. Although changes in the sensitivity of this relation are associated with pathophysiological conditions, central mechanisms modulating osmoregulatory gain are unknown. Here, we review...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2009.11.004
更新日期:2010-02-01 00:00:00
abstract::Women experience many pain conditions more frequently when compared with men, but the biological mechanisms underlying sex differences in pain remain poorly understood. In particular, little is known about possible sex differences in peripheral nociceptors, the fundamental building blocks of pain transmission. Emergin...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2020.06.003
更新日期:2020-08-01 00:00:00
abstract::Chronic pain is a major medical problem that is resistant to conventional medical intervention. It also causes emotional changes such as anxiety and fear. Furthermore, anxiety or fear often enhances the suffering of pain. Based on recent studies, I propose chronic anxiety triggered by injury or chronic pain is mediate...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2016.01.006
更新日期:2016-03-01 00:00:00
abstract::Several modes of synaptic vesicle release, retrieval and recycling have been identified. In a well-established mode of exocytosis, termed 'full-collapse fusion', vesicles empty their neurotransmitter content fully into the synaptic cleft by flattening out and becoming part of the presynaptic membrane. The fused vesicl...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2008.08.005
更新日期:2008-11-01 00:00:00
abstract::Nearly 30 years ago, a debate over two disparate models of synaptic vesicle retrieval arose. Subsequent investigations to determine which model was correct proved inconclusive and served only to further the debate. However, recent evidence has begun to suggest that both models are valid and relevant in understanding t...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(00)01769-0
更新日期:2001-04-01 00:00:00
abstract::Inflammation in the central nervous system (CNS) has been linked to demyelination and remyelination. Using zebrafish and mouse models of demyelination and remyelination, Cunha et al. now describe a novel role for myeloid differentiation factor 88 (MyD88) signaling in supporting remyelination by promoting myeloid cell-...
journal_title:Trends in neurosciences
pub_type: 评论,杂志文章
doi:10.1016/j.tins.2020.04.005
更新日期:2020-07-01 00:00:00
abstract::ATP-sensitive K+ channels couple cell metabolism to electrical activity in nerve, muscle and endocrine cells, and play important roles in these tissues under both physiological and pathological conditions. The KATP channel is an octameric complex of two unrelated types of subunit: a pore-forming subunit (Kir6.2) and a...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(98)01225-9
更新日期:1998-07-01 00:00:00
abstract::The recent advent of novel high-resolution imaging methods has created a flurry of exciting observations that address a century-old question: what are biological signals that regulate formation and elimination of dendritic spines? Contrary to the traditional belief that the spine is a stable storage site of long-term ...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(99)01499-x
更新日期:2000-02-01 00:00:00
abstract::One of the major problems of living in a rich visual environment is deciding which particular object or location should be chosen for complete processing or attention; that is, deciding which object is most salient at any particular time. The pulvinar has enlarged substantially during evolution, although little has pr...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/0166-2236(92)90354-b
更新日期:1992-04-01 00:00:00
abstract::Volumetric measurements of the brain regions in eight-year-old children indicate that the poor cognitive and behavioral outcomes noted in ex-preterm neonates are associated with reduced volumes of specific regions in the brain. Recent literature suggests that this reduction might result from enhanced apoptosis or exci...
journal_title:Trends in neurosciences
pub_type: 杂志文章
doi:10.1016/s0166-2236(00)01747-1
更新日期:2001-03-01 00:00:00
abstract::The myelinated axon provides a model in which it is possible to examine how various types of ion channels are incorporated into a membrane to form an excitable neuronal process. The available evidence now indicates that mammalian myelinated fibers contain a repertoire of physiologically active membrane molecules inclu...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/0166-2236(90)90068-l
更新日期:1990-02-01 00:00:00
abstract::Brain dynamic changes associated with schizophrenia are largely equivocal, with interpretation complicated by many factors, such as the presence of therapeutic agents and the complex nature of the syndrome itself. Evidence for a brain-wide change in individual network oscillations, shared by all patients, is largely e...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2017.04.003
更新日期:2017-06-01 00:00:00
abstract::Ejaculation, although mediated by a spinal ejaculation generator, is subject to descending supraspinal modulation from several brain regions. 5-Hydroxytryptamine (5-HT or serotonin) is involved in ejaculatory control, with its ejaculation-retarding effects likely to be attributable to activation of 5-HT1B and 5-HT2C r...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2006.12.002
更新日期:2007-02-01 00:00:00
abstract::Unlike most mammalian species, the prairie vole is highly affiliative, forms enduring social bonds between mates and displays biparental behavior. Over two decades of research on this species has enhanced our understanding of the neurobiological basis not only of monogamy, social attachment and nurturing behaviors but...
