Abstract:
:Depression is a common cause of mortality and morbidity, but the biological bases of the deficits in emotional and cognitive processing remain incompletely understood. Current antidepressant therapies are effective in only some patients and act slowly. Here, we propose an excitatory synapse hypothesis of depression in which chronic stress and genetic susceptibility cause changes in the strength of subsets of glutamatergic synapses at multiple locations, including the prefrontal cortex (PFC), hippocampus, and nucleus accumbens (NAc), leading to a dysfunction of corticomesolimbic reward circuitry that underlies many of the symptoms of depression. This hypothesis accounts for current depression treatments and suggests an updated framework for the development of better therapeutic compounds.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Thompson SM,Kallarackal AJ,Kvarta MD,Van Dyke AM,LeGates TA,Cai Xdoi
10.1016/j.tins.2015.03.003subject
Has Abstractpub_date
2015-05-01 00:00:00pages
279-94issue
5eissn
0166-2236issn
1878-108Xpii
S0166-2236(15)00062-4journal_volume
38pub_type
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