Emerging roles of resolvins in the resolution of inflammation and pain.

abstract：:Sensory representations are repeatedly transformed by neural computations that determine which of their attributes can be effectively processed at each stage. Whereas some early computations are common across multiple sensory systems, they can utilize dissimilar underlying mechanisms depending on the properties of eac...

journal_title：Trends in neurosciences

authors： Cleland TA

更新日期：2010-03-01 00:00:00

abstract：:In mature rodents, whisker-related patterns are known to be present in three levels of the brain: the brainstem trigeminal nuclei, the ventrobasal thalamus and the somatosensory cortex. These patterns have been demonstrated using neuroanatomical tracing techniques, histological and histochemical staining methods and e...

journal_title：Trends in neurosciences

authors： Waite PM,Marotte LR,Leamey CA,Mark RF

更新日期：1998-06-01 00:00:00

abstract：:As we learn more about the functional expression of nicotinic receptors in specific brain regions such as the hippocampus, intriguing interactions are being uncovered at the cellular and circuit levels. Recent work from John Dani's laboratory provides important insights into how nicotinic receptors can modify hippocam...

journal_title：Trends in neurosciences

authors： McGehee DS

更新日期：2002-04-01 00:00:00

abstract：:Launching a new neuroscience laboratory requires knowledge of purchasing, budgeting and personnel management. The usual training of scientific investigators omits these areas, at a time when experimental complexity is growing and Internet-based commerce offers new purchasing options. This review highlights laboratory ...

journal_title：Trends in neurosciences

authors： Carmichael ST

更新日期：2002-06-01 00:00:00

abstract：:Recent opinion surveys suggest that the majority of the public is willing to accept the use of animals in research if high standards of welfare and effective regulation are in place. The public appears unaware that such standards have existed for some time. The scientific community should now re-focus its communicatio...

journal_title：Trends in neurosciences

authors： Matfield M

更新日期：2002-03-01 00:00:00

abstract：:Itch is a distinct sensation arising from the superficial layers of skin and mucous membranes. It is elicited by histamine and probably other endogenous chemicals that excite subpopulations of unmyelinated primary afferents and spinal neurones projecting through the anterolateral quadrant to the brain. The two popular...

journal_title：Trends in neurosciences

authors： McMahon SB,Koltzenburg M

更新日期：1992-12-01 00:00:00

abstract：:Recent years have seen a flourishing literature on detection of circulating autoantibodies against neurotransmitter receptors in patients with neuropsychiatric disorders. These studies have generated hope for a better understanding of the underlying molecular dysfunctions and for appropriate therapeutic strategies. Ho...

journal_title：Trends in neurosciences

authors： Jézéquel J,Johansson EM,Leboyer M,Groc L

更新日期：2018-08-01 00:00:00

abstract：:Adaptation to the ever-changing world is critical for survival, and our brains are particularly tuned to remember events that differ from previous experiences. Novel experiences induce dopamine release in the hippocampus, a process which promotes memory persistence. While axons from the ventral tegmental area (VTA) we...

journal_title：Trends in neurosciences

authors： Duszkiewicz AJ,McNamara CG,Takeuchi T,Genzel L

更新日期：2019-02-01 00:00:00

abstract：:Stress is a major trigger of seizures in people with epilepsy. Exposure to stress results in the release of several stress mediators throughout the brain, including the hippocampus, a region sensitive to stress and prone to seizures. Stress mediators interact with their respective receptors to produce distinct effects...

journal_title：Trends in neurosciences

authors： Gunn BG,Baram TZ

更新日期：2017-11-01 00:00:00

abstract：:Notions of what constitutes a neurotransmitter have changed markedly with the advent in the past decade of synaptic molecules, which satisfy key neurotransmitter criteria but differ radically from classical transmitters. Thus, NO and carbon monoxide are neither stored in synaptic vesicles nor released by exocytosis. T...

journal_title：Trends in neurosciences

authors： Barañano DE,Ferris CD,Snyder SH

更新日期：2001-02-01 00:00:00

abstract：:Since early anatomical descriptions, the existence of dendritic spines has stimulated intense curiosity and speculation about their regulation and function. Research over the past three decades has described an impressive mutability in dendritic-spine number and morphology under a variety of physiological circumstance...

