Abstract:
:Chronic pain is sustained by central neuronal sensitization, with many similar characteristics irrespective of the type of injury incurred. Nevertheless, pain arising from nerve injury (neuropathic pain) is resistant to centrally acting analgesics, whereas inflammatory pain responds well. New research indicates that the role of spinal NMDA receptors in chronic pain depends on adaptor proteins of the membrane-associated guanylate kinase (MAGUK) family and raises the possibility that complexes of different composition might contribute differentially to different pain states.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Garry EM,Fleetwood-Walker SMdoi
10.1016/j.tins.2004.03.014subject
Has Abstractpub_date
2004-06-01 00:00:00pages
292-4issue
6eissn
0166-2236issn
1878-108Xpii
S0166-2236(04)00107-9journal_volume
27pub_type
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journal_title:Trends in neurosciences
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doi:
更新日期:1995-02-01 00:00:00
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