Abstract:
:Sensory representations are repeatedly transformed by neural computations that determine which of their attributes can be effectively processed at each stage. Whereas some early computations are common across multiple sensory systems, they can utilize dissimilar underlying mechanisms depending on the properties of each modality. Recent work in the olfactory bulb has substantially clarified the neural algorithms underlying early odor processing. The high-dimensionality of odor space strictly limits the utility of topographical representations, forcing similarity-dependent computations such as decorrelation to employ unusual neural algorithms. The distinct architectures and properties of the two prominent computational layers in the olfactory bulb suggest that the bulb is directly comparable not only to the retina but also to primary visual cortex.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Cleland TAdoi
10.1016/j.tins.2009.12.004subject
Has Abstractpub_date
2010-03-01 00:00:00pages
130-9issue
3eissn
0166-2236issn
1878-108Xpii
S0166-2236(09)00203-3journal_volume
33pub_type
杂志文章,评审abstract::Serotonin (5-HT) 5-HT(3) receptors are ligand-gated ion channels, which are generally thought to be involved in the presynaptic modulation of neurotransmitter release. However, analysis of published data reveals that most of the evidence for the alleged presynaptic role of 5-HT(3) receptors in modulating CNS neurotran...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(00)01662-3
更新日期:2000-12-01 00:00:00
abstract::A variety of fatty acids regulate the activity of specific ion channels by mechanisms not involving the enzymatic pathways that convert arachidonic acid to oxygenated metabolites. Furthermore, these actions of fatty acids occur in patches of membrane excised from the cell and are not mediated by cellular signal transd...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/0166-2236(91)90069-7
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abstract::Cholinergic interneurons have emerged as one of the key players controlling network functions in the striatum. Extracellularly recorded cholinergic interneurons acquire characteristic responses to sensory stimuli during reward-related learning, including a pause and subsequent rebound in spiking. However, the precise ...
journal_title:Trends in neurosciences
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doi:10.1016/j.tins.2012.09.006
更新日期:2013-01-01 00:00:00
abstract::Dendrites of pyramidal neurons are complex, electrically active structures that can produce local and global Ca(2+) compartments. Recent studies indicate that dendrites of cortical GABAergic interneurons are also highly specialized, and that different subtypes vary in their morphology, in their intrinsic and synaptic ...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2005.01.005
更新日期:2005-03-01 00:00:00
abstract::It might appear curious to read about yeast, slime molds and protozoa in a journal dedicated to neuroscience. However, despite their distinct lack of synapses, eukaryotic microorganisms hold a wealth of information relevant to the signal-transduction pathways that underly activity in neuronal receptor cells, particula...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/0166-2236(94)90076-0
更新日期:1994-02-01 00:00:00
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(02)02261-0
更新日期:2002-12-01 00:00:00
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2014.12.001
更新日期:2015-02-01 00:00:00
abstract::Glucose has long been considered the substrate for neuronal energy metabolism in the brain. Recently, an alternative explanation of energy metabolism in the active brain, the astrocyte-neuron lactate shuttle hypothesis, has received attention. It suggests that during neural activity energy needs in glia are met by ana...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/s0166-2236(00)01920-2
更新日期:2001-10-01 00:00:00
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2015.07.005
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/0166-2236(89)90089-1
更新日期:1989-11-01 00:00:00
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/0166-2236(90)90106-k
更新日期:1990-07-01 00:00:00
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/0166-2236(95)92774-k
更新日期:1995-11-01 00:00:00
abstract::CNS myelin inhibits axonal outgrowth in vitro and is one of several obstacles to functional recovery following spinal cord injury. Central to our current understanding of myelin-mediated inhibition are the membrane protein Nogo and the Nogo-66 receptor (NgR). New findings implicate NgR as a point of convergence in sig...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
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更新日期:2003-04-01 00:00:00
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journal_title:Trends in neurosciences
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doi:10.1016/j.tins.2018.01.002
更新日期:2018-03-01 00:00:00
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/0166-2236(93)90156-g
更新日期:1993-06-01 00:00:00
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2017.01.001
更新日期:2017-03-01 00:00:00
abstract::Mechanosensation in Drosophila relies on sensory neurons transducing mechanical stimuli into ionic currents. The molecular mechanisms of this transduction are in the process of being revealed. Transduction relies on mechanogated ion channels that are activated by membrane stretch or the tension of force-conveying teth...
journal_title:Trends in neurosciences
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abstract::Speakers of different languages think about time differently in accordance with the spatial metaphors common in their languages. Furthermore, learning new spatial metaphors in language instills new non-linguistic representations of time, suggesting that language can play a causal role in constructing mental timelines....
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pub_type: 杂志文章
doi:10.1016/j.tins.2018.08.004
更新日期:2018-10-01 00:00:00
abstract::Interaural time differences (ITDs) represent an important cue in sound localization and auditory scene analysis. To assess this cue the auditory system internally delays binaural inputs to compensate for the outer delay, before neurons in the brainstem detect the coincident arrival of the inputs from the two ears. Dif...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2014.03.002
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journal_title:Trends in neurosciences
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journal_title:Trends in neurosciences
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journal_title:Trends in neurosciences
pub_type: 评论,杂志文章
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journal_title:Trends in neurosciences
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doi:10.1016/j.tins.2005.09.009
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journal_title:Trends in neurosciences
pub_type: 杂志文章
doi:10.1016/j.tins.2012.02.001
更新日期:2012-04-01 00:00:00
abstract::During the past several decades, lac permease has assumed almost tutelary proportions as a model for cotransporters. This archetypical membrane protein now exerts its influence by the most dramatic means possible: its structure is solved. This article describes the configuration and implied transport mechanism of the ...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
doi:10.1016/j.tins.2004.04.007
更新日期:2004-06-01 00:00:00
abstract::Astrocytes, which constitute the most abundant cell type in mammalian brain, are extensively coupled to one another through gap junctions composed mainly of connexin43. In regions exhibiting high levels of connexin43 expression, tens of astrocytes are labeled following single-cell intracellular injection. Importantly,...
journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
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更新日期:1996-08-01 00:00:00
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
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更新日期:1992-04-01 00:00:00
abstract::Several theories have proposed possible functions of adult neurogenesis in learning processes on a systems level, such as the avoidance of catastrophic interference and the encoding of temporal and contextual information, and in emotional behavior. Under the assumption of such functionality of new neurons, the questio...
journal_title:Trends in neurosciences
pub_type: 杂志文章
doi:10.1016/j.tins.2008.01.002
更新日期:2008-04-01 00:00:00
abstract::The fruit fly, Drosophila melanogaster, has become a model for the study of a growing number of human characteristics because of the power of its genetics. Higher cognitive functions, however, might be assumed to be out of reach for the little fly. But the cumulative history of cognitive studies in insects and some of...
journal_title:Trends in neurosciences
pub_type: 杂志文章
doi:10.1016/j.tins.2004.10.002
更新日期:2004-12-01 00:00:00
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journal_title:Trends in neurosciences
pub_type: 杂志文章,评审
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