journal_title：Trends in neurosciences

authors： Halpain S

更新日期：2000-04-01 00:00:00

abstract：:Intracellular Ca2+ initiates physiological events as diverse as gene transcription, muscle contraction, cell division and exocytosis. Predictably, the metabolic machinery that elicits and responds to changes in intracellular Ca2+ is correspondingly heterogeneous. This review focuses on one element of this complex web ...

journal_title：Trends in neurosciences

authors： Dunlap K,Luebke JI,Turner TJ

更新日期：1995-02-01 00:00:00

abstract：:Huntington's disease (HD) is a fatal, inherited neurodegenerative disorder that gradually robs affected individuals of memory, cognitive skills and normal movements. Although research has identified a single faulty gene, the huntingtin gene, as the cause of the disease, a cure remains elusive. Strong evidence indicate...

journal_title：Trends in neurosciences

authors： Bossy-Wetzel E,Petrilli A,Knott AB

更新日期：2008-12-01 00:00:00

abstract：:It has become apparent in recent years that the cytoskeleton and its associated proteins play a major role in secretion. This review summarizes recent findings on the cytoskeleton organization and the molecular topology of its regulatory proteins, as well as the dynamic changes that occur in this organelle during secr...

journal_title：Trends in neurosciences

authors： Trifaró JM,Vitale ML

更新日期：1993-11-01 00:00:00

abstract：:GABA neurotransmission requires a specialized set of proteins to synthesize, transport or respond to GABA. This article reviews results from a genetic strategy in the nematode Caenorhabditis elegans designed to identify the genes responsible for these activities. These studies identified mutations in genes encoding fi...

journal_title：Trends in neurosciences

authors： Schuske K,Beg AA,Jorgensen EM

更新日期：2004-07-01 00:00:00

abstract：:Complement proteins are ancient components of innate immunity that have emerged as crucial regulators of neural networks. We discuss these roles in the context of the CNS development, acute CNS viral infections, and post-infectious and noninfectious CNS disorders, with an emphasis on microglia-mediated loss of synapse...

journal_title：Trends in neurosciences

authors： Kanmogne M,Klein RS

更新日期：2021-02-01 00:00:00

abstract：:Glucose has long been considered the substrate for neuronal energy metabolism in the brain. Recently, an alternative explanation of energy metabolism in the active brain, the astrocyte-neuron lactate shuttle hypothesis, has received attention. It suggests that during neural activity energy needs in glia are met by ana...

journal_title：Trends in neurosciences

authors： Chih CP,Lipton P,Roberts EL Jr

更新日期：2001-10-01 00:00:00

abstract：:Mis-sense mutations of presenilin 1 increase the release of amyloidogenic peptide from amyloid precursor protein (APP) and are a major cause of familial Alzheimer's Disease. Loss-of-function mutations of presenilins in the mouse, Caenorhabditis elegans and Drosophila result in severe developmental defects caused by di...

journal_title：Trends in neurosciences

authors： Annaert W,De Strooper B

更新日期：1999-10-01 00:00:00

abstract：:Voltage-dependent Ca2+ channels are one of the main routes for the entry of Ca2+ into excitable cells. These channels are unique in cell-signalling terms in that they can transduce an electrical signal (membrane depolarization) via Ca2+ entry into a chemical signal, by virtue of the diverse range of intracellular Ca(2...

journal_title：Trends in neurosciences

authors： Dolphin AC

更新日期：1996-01-01 00:00:00

abstract：:The ability of central synapses to undergo long-term potentiation (LTP) still captures the imagination of scientists and has become one of the most fascinating and deeply studied questions in modern neuroscience. By the mid-1990s, however, the field was deeply ensnarled in trying to answer a passionately dichotomous q...

