Abstract：
:Recent years have seen a flourishing literature on detection of circulating autoantibodies against neurotransmitter receptors in patients with neuropsychiatric disorders. These studies have generated hope for a better understanding of the underlying molecular dysfunctions and for appropriate therapeutic strategies. However, the detection of these autoantibodies in healthy subjects, and the lack of mechanistic insights have fostered debate about the pathogenic role of such autoantibodies. Here, we specifically discuss the biological evidence linking autoantibodies directed against the glutamatergic N-methyl-d-aspartate (NMDA) receptor (NMDAR-Abs) and psychosis, emphasising recent single-molecule imaging investigations that unveiled the impaired surface trafficking of NMDAR in the presence of NMDAR-Abs from psychotic patients. Although still in its infancy, the hypothesis that NMDAR-Abs from patients with psychosis play a pathogenic role is thus gaining support, opening avenues of fundamental and translational investigations.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Jézéquel J,Johansson EM,Leboyer M,Groc Ldoi
10.1016/j.tins.2018.05.002subject
Has Abstractpub_date
2018-08-01 00:00:00pages
502-511issue
8eissn
0166-2236issn
1878-108Xpii
S0166-2236(18)30115-2journal_volume
41pub_type
杂志文章abstract：:Over the past couple of years, it has become evident that some males carrying the fragile X mental retardation (FMR1) premutation, typically viewed to be normal, in fact manifest a neurodegenerative disease with ataxia and tremor. FMR1 premutation alleles uniquely produce FMR1 transcripts with an elongated CGG repeat,...
journal_title：Trends in neurosciences
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journal_title：Trends in neurosciences
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journal_title：Trends in neurosciences
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journal_title：Trends in neurosciences
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journal_title：Trends in neurosciences
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journal_title：Trends in neurosciences
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journal_title：Trends in neurosciences
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doi：10.1016/j.tins.2007.05.001
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journal_title：Trends in neurosciences
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doi：10.1016/j.tins.2004.04.007
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journal_title：Trends in neurosciences
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journal_title：Trends in neurosciences
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journal_title：Trends in neurosciences
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journal_title：Trends in neurosciences
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abstract：:Abundant tau-positive neurofibrillary lesions constitute a defining neuropathological characteristic of Alzheimer's disease. Filamentous tau pathology is also central to a number of other dementing disorders, such as Pick's disease, progressive supranuclear palsy, corticobasal degeneration and familial frontotemporal ...
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