journal_title:Trends in neurosciences
pub_type: 杂志文章
doi:10.1016/j.tins.2009.11.006
更新日期:2010-02-01 00:00:00
abstract::Notions of what constitutes a neurotransmitter have changed markedly with the advent in the past decade of synaptic molecules, which satisfy key neurotransmitter criteria but differ radically from classical transmitters. Thus, NO and carbon monoxide are neither stored in synaptic vesicles nor released by exocytosis. T...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(00)01716-1
更新日期:2001-02-01 00:00:00
abstract::As a neurodevelopmental disorder with serious lifelong consequences, autism has received considerable attention from neuroscientists and geneticists. We present a hypothesis of mechanisms plausibly affected during brain development in autism, based on neural pathways that are associated with social behavior and connec...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2019.05.002
更新日期:2019-07-01 00:00:00
abstract::How the brain becomes lateralized is poorly understood. By contrast, much is known about molecular cues that specify the left-right axis of the body, fashioning the asymmetric morphology and positioning of the visceral organs. In zebrafish, the Nodal signaling pathway functions in visceral asymmetry and also in the em...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/S0166-2236(03)00129-2
更新日期:2003-06-01 00:00:00
abstract::Previous studies have demonstrated that oligodendrocytes in the spinal cord and brainstem originate from restricted domains of ventral neuroepithelium under the influence of sonic hedgehog protein (SHH). However, the origin of oligodendrocytes in the telencephalon, the most anterior part of the CNS, has not been estab...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(02)02145-8
更新日期:2002-05-01 00:00:00
abstract::The appearance of Santiago Ramón y Cajal in the world of neuroscience provoked a radical change in the course of its history. Cajal's studies of the microanatomy of virtually the whole CNS and his observations regarding degeneration and regeneration, together with his theories about the function, development and plast...
journal_title:Trends in neurosciences
pub_type: 传,历史文章,杂志文章
doi:10.1016/s0166-2236(02)02214-2
更新日期:2002-09-01 00:00:00
abstract::Most neurons are generated during development and are not replaced during adulthood, even if they are lost to injury or disease. However, it is firmly established that new neurons are generated in the dentate gyrus of the hippocampus of almost all adult mammals, including humans. Nevertheless, many questions remain re...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2015.07.005
更新日期:2015-09-01 00:00:00
abstract::Potassium channels are crucial regulators of neuronal excitability, setting resting membrane potentials and firing thresholds, repolarizing action potentials and limiting excitability. Although most of our understanding of K+ channels is based on somatic recordings, there is good evidence that these channels are prese...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2004.02.012
更新日期:2004-04-01 00:00:00
abstract::Chronic pain secondary to neuronal injury is actively and continuously modulated at multiple locations along the sensory neuraxis. Here, we describe how nociceptive neurons of the spinal cord and thalamus process and communicate nociceptive information in terms of precisely calibrated firing patterns. We then discuss ...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2008.11.004
更新日期:2009-02-01 00:00:00
abstract::For organs innervated by the autonomic nervous system, it is generally held that neuroeffector transmission is achieved by varicosities releasing transmitters some distance from the membranes of target cells. Transmitters are thought to diffuse through the extracellular space and interact with post-junctional receptor...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/0166-2236(92)90024-3
更新日期:1992-02-01 00:00:00
abstract::Communication is a central theme in biology. Consequently, specialized structures have evolved to permit rapid communication among cells, tissues, organs, and physiological systems, thus enhancing the overall function and adaptation of the organism. A prime example is the neuronal synapse. In the brain, synaptic commu...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2015.06.001
更新日期:2015-08-01 00:00:00
abstract::In contrast to innocuous stimuli, which only have transient effects when applied to the body surface, noxious stimuli generate persistent changes in the nervous system. This nociceptive memory manifests itself most prominently as a post-injury sensitization where, after tissue damage, the avoidance reaction and pain t...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/0166-2236(91)90024-o
更新日期:1991-02-01 00:00:00
abstract::Advances in understanding the biology of neurotrophic factors and their signaling pathways have provided important insights into the normal growth, differentiation and maintenance of neurons. Stimulated by neuropathological observations and genetic discoveries, studies in cell and animal models of neurodegenerative di...
journal_title:Trends in neurosciences
pub_type: 杂志文章
doi:10.1016/S0166-2236(02)00038-3
更新日期:2003-02-01 00:00:00
abstract::Serotonin (5-HT) 5-HT(3) receptors are ligand-gated ion channels, which are generally thought to be involved in the presynaptic modulation of neurotransmitter release. However, analysis of published data reveals that most of the evidence for the alleged presynaptic role of 5-HT(3) receptors in modulating CNS neurotran...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(00)01662-3
更新日期:2000-12-01 00:00:00
abstract::Priming is the process by which vesicles become available for fusion at nerve terminals and is modulated by numerous proteins and second messengers. One of the prominent members of this diverse family is tomosyn. Tomosyn has been identified as a syntaxin-binding protein; it inhibits vesicle priming, but its mode of ac...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2009.01.004
更新日期:2009-05-01 00:00:00
abstract::It is now clear that cytokines traditionally viewed as immune modulators participate in inflammatory responses within the adult nervous system. However, in the developing nervous system hematolymphopoietic cytokines also play a role unrelated to neural-immune interactions. Instead, many of these factors subserve prima...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(96)01045-4
更新日期:1997-08-01 00:00:00