journal_title：Trends in neurosciences

authors： Vincent-Lamarre P,Lynn M,Béïque JC

更新日期：2018-09-01 00:00:00

abstract：:The transition from short- to long-term memory requires lasting modulations of synaptic connectivity. In a variety of species and learning tasks, enhanced synthesis of glycoprotein cell-adhesion molecules (CAMs), such as neural CAM (NCAM) and Ll, 5-8 h post-training is a necessary step in this process. If the training...

journal_title：Trends in neurosciences

authors： Rose SP

更新日期：1995-11-01 00:00:00

abstract：:The fruit fly, Drosophila melanogaster, has become a model for the study of a growing number of human characteristics because of the power of its genetics. Higher cognitive functions, however, might be assumed to be out of reach for the little fly. But the cumulative history of cognitive studies in insects and some of...

journal_title：Trends in neurosciences

authors： Greenspan RJ,van Swinderen B

更新日期：2004-12-01 00:00:00

abstract：:Behavioral evidence from phylogenetically diverse animals and from humans suggests that, by extracting temporal information inherent in the olfactory signal, olfaction is more involved in interpreting space and time than heretofore imagined. If this is the case, the olfactory system must have neural mechanisms capable...

journal_title：Trends in neurosciences

authors： Ache BW,Hein AM,Bobkov YV,Principe JC

更新日期：2016-10-01 00:00:00

abstract：:Rhythmical brain activity around 5Hz can be observed in the prefrontal cortex under conditions requiring high levels of cognitive control. However, its temporal dynamics are still elusive. A recent research paper (Cooper et al. Neuroimage 2019;189:130-140) provides evidence that the temporal evolution of this frontal-...

journal_title：Trends in neurosciences

authors： Sauseng P,Tschentscher N,Biel AL

更新日期：2019-05-01 00:00:00

abstract：:Nearly 30 years ago, a debate over two disparate models of synaptic vesicle retrieval arose. Subsequent investigations to determine which model was correct proved inconclusive and served only to further the debate. However, recent evidence has begun to suggest that both models are valid and relevant in understanding t...

journal_title：Trends in neurosciences

authors： Wilkinson RS,Cole JC

更新日期：2001-04-01 00:00:00

abstract：:Parkinson's disease is a common and disabling disorder of movement owing to dopaminergic denervation of the striatum. However, it is still unclear how this denervation perverts normal functioning to cause slowing of voluntary movements. Recent work using tissue slice preparations, animal models and in humans with Park...

journal_title：Trends in neurosciences

authors： Hammond C,Bergman H,Brown P

更新日期：2007-07-01 00:00:00

abstract：:It might appear curious to read about yeast, slime molds and protozoa in a journal dedicated to neuroscience. However, despite their distinct lack of synapses, eukaryotic microorganisms hold a wealth of information relevant to the signal-transduction pathways that underly activity in neuronal receptor cells, particula...

journal_title：Trends in neurosciences

authors： Van Houten J

更新日期：1994-02-01 00:00:00

abstract：:Recognition of foreign or misplaced nucleic acids is one of the principal modes by which the immune system detects pathogenic entities. When cytosolic DNA is sensed, a signal is relayed via the cGAS-STING pathway: this involves the activation of cyclic GMP-AMP (cGMP-AMP) synthase (cGAS) and generation of the cyclic di...

journal_title：Trends in neurosciences

authors： Paul BD,Snyder SH,Bohr VA

更新日期：2021-02-01 00:00:00

abstract：:The complexity and inaccessibility of the vertebrate CNS impede the localization and description of memory traces and the definition of the processes that create them. Recent work has shown that the spinal stretch reflex (SSR), which is produced by a monosynaptic two-neuron pathway, can be operantly conditioned, and t...

journal_title：Trends in neurosciences

authors： Wolpaw JR,Carp JS

更新日期：1990-04-01 00:00:00

abstract：:For organs innervated by the autonomic nervous system, it is generally held that neuroeffector transmission is achieved by varicosities releasing transmitters some distance from the membranes of target cells. Transmitters are thought to diffuse through the extracellular space and interact with post-junctional receptor...

journal_title：Trends in neurosciences

authors： Hirst GD,Bramich NJ,Edwards FR,Klemm M

更新日期：1992-02-01 00:00:00