Abstract:
:In the mammalian central nervous system (CNS), coupling of neurons by gap junctions (i.e., electrical synapses) and the expression of the neuronal gap junction protein, connexin 36 (Cx36), transiently increase during early postnatal development. The levels of both subsequently decline and remain low in the adult, confined to specific subsets of neurons. However, following neuronal injury [such as ischemia, traumatic brain injury (TBI), and epilepsy], the coupling and expression of Cx36 rise. Here we summarize new findings on the mechanisms of regulation of Cx36-containing gap junctions in the developing and mature CNS and following injury. We also review recent studies suggesting various roles for neuronal gap junctions and in particular their role in glutamate-mediated neuronal death.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Belousov AB,Fontes JDdoi
10.1016/j.tins.2012.11.001subject
Has Abstractpub_date
2013-04-01 00:00:00pages
227-36issue
4eissn
0166-2236issn
1878-108Xpii
S0166-2236(12)00196-8journal_volume
36pub_type
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