Abstract：
:There are pluripotent stem cells in the adult brain that might not be very different from those found in bone marrow. Recent and profound advances in the field of neuropoiesis, which often rely on insights from studies of hematopoiesis and in some instances use cross-paradigms with this field, have already revealed that bone marrow has much in common with so-called 'brain marrow'. Proliferative primogenitors and developmentally regulated molecules are hallmarks of both neuropoiesis and hematopoiesis. This article will focus on recent advances in neuropoiesis within a central core of the mature brain that is referred to as brain marrow, discussing its pluripotency and proliferative capacity, in vitro and molecular assays used in its study, and markers of neuropoietic stem/progenitor cells. As hematopoiesis research has led to the discovery of numerous morphogenetic factors, it is anticipated that studies of neuropoiesis should also uncover many new factors and genes that affect the growth and differentiation of neural cells. Recent breakthroughs in the stem-cell field prompt an inclusion of rationale for the persistence of normal stem/progenitor cells even in the aged brain. By analogy with hematopoiesis research, a thorough investigation of brain marrow should provide basic insights into developmental and persistent neurogenesis while anticipating cell-transplant and gene therapies for debilitating neurological diseases.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Scheffler B,Horn M,Blumcke I,Laywell ED,Coomes D,Kukekov VG,Steindler DAdoi
10.1016/s0166-2236(99)01416-2subject
Has Abstractpub_date
1999-08-01 00:00:00pages
348-57issue
8eissn
0166-2236issn
1878-108Xpii
S0166-2236(99)01416-2journal_volume
22pub_type
杂志文章,评审abstract：:Over the past couple of years, it has become evident that some males carrying the fragile X mental retardation (FMR1) premutation, typically viewed to be normal, in fact manifest a neurodegenerative disease with ataxia and tremor. FMR1 premutation alleles uniquely produce FMR1 transcripts with an elongated CGG repeat,...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
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abstract：:Age-related hearing loss (ARHL) is a common problem for older adults, leading to communication difficulties, isolation, and cognitive decline. Recently, hearing loss has been identified as potentially the most modifiable risk factor for dementia. Listening in challenging situations, or when the auditory system is dama...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
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journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2003.12.007
更新日期：2004-03-01 00:00:00
abstract：:A defining feature of the vertebrate nervous system is the ensheathment of axons by myelin, a multilamellar membrane containing a small group of proteins and an abundance of the galactolipid galactocerebroside (GalC) and its sulfated derivative sulfatide. Several in vitro studies have suggested that these galactolipid...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/s0166-2236(97)01178-8
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journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
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journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2006.06.014
更新日期：2006-10-01 00:00:00
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journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2018.07.002
更新日期：2018-09-01 00:00:00
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journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/s0166-2236(00)01716-1
更新日期：2001-02-01 00:00:00
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journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/s0166-2236(02)02241-5
更新日期：2002-10-01 00:00:00
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journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/0166-2236(92)90081-i
更新日期：1992-08-01 00:00:00
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journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2006.03.003
更新日期：2006-05-01 00:00:00
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journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2019.12.004
更新日期：2020-02-01 00:00:00
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journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/s0166-2236(98)01315-0
更新日期：1998-09-01 00:00:00
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journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/0166-2236(93)90156-g
更新日期：1993-06-01 00:00:00
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journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2013.04.009
更新日期：2013-08-01 00:00:00
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journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2006.06.007
更新日期：2006-08-01 00:00:00
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journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/s0166-2236(00)02127-5
更新日期：2002-04-01 00:00:00
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journal_title：Trends in neurosciences
pub_type： 杂志文章
doi：10.1016/j.tins.2004.03.014
更新日期：2004-06-01 00:00:00
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journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/0166-2236(91)90126-f
更新日期：1991-06-01 00:00:00
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journal_title：Trends in neurosciences
pub_type： 杂志文章
doi：10.1016/s0166-2236(00)01747-1
更新日期：2001-03-01 00:00:00
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journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2017.01.001
更新日期：2017-03-01 00:00:00
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journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/s0166-2236(00)01836-1
更新日期：2001-07-01 00:00:00
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journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2003.12.001
更新日期：2004-02-01 00:00:00
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journal_title：Trends in neurosciences
pub_type： 评论,杂志文章
doi：10.1016/j.tins.2019.02.006
更新日期：2019-05-01 00:00:00
abstract：:Sleep can facilitate memory formation, but its role in cortical plasticity is poorly understood. A recent study found that sleep, following monocular deprivation (MD), facilitated cortical changes in ocular dominance. The magnitude of plasticity was similar to that observed after continued MD, and larger than that see...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/s0166-2236(00)02005-1
更新日期：2002-01-01 00:00:00
abstract：:Intracellular Ca2+ initiates physiological events as diverse as gene transcription, muscle contraction, cell division and exocytosis. Predictably, the metabolic machinery that elicits and responds to changes in intracellular Ca2+ is correspondingly heterogeneous. This review focuses on one element of this complex web ...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：
更新日期：1995-02-01 00:00:00
abstract：:Navigation depends upon neural systems that monitor spatial location and head orientation. Recent developmental findings have led some to conclude that these systems are innate. Such claims are premature. But also, there are more meaningful ways to arrive at answers about developmental origins than by invoking the out...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2015.01.001
更新日期：2015-02-01 00:00:00
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journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2020.10.004
更新日期：2021-02-01 00:00:00
abstract：:Glucose has long been considered the substrate for neuronal energy metabolism in the brain. Recently, an alternative explanation of energy metabolism in the active brain, the astrocyte-neuron lactate shuttle hypothesis, has received attention. It suggests that during neural activity energy needs in glia are met by ana...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/s0166-2236(00)01920-2
更新日期：2001-10-01 00:00:00
abstract：:Hodgkin and Huxley (H-H) model for action potential generation has held firm for half a century because this relatively simple and experimentally testable model embodies the major features of membrane nonlinearity: namely, voltage-dependent ionic currents that activate and inactivate in time. However, experimental and...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/s0166-2236(02)02278-6
更新日期：2002-11-01 00:00:00
