Abstract:
:Trans-synaptic modulation of cortical ACh efflux is a useful approach for determining the functions of cortical ACh. Bilateral modulation of basal forebrain GABAergic transmission by benzodiazepine-receptor agonists and inverse agonists decreases and increases, respectively, activated cortical ACh efflux. The determination of behavioral functions which are mediated via activated cortical ACh efflux, and therefore subject to the effects of basal forebrain GABA-cholinergic manipulations, should promote analyses of the functions of cortical ACh. Trans-synaptic approaches to enhance activated cortical ACh efflux offer some potential for the treatment of cognitive dysfunctions associated with impaired cortical cholinergic transmission.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Sarter MF,Bruno JPdoi
10.1016/0166-2236(94)90001-9subject
Has Abstractpub_date
1994-06-01 00:00:00pages
217-21issue
6eissn
0166-2236issn
1878-108Xpii
0166-2236(94)90001-9journal_volume
17pub_type
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