Abstract:
:Dendrites of pyramidal neurons are complex, electrically active structures that can produce local and global Ca(2+) compartments. Recent studies indicate that dendrites of cortical GABAergic interneurons are also highly specialized, and that different subtypes vary in their morphology, in their intrinsic and synaptic conductances and in the Ca(2+) signals they generate. Because interneurons play a major role in oscillations, understanding their dendrites could offer key insights into rhythmogenesis. Different interneuron subtypes have different synaptic integration properties and generate differentially timed inhibition at distinct sites of the pyramidal neuraxis. In addition, interneuron dendrites generate diverse Ca(2+) signals that reflect this circuit function and probably also implement subclass-specific plasticity and homeostasis.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Goldberg JH,Yuste Rdoi
10.1016/j.tins.2005.01.005subject
Has Abstractpub_date
2005-03-01 00:00:00pages
158-67issue
3eissn
0166-2236issn
1878-108Xpii
S0166-2236(05)00025-1journal_volume
28pub_type
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