Abstract：
:Potassium channels are crucial regulators of neuronal excitability, setting resting membrane potentials and firing thresholds, repolarizing action potentials and limiting excitability. Although most of our understanding of K+ channels is based on somatic recordings, there is good evidence that these channels are present in synaptic terminals. In recent years the improved access to presynaptic compartments afforded by direct recording techniques has indicated diverse roles for native K+ channels, from suppression of aberrant firing to action potential repolarization and activity-dependent modulation of synaptic activity. This article reviews the growing evidence for multiple roles and discrete localization of distinct K+ channels at presynaptic terminals.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Dodson PD,Forsythe IDdoi
10.1016/j.tins.2004.02.012subject
Has Abstractpub_date
2004-04-01 00:00:00pages
210-7issue
4eissn
0166-2236issn
1878-108Xpii
S0166-2236(04)00070-0journal_volume
27pub_type
杂志文章,评审abstract：:Itch is a distinct sensation arising from the superficial layers of skin and mucous membranes. It is elicited by histamine and probably other endogenous chemicals that excite subpopulations of unmyelinated primary afferents and spinal neurones projecting through the anterolateral quadrant to the brain. The two popular...
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更新日期：2004-11-01 00:00:00
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journal_title：Trends in neurosciences
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journal_title：Trends in neurosciences
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更新日期：2014-10-01 00:00:00
