Abstract:
:The nigrostriatal dopamine (DA) system has an essential role in the selection and control of movement sequences, and its degeneration causes the characteristic motor symptoms of Parkinson's disease. Parkinsonian motor symptoms are alleviated by L-DOPA, but this treatment induces motor fluctuations and dyskinesias (abnormal involuntary movements). Clinical and experimental findings indicate that the motor complications of L-DOPA pharmacotherapy are triggered by transient and large changes in extracellular DA levels. The disruption of presynaptic DA homeostasis sets in motion a cascade of postsynaptic alterations, which prime the brain for a complicated motor response to dopaminomimetic treatment. L-DOPA-induced dyskinesia provides a paradigm to study how the dysregulation of DA release and clearance results in maladaptive neuroplasticity sustaining abnormal patterns of movement.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Cenci MAdoi
10.1016/j.tins.2007.03.005subject
Has Abstractpub_date
2007-05-01 00:00:00pages
236-43issue
5eissn
0166-2236issn
1878-108Xpii
S0166-2236(07)00066-5journal_volume
30pub_